Aspirin may not prevent blood clots that cause heart attacks and strokes among diabetics

June 25, 2012

Many patients with type 2 diabetes may be aspirin resistant. That means the standard aspirin dose may not protect them against blood clots that cause heart attacks and strokes among diabetics, a new clinical study finds. The results to be presented at The Endocrine Society's 94th Annual Meeting in Houston.

"This result adds to our understanding of the prevalence of this problem, which varies considerably among studies," said lead author Subhashini Yaturu, M.D., section chief of the Department at Stratton VA Medical Center in Albany, NY. "The standard baby aspirin may not be adequate for subjects with diabetes for cardiovascular protection."

Low doses of aspirin are recommended for the prevention of strokes and heart attacks. Aspirin is considered the usual treatment to prevent dangerous blood clots from forming. It is recommended for patients with diabetes and other high-risk medical conditions. In some cases, however, patients are resistant to aspirin's anti-clotting effects. This resistance can be identified by measuring the level of a particular chemical called 11-dehydro-thromboxane beta-2, or 11DhTx2, which is formed during the clotting process. High urinary levels of this chemical indicate resistance to aspirin and its beneficial anti-clotting effects.

The most common form of diabetes, type 2, affects nearly 11 million people age 65 and older in the United States, according to the National Diabetes Information Clearinghouse. The leading causes of death among people with this disease are and stroke.

In this clinical study, investigators found that more than half—53 percent—of study participants with type 2 diabetes were aspirin resistant. In addition, 11DhTx2 levels were greater among patients with a longer duration of diabetes and increased urinary levels of a particular protein, called micro albumin, an indicator of early kidney disease in diabetes. At the same time, 11DhTx2 concentrations were not associated with insulin levels, insulin resistance, or certain markers of inflammation.

High blood pressure and abdominal-fat distribution are associated with the risk of heart and blood-vessel disease. A surprising finding, according to Yaturu, was that patients with relatively higher blood-pressure readings and a greater waist circumference had lower 11DhTx2 measurements, compared to other patients.

"These results provide new information about the factors associated with aspirin resistance," Yaturu said. "This may help doctors identify people who are likely to be aspirin resistant, so that higher doses or different drugs can be prescribed to prevent . Further studies are required to clarify the appropriate dose of aspirin and or other therapies for subjects with diabetes to prevent clots. "

Participants included 142 male patients with . Their average age was 48 years, and most were Caucasian. The samples for this clinical study were collected at Overton Brooks VAMC, Shreveport, LA between 2006 and 2009 and funded by a VA Merit Review grant for a separate study entitled, "Effect of Pioglitazone on Bone density and bone markers." For the study of resistance, supplemental analyses of the samples were carried out at Stratton VAMC and Research Pharmacy Institute at Albany. The residual funds from the Merit Review grant partly supported the study.

Explore further: Aspirin enhances platelet isoprostanes in type 2 diabetes

Related Stories

Aspirin enhances platelet isoprostanes in type 2 diabetes

March 23, 2012
(HealthDay) -- For patients with type 2 diabetes mellitus (T2DM) who are treated with aspirin, isoprostanes are overproduced, which is linked with enhanced platelet recruitment, according to a study published online March ...

Higher daily dose of aspirin could play key role in preventing heart attacks for those with diabetes

July 5, 2011
In some cases, an apple a day may keep the doctor away, but for people with diabetes, regular, over-the-counter Aspirin may also do the job.

Recommended for you

Personalized blood sugar goals can save diabetes patients thousands

December 11, 2017
A cost analysis by researchers at the University of Chicago Medicine shows treatment plans that set individualized blood sugar goals for diabetes patients, tailored to their age and health history, can save $13,546 in health ...

Kidney disease increases risk of diabetes, study shows

December 11, 2017
Diabetes is known to increase a person's risk of kidney disease. Now, a new study from Washington University School of Medicine in St. Louis suggests that the converse also is true: Kidney dysfunction increases the risk of ...

Type 2 diabetes is not for life

December 5, 2017
Almost half of the patients with Type 2 diabetes supported by their GPs on a weight loss programme were able to reverse their diabetes in a year, a study has found.

Skipping breakfast disrupts 'clock genes' that regulate body weight

November 30, 2017
Irregular eating habits such as skipping breakfast are often associated with obesity, type 2 diabetes, hypertension and cardiovascular disease, but the precise impact of meal times on the body's internal clock has been less ...

Type 2 diabetes has hepatic origins

November 28, 2017
Affecting as many as 650 million people worldwide, obesity has become one of the most serious global health issues. Among its detrimental effects, it increases the risk of developing metabolic conditions, and primarily type ...

Critical link between obesity and diabetes has been identified

November 28, 2017
UT Southwestern researchers have identified a major mechanism by which obesity causes type 2 diabetes, which is a common complication of being overweight that afflicts more than 30 million Americans and over 400 million ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.