High-dose vitamin D may not be better than low-dose vitamin D in treating MS

Low vitamin D levels are associated with an increased risk of developing multiple sclerosis (MS), but the first randomized, controlled trial using high-dose vitamin D in MS did not find any added benefit over and above ongoing low-dose vitamin D supplementation, according to a study published in the October 25, 2011, issue of Neurology, the medical journal of the American Academy of Neurology.

"We did not find added benefit from high-dose vitamin D over and above ongoing low-dose vitamin D supplementation, but these results need to be confirmed with larger studies," said Mark S. Stein, MBBS, PhD, FRACP, of The Royal Melbourne Hospital and The Walter and Eliza Hall Institute of Medical Research in Parkville, Australia.

The six-month study involved 23 people with the relapsing-remitting form of MS. All of the participants received low-dose vitamin D (1,000 international units daily) to prevent any . Half of the participants also received high-dose to elevate their blood vitamin D to high levels (with a target serum 25-hydroxyvitamin D level of 130-175nM). The other half received a placebo high-dose.

of the participants' brains were performed at the start of the study and again after four, five and six months. There was no significant difference between the two groups in the number of new abnormalities that had formed in the brain after six months and no significant difference in the change in the total volume of .

Four of the 11 people taking the high-dose vitamin D, or 37 percent, had a where their MS symptoms worsened during the study, while none of the 12 people taking only low-dose vitamin D had any relapses.

Stein noted that the study involved people who had MS for an average of six years. "It's possible that studies of high-dose vitamin D at an earlier stage of MS may lead to different results," he said.


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Oct 30, 2011
Ergocalciferol is the plant form of vitamin d The human form is cholecalciferol. The differences are set out in the papers "The case against ergocalciferol (vitamin D2) as a vitamin supplemen" and "Vitamin D2 Is Much Less Effective than Vitamin D3 in Humans" Using ergocalciferol speeds up the rate the body disposes of the vitamin so can be counterproductive.
We must also understand that even when using D3 that it takes TIME to correct a lifetimes deficiency status. While 10,000iu daily for 3 months typically will restore circulating levels Doctors who have maintained patients on higher levels for longer find it may take 3 years before circulating levels begin to rise above 60ng/ml indicating the Vitamin D stores are full. See Dr Davis "Topping up your Vitamin d Tank" a study lasting 6months cannot have given sufficient time for the impact of Vitamin d on MMP levels to have had any effect.

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