Staph sepsis increases mortality in preterm infants

March 12, 2012
Staph sepsis increases mortality in preterm infants

(HealthDay) -- Only about 1 percent of very low birth weight (VLBW) infants develop methicillin-resistant Staphylococcus aureus (MRSA) infections, and the morbidity and mortality are similar to that seen in infants with methicillin-susceptible S. aureus (MSSA) infections, according to a study published online March 12 in Pediatrics.

Andi L. Shane, M.D., M.P.H., from the Emory University School of Medicine in Atlanta, and colleagues analyzed data on morbidity and mortality for 8,444 VLBW infants (birth weight, 401 to 1,500 g), of whom 316 (3.7 percent) had S. aureus bacteremia and/or meningitis.

The researchers found that 88 of the 316 cases (28 percent) were MRSA and 228 cases (72 percent) were MSSA, with no overlap. The two groups were similar in terms of morbidities such as the need for , diagnosis of , and necrotizing enterocolitis. Nearly all (99 percent) of occurred >72 hours after birth. Mortality was high but similar in the resistant and susceptible groups (26 versus 24 percent).

"Few VLBW infants had S. aureus bacteremia and/or meningitis. The 1 percent with MRSA had morbidity and mortality rates similar to infants with MSSA," Shane and colleagues conclude. "Practices should provide equal focus on prevention and management of both MRSA and MSSA infections among VLBW infants."

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Recommended for you

Creation of synthetic horsepox virus could lead to more effective smallpox vaccine

January 19, 2018
UAlberta researchers created a new synthetic virus that could lead to the development of a more effective vaccine against smallpox. The discovery demonstrates how techniques based on the use of synthetic DNA can be used to ...

Study ends debate over role of steroids in treating septic shock

January 19, 2018
The results from the largest ever study of septic shock could improve treatment for critically ill patients and save health systems worldwide hundreds of millions of dollars each year.

Flu may be spread just by breathing, new study shows; coughing and sneezing not required

January 18, 2018
It is easier to spread the influenza virus (flu) than previously thought, according to a new University of Maryland-led study released today. People commonly believe that they can catch the flu by exposure to droplets from ...

New approach could help curtail hospitalizations due to influenza infection

January 18, 2018
More than 700,000 Americans were hospitalized due to illnesses associated with the seasonal flu during the 2014-15 flu season, according to federal estimates. A radical new approach to vaccine development at UCLA may help ...

Zika virus damages placenta, which may explain malformed babies

January 18, 2018
Though the Zika virus is widely known for a recent outbreak that caused children to be born with microencephaly, or having a small head, and other malformations, scientists have struggled to explain how the virus affects ...

Certain flu virus mutations may compensate for fitness costs of other mutations

January 18, 2018
Seasonal flu viruses continually undergo mutations that help them evade the human immune system, but some of these mutations can reduce a virus's potency. According to new research published in PLOS Pathogens, certain mutations ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.