New Lyme disease test improves treatment for horses, dogs

June 17, 2011 By Carly Hodes, Cornell University

Romping through summer fields seems like a harmless pleasure for dogs, horses and humans alike. But just one bite from the wrong tick can rob an animal of that pastime. The bacteria Borrelia burgdorferi catch rides with certain species of ticks and can cause Lyme disease in animals the ticks bite. Catching the disease early is paramount because it becomes progressively harder to fight as the bacteria conduct guerilla warfare from hiding places in the joints, nervous tissues and organs of their hosts.

A for in horses and dogs, developed by researchers at the Animal Health Diagnostic Center (AHDC) at the College of Veterinary Medicine at Cornell, will improve our understanding of the disease and pinpoint time of infection, opening possibilities for earlier intervention and more effective treatment plans.

"We've offered Lyme disease testing for years," said Bettina Wagner, the Harry M. Zweig Associate Professor in Equine Health and lead developer of the test, "but we have recently been able to improve our techniques with the multiplex testing procedure. The new test exceeds its predecessors in accuracy, specificity and analytical sensitivity."

The multiplex procedure, which can detect three different produced in response to the bacteria associated with Lyme disease using a single test on the sample, eliminates the need for separate tests. In addition, it requires smaller samples and answers more questions about the disease. Multiplex technology has been used for the last decade, but the AHDC is the first veterinary diagnostic laboratory to use it to test for Lyme disease.

Different kinds of antibodies can be found in the body at different stages of infection. The new test can distinguish and measure these differences, giving more information about the timing of the disease.

The bacteria that cause Lyme disease are particularly difficult to detect, according to Wagner, because after infection they tend to hide where they can't be found. They bury in the joints of dogs, causing arthritis or lameness. Serious kidney disease has also been associated with Lyme infections in dogs. In humans and horses, they also burrow into the nervous system, in the spine or the brain, causing pain, paralysis or behavioral changes. By the time such clinical signs appear, the bacteria are usually not in circulation anymore.

"Now we can distinguish between infection and vaccination and also between early and chronic infection stages," Wagner said. "That was not possible before. You were able to say whether an animal was infected, but not when it was infected, or how far the had developed."

The test and information the provides can help veterinarians make advanced decisions about treatment. After the long treatment period ends, veterinarians usually conduct follow-up testing to see if it was successful.

Explore further: Lyme disease bacteria take cover in lymph nodes

Related Stories

Lyme disease bacteria take cover in lymph nodes

June 16, 2011
The bacteria that cause Lyme disease, one of the most important emerging diseases in the United States, appear to hide out in the lymph nodes, triggering a significant immune response, but one that is not strong enough to ...

Lyme disease bacteria take cover in lymph nodes, study finds

June 9, 2011
(Medical Xpress) -- The bacteria that cause Lyme disease, one of the most important emerging diseases in the United States, appear to hide out in the lymph nodes, triggering a significant immune response, but one that is ...

Deer tick bacteria DNA in joint fluid not reliable marker of active lyme arthritis

May 17, 2011
New research shows that polymerase chain reaction (PCR) testing for Borrelia burgdorferi DNA—the spirochetal bacteria transmitted by deer ticks—in joint fluid may confirm the diagnosis of Lyme arthritis, but is ...

Recommended for you

Creation of synthetic horsepox virus could lead to more effective smallpox vaccine

January 19, 2018
UAlberta researchers created a new synthetic virus that could lead to the development of a more effective vaccine against smallpox. The discovery demonstrates how techniques based on the use of synthetic DNA can be used to ...

Study ends debate over role of steroids in treating septic shock

January 19, 2018
The results from the largest ever study of septic shock could improve treatment for critically ill patients and save health systems worldwide hundreds of millions of dollars each year.

New approach could help curtail hospitalizations due to influenza infection

January 18, 2018
More than 700,000 Americans were hospitalized due to illnesses associated with the seasonal flu during the 2014-15 flu season, according to federal estimates. A radical new approach to vaccine development at UCLA may help ...

Zika virus damages placenta, which may explain malformed babies

January 18, 2018
Though the Zika virus is widely known for a recent outbreak that caused children to be born with microencephaly, or having a small head, and other malformations, scientists have struggled to explain how the virus affects ...

Certain flu virus mutations may compensate for fitness costs of other mutations

January 18, 2018
Seasonal flu viruses continually undergo mutations that help them evade the human immune system, but some of these mutations can reduce a virus's potency. According to new research published in PLOS Pathogens, certain mutations ...

Study reveals how MRSA infection compromises lymphatic function

January 17, 2018
Infections of the skin or other soft tissues with the hard-to-treat MRSA (methicillin-resistant Staphylococcus aureus) bacteria appear to permanently compromise the lymphatic system, which is crucial to immune system function. ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.