New weekly fertility injections work as well as daily

June 12, 2012, Wiley

New long-lasting weekly injections of fertility hormones are as safe and effective as standard daily injections, according to Cochrane researchers. The researchers compared weekly and daily hormone injections in a Cochrane systematic review and found no difference in pregnancies or serious side effects between the two regimens.

Women undergoing are usually given daily injections of follicle stimulating hormone (FSH) to increase the number of eggs that their ovaries release each month. In in vitro (IVF) and (ICSI), the eggs are then removed and fertilised outside the body. Daily hormone injections can be painful and stressful but a new longer-lasting FSH, known as corifollitropin alfa, has recently been introduced. One injection of this longer-lasting hormone can replace the first seven days of FSH injections required in the standard .

The researchers included data from four trials involving 2,335 people in their review. They show that women given medium doses of the new long-lasting hormone on a weekly basis are equally likely to become pregnant and are no more likely to have a miscarriage or than those receiving daily FSH injections.

"These results show that the new long-acting injections are a safe treatment option and equally effective in medium doses compared to the standard daily injections," said Jan Kremer, one of the authors of the review based at the Radboud University Nijmegen Medical Center in Nijmegen, Netherlands.

However, there is currently limited information about with long-lasting FSH. "One of the main reasons weekly injections are considered preferable to daily injections is that they are more patient friendly," said Kremer. "So are couples undergoing fertility treatment happier with weekly injections? We would like to see research addressing this question."

Further research is also needed to establish whether long-acting injections are as effective in women who respond poorly to fertility hormones and those who 'hyperrespond', meaning they produce higher than expected numbers of eggs.

Explore further: BPA lowers male fertility: report

More information: Pouwer AW, Farquhar C, Kremer JAM. Long-acting FSH versus daily FSH for women undergoing assisted reproduction. Cochrane Database of Systematic Reviews 2012, Issue 6. Art. No.: CD009577. DOI: 10.1002/14651858.CD009577.pub2

Related Stories

BPA lowers male fertility: report

June 6, 2011
Daily exposure to a chemical that is prevalent in the human environment, bisphenol A (BPA), causes lowered fertility in male mice, according to the results of a new study that will be presented Saturday at The Endocrine Society's ...

Recommended for you

New study reveals time and day women are most likely to give birth

June 15, 2018
A new study has found that the time and day that women give birth can vary significantly depending on how labour starts and the mode of giving birth.

Blood test for pregnant women can predict premature birth

June 7, 2018
A new blood test for pregnant women detects with 75-80 percent accuracy whether their pregnancies will end in premature birth. The technique can also be used to estimate a fetus's gestational age—or the mother's due date—as ...

Drug combination offers more effective care for patients suffering miscarriage

June 6, 2018
A combination of the drugs mifepristone and misoprostol can help bring closure to some women and their families suffering from miscarriage, and reduces the need for surgical intervention to complete the painful miscarriage ...

Genes, environment and schizophrenia—new study finds the placenta is the missing link

May 28, 2018
Hiding in plain sight, new research shines a spotlight on the placenta's critical role in the nature versus nurture debate and how it confers risk for schizophrenia and likely other neurodevelopmental disorders including ...

Vendors say pot eases morning sickness. Will baby pay a price?

May 22, 2018
(HealthDay)—Nearly 70 percent of Colorado marijuana dispensaries recommended pot products to manage early pregnancy-related morning sickness, new research reveals.

Pregnancy drug DES might have triggered ADHD in the grandchildren of women who used it

May 21, 2018
A study conducted by researchers at Columbia University's Mailman School of Public Health and Harvard T.H. Chan School of Public Health reported elevated odds for attention deficit hyperactivity disorder (ADHD) in the grandchildren ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.