Diet soda linked to increase in glucagon-like peptide 1 levels

Diet soda linked to increase in glucagon-like peptide 1 levels
Drinking a diet soda before a glucose load is associated with increased glucagon-like peptide 1 secretion in individuals with type 1 diabetes and healthy controls, but not in those with type 2 diabetes, according to research published online March 12 in Diabetes Care.

(HealthDay) -- Drinking a diet soda before a glucose load is associated with increased glucagon-like peptide 1 (GLP-1) secretion in individuals with type 1 diabetes and healthy controls, but not in those with type 2 diabetes, according to research published online March 12 in Diabetes Care.

Rebecca J. Brown, M.D., M.H.S.C., of the National Institute of Diabetes and Digestive and Kidney Diseases in Bethesda, Md., and colleagues conducted a randomized, crossover study involving nine individuals with type 1 diabetes, 10 with type 2 diabetes, and 25 healthy controls, aged 12 to 25 years. Participants drank either a cola-flavored, caffeine-free or carbonated water, followed by a 75-gram glucose load. They then underwent glucose, C-peptide, GLP-1, glucose-dependent insulinotropic peptide, and peptide Tyr-Tyr measurements for 180 minutes.

Compared with carbonated water, the researchers found that, after ingestion of diet soda, the GLP-1 area under the curve was 34 percent higher in healthy subjects and 43 percent higher in individuals with (P = 0.029 and 0.020, respectively), but was unaffected in subjects with type 2 diabetes. None of the other gut hormone measures were significantly statistically different between the groups after ingestion of diet soda or carbonated water.

"It is unknown whether changes in endogenous GLP-1 secretion as observed in the current study have any clinically relevant consequences, such as increased satiety and slowed gastric emptying," the authors write.


Explore further

Research reveals hormone action that could lead to treatments for type 2 diabetes

More information: Abstract
Full Text (subscription or payment may be required)

Copyright © 2012 HealthDay. All rights reserved.

Citation: Diet soda linked to increase in glucagon-like peptide 1 levels (2012, March 22) retrieved 23 October 2019 from https://medicalxpress.com/news/2012-03-diet-soda-linked-glucagon-like-peptide.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
 shares

Feedback to editors

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more