Anti-HTN drugs have distinct effect on central, brachial SBP

June 6, 2012
Anti-HTN drugs have distinct effect on central, brachial SBP
A reduction in central to brachial amplification induced by some antihypertensive drugs may result in lesser reductions in central than brachial systolic blood pressure, according to research published online May 25 in the British Journal of Clinical Pharmacology.

(HealthDay) -- A reduction in central to brachial amplification induced by some antihypertensive drugs may result in lesser reductions in central than brachial systolic blood pressure, according to research published online May 25 in the British Journal of Clinical Pharmacology.

Charlotte H. Manisty, M.D., and Alun D. Hughes, M.D., of the Imperial College London, conducted a systematic review and meta-analysis of 24 randomized, controlled trials to compare the effects of different classes of antihypertensive medications on brachial and central (bSBP and cSBP) and augmentation index.

In studies comparing an antihypertensive drug with placebo, the researchers found that antihypertensive therapy reduced bSBP to a greater extent than cSBP, with no between-drug class differences. In trials comparing two different antihypertensive medications, thiazide diuretics, beta-blockers and beta-blocker-containing combinations, and omapatrilat treatment resulted in decreased central to brachial amplification, but other monotherapies lowered cSBP and bSBP to a similar extent. Augmentation index was increased with beta-blocker treatment and reduced by other antihypertensive agents.

"Beta-blockers, diuretics, and combinations containing beta-blockers tend to reduce central to brachial amplification, which implies that achievement of target bSBP may be associated with lesser reductions in cSBP with these classes of agent," the authors write. "This could contribute to differences in outcomes in randomized clinical trials comparing beta-blocker- and/or diuretic-based antihypertensive therapy with other regimens."

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Recommended for you

A sodium surprise: Engineers find unexpected result during cardiac research

July 20, 2017
Irregular heartbeat—or arrhythmia—can have sudden and often fatal consequences. A biomedical engineering team at Washington University in St. Louis examining molecular behavior in cardiac tissue recently made a surprising ...

Want to win at sports? Take a cue from these mighty mice

July 20, 2017
As student athletes hit training fields this summer to gain the competitive edge, a new study shows how the experiences of a tiny mouse can put them on the path to winning.

'Smart' robot technology could give stroke rehab a boost

July 19, 2017
Scientists say they have developed a "smart" robotic harness that might make it easier for people to learn to walk again after a stroke or spinal cord injury.

Engineered liver tissue expands after transplant

July 19, 2017
Many diseases, including cirrhosis and hepatitis, can lead to liver failure. More than 17,000 Americans suffering from these diseases are now waiting for liver transplants, but significantly fewer livers are available.

Lunatic Fringe gene plays key role in the renewable brain

July 19, 2017
The discovery that the brain can generate new cells - about 700 new neurons each day - has triggered investigations to uncover how this process is regulated. Researchers at Baylor College of Medicine and Jan and Dan Duncan ...

New animal models for hepatitis C could pave the way for a vaccine

July 19, 2017
They say that an ounce of prevention is worth a pound of cure. In the case of hepatitis C—a disease that affects nearly 71 million people worldwide, causing cirrhosis and liver cancer if left untreated—it might be worth ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.