New estimates up dementia rates in mid-income countries

May 24, 2012
New estimates up dementia rates in mid-Income countries
Use of 10/66 dementia diagnosis criteria results in an increase in the estimated incidence of dementia in middle-income countries, according to a study published online May 23 in The Lancet.

(HealthDay) -- Use of 10/66 dementia diagnosis criteria (10/66) results in an increase in the estimated incidence of dementia in middle-income countries, according to a study published online May 23 in The Lancet.

To investigate the incidence of dementia, Martin Prince, M.D., from King's College London, and colleagues conducted a population-based cohort study of 12,887 individuals aged 65 years or older residing in urban sites in Cuba, the Dominican Republic, and Venezuela, and in rural and urban sites in Peru, Mexico, and China. Three to five years after cohort inception, incident dementia was ascertained using 10/66 and , Fourth Edition (DSM-IV) criteria.

Of the participants interviewed at baseline, the researchers found that 11,718 were free of dementia, 69 percent of whom were reinterviewed. During the resulting 34,718 person-years of follow-up, the incidence for 10/66 dementia was 1.4 to 2.7 times higher than the incidence for DSM-IV dementia, ranging from 18.2 to 30.4 per 1,000 person-years. Compared with those who were dementia-free, the risk of mortality was 1.56 to 5.69 times higher for individuals with dementia at baseline. Based on 10/66 , increased incidence of dementia correlated with increased age (hazard ratio [HR], 1.67), and decreased incidence of dementia correlated with male sex (HR, 0.72) and higher education (HR, 0.89); no significant correlation was observed with occupational attainment (HR, 1.04; 95 percent confidence interval, 0.95 to 1.13).

"Our results provide supportive evidence for the cognitive reserve hypothesis, showing that in middle-income countries as in high-income countries, education, literacy, , and motor sequencing confer substantial protection against the onset of dementia," the authors write.

The 10/66 Research Group works closely with Alzheimer's Disease International, which is partially funded by the pharmaceutical industry.

Explore further: Mild cognitive impairment is associated with disability and neuropsychiatric symptoms

More information: Abstract
Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Related Stories

Mild cognitive impairment is associated with disability and neuropsychiatric symptoms

February 7, 2012
In low- and middle-income countries, mild cognitive impairment—an intermediate state between normal signs of cognitive aging, such as becoming increasingly forgetful, and dementia, which may or may not progress—is ...

Keeping up your overall health may keep dementia away

July 13, 2011
Improving and maintaining health factors not traditionally associated with dementia, such as denture fit, vision and hearing, may lower a person's risk for developing dementia, according to a new study published in the July ...

Demographic, clinical factors appear associated with survival in patients with Parkinson's disease

January 2, 2012
Demographics and clinical factors appear to be associated with survival in patients with Parkinson disease (PD), and the presence of dementia is associated with a significant increase in mortality, according to a report in ...

Recommended for you

Alzheimer's Tau protein forms toxic complexes with cell membranes

November 22, 2017
The brains of patients with Alzheimer's disease contain characteristic tangles inside neurons. These tangles are formed when a protein called Tau aggregates into twisted fibrils. As a result, the neurons' transport systems ...

Researchers reveal new details on aged brain, Alzheimer's and dementia

November 21, 2017
In a comprehensive analysis of samples from 107 aged human brains, researchers at the Allen Institute for Brain Science, UW Medicine and Kaiser Permanente Washington Health Research Institute have discovered details that ...

Dementia study sheds light on how damage spreads through brain

November 20, 2017
Insights into how a key chemical disrupts brain cells in a common type of dementia have been revealed by scientists.

Study shows video games could cut dementia risk in seniors

November 16, 2017
Could playing video games help keep the brain agile as we age?

New player in Alzheimer's disease pathogenesis identified

November 14, 2017
Scientists at Sanford Burnham Prebys Medical Discovery Institute (SBP) have shown that a protein called membralin is critical for keeping Alzheimer's disease pathology in check. The study, published in Nature Communications, ...

Biomarker may predict early Alzheimer's disease

November 10, 2017
Researchers at Sanford Burnham Prebys Medical Discovery Institute (SBP) have identified a peptide that could lead to the early detection of Alzheimer's disease (AD). The discovery, published in Nature Communications, may ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.