Why salad helps you say yes to 'NO'

March 23, 2011, Journal of Clinical Investigation

Disorders of the circulatory system- vascular diseases- are common in the developed world, and can lead to heart attacks, strokes and even death. However, treatments for these disorders, such as bypass surgery and angioplasty, themselves induce vascular injury, after which the cells of the blood vessel can over-proliferate in a way that limits blood flow.

Nitric oxide (NO) is an important molecule that helps maintain the contractility and health of vascular , and multiple studies have linked vascular pathology to a decreased level of NO. Therefore, therapies that increase the availability of NO could help protect vascular health.

NO is synthesized from arginine by an enzyme called synthase (NOS). In new research, Brian Zuckerbraun and colleagues, of the University of Pittsburgh, in Pittsburgh, Pennsylvania, determined that after vessel injury in the rat, the NOS pathway is disrupted, but a secondary pathway that generates NO from nitrate is activated. Furthermore, supplementing rats with nitrate before inducing vessel injury markedly limited the extent of the damage, while a diet low in nitrate exacerbated it.

In the accompanying commentary, John Cooke and Yohannes Ghebremariam of Stanford University in Stanford, California point out that high levels of dietary nitrate might in part explain the vascular benefits of diets rich in leafy greens, but warn that high dose supplementation could lead to the generation of carcinogenic molecules.

More information: Nitrite-generated NO circumvents dysregulated arginine/NOS signaling to protect against intimal hyperplasia in Sprague-Dawley rats
View this article at: www.jci.org/articles/view/4407 … 1e749dd41ac25c7e8efd

Dietary nitrate, nitric oxide, and restenosis
View this article at: www.jci.org/articles/view/5719 … 08699995280948c7eabd

Related Stories

Recommended for you

Researchers illustrate how muscle growth inhibitor is activated, could aid in treating ALS

January 19, 2018
Researchers at the University of Cincinnati (UC) College of Medicine are part of an international team that has identified how the inactive or latent form of GDF8, a signaling protein also known as myostatin responsible for ...

Bioengineered soft microfibers improve T-cell production

January 18, 2018
T cells play a key role in the body's immune response against pathogens. As a new class of therapeutic approaches, T cells are being harnessed to fight cancer, promising more precise, longer-lasting mitigation than traditional, ...

Weight flux alters molecular profile, study finds

January 17, 2018
The human body undergoes dramatic changes during even short periods of weight gain and loss, according to a study led by researchers at the Stanford University School of Medicine.

Secrets of longevity protein revealed in new study

January 17, 2018
Named after the Greek goddess who spun the thread of life, Klotho proteins play an important role in the regulation of longevity and metabolism. In a recent Yale-led study, researchers revealed the three-dimensional structure ...

The HLF gene protects blood stem cells by maintaining them in a resting state

January 17, 2018
The HLF gene is necessary for maintaining blood stem cells in a resting state, which is crucial for ensuring normal blood production. This has been shown by a new research study from Lund University in Sweden published in ...

Magnetically applied MicroRNAs could one day help relieve constipation

January 17, 2018
Constipation is an underestimated and debilitating medical issue related to the opioid epidemic. As a growing concern, researchers look to new tools to help patients with this side effect of opioid use and aging.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.