Factors ID'd in healing failure of diabetic foot ulcers

June 15, 2012

(HealthDay) -- Patients with diabetes whose foot ulcers fail to heal have increased inflammation and aberrant growth factor levels, according to a study published online June 11 in Diabetes.

Thanh Dinh, D.P.M., from the Beth Israel Deaconess Medical Center in Boston, and colleagues followed 104 patients with type 1 or 2 diabetes and 36 healthy controls to investigate whether vascular function and inflammation play a role in the development and healing of .

The researchers found that, after a mean of 18.4 months, 30 patients with diabetes (29 percent) developed foot ulcers. These patients had more severe neuropathy, a higher white , and reduced vasodilation. Ulcers failed to heal in 47 percent of these patients. Compared with those who healed, these patients had higher serum levels of tumor necrosis factor-alpha, monocyte chemoattractant protein-1, matrix metallopeptidase 9 (MMP-9), and fibroblast growth factor 2. Compared with skin samples from control patients, patients with diabetes had greater immune cell infiltration, MMP-9 expression, and protein tyrosine phosphatase-1B (PTP1B).

"We conclude that increased inflammation, expression of MMP-9, PTP1B, and aberrant growth factor levels are the main factors associated with failure to heal diabetic foot ulcers," Dinh and colleagues write.

Explore further: Gene profile correlates with glycemia in type 1 diabetes

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Gene profile correlates with glycemia in type 1 diabetes

March 16, 2012
(HealthDay) -- A gene expression profile in peripheral blood correlates with glycemic control in the first year for patients recently diagnosed with type 1 diabetes, according to a study published online March 8 in Diabetes.

Researchers investigate link between autoimmune diseases and wounds that don't heal

November 6, 2011
Millions of Americans suffer from wounds that don't heal, and while most are typically associated with diabetes, new research has identified another possible underlying cause – autoimmune diseases. The finding represents ...

Recommended for you

Personalized blood sugar goals can save diabetes patients thousands

December 11, 2017
A cost analysis by researchers at the University of Chicago Medicine shows treatment plans that set individualized blood sugar goals for diabetes patients, tailored to their age and health history, can save $13,546 in health ...

Kidney disease increases risk of diabetes, study shows

December 11, 2017
Diabetes is known to increase a person's risk of kidney disease. Now, a new study from Washington University School of Medicine in St. Louis suggests that the converse also is true: Kidney dysfunction increases the risk of ...

Type 2 diabetes is not for life

December 5, 2017
Almost half of the patients with Type 2 diabetes supported by their GPs on a weight loss programme were able to reverse their diabetes in a year, a study has found.

Skipping breakfast disrupts 'clock genes' that regulate body weight

November 30, 2017
Irregular eating habits such as skipping breakfast are often associated with obesity, type 2 diabetes, hypertension and cardiovascular disease, but the precise impact of meal times on the body's internal clock has been less ...

Type 2 diabetes has hepatic origins

November 28, 2017
Affecting as many as 650 million people worldwide, obesity has become one of the most serious global health issues. Among its detrimental effects, it increases the risk of developing metabolic conditions, and primarily type ...

Critical link between obesity and diabetes has been identified

November 28, 2017
UT Southwestern researchers have identified a major mechanism by which obesity causes type 2 diabetes, which is a common complication of being overweight that afflicts more than 30 million Americans and over 400 million ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.