Children continue to be underrepresented in drug trials

July 23, 2012
Children continue to be underrepresented in drug trials
Even for conditions with a high pediatric disease burden, only a small proportion of clinical drug trials study pediatric patients, according to research published online July 23 in Pediatrics.

(HealthDay) -- Even for conditions with a high pediatric disease burden, only a small proportion of clinical drug trials study pediatric patients, according to research published online July 23 in Pediatrics.

Florence T. Bourgeois, M.D., M.P.H., from Harvard University in Boston, and colleagues identified all registered in with start dates between 2006 and 2011 and tracked the resulting publications for conditions with a high burden of pediatric disease.

The researchers found that, for the selected conditions, 59.9 percent of the disease burden was seen in children, but only 292 of 2,440 trials (12.0 percent) were for (P < 0.001). Trials conducted without industry funding were significantly more common in pediatric populations compared with adults (58.6 versus 35.0 percent). Pediatric randomized trials were significantly less likely to examine safety outcomes compared with adult randomized trials (10.1 versus 16.9 percent) and had a modestly higher probability of publication in the examined time frame (32.8 versus 23.2 percent; P = 0.04).

"There is substantial between pediatric burden of disease and the amount of clinical trial research devoted to pediatric populations," the authors write. "This may be related in part to trial funding, with relying primarily on government and nonprofit organizations."

Explore further: Children neglected in clinical drug trials

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Children neglected in clinical drug trials

April 29, 2012
Although children are more likely than adults to suffer from many diseases, few clinical trials are being conducted to test drugs in pediatric patients, according to a study to be presented Saturday, April 28, at the Pediatric ...

Positive outcome no more likely in industry-funded trials

July 5, 2012
(HealthDay) -- Industry-sponsored clinical trials of rheumatoid arthritis drugs are no more likely to report positive outcomes than trials funded by other means, and in many cases use better methodology, according to research ...

Pediatric regime of chemotherapy proves more effective for young adults

June 18, 2012
Acute lymphoblastic leukemia (ALL), usually found in pediatric patients, is far more rare and deadly in adolescent and adult patients. According to the National Marrow Donor Program, child ALL patients have a higher than ...

Recommended for you

Is rushing your child to the ER the right response?

October 16, 2017
If a child gets a small burn from a hot pan, starts choking or swallows medication, parents may struggle to decide whether to provide first aid at home or rush them to the hospital, suggests a new national poll.

Happier mealtimes, healthier eating for kids

October 13, 2017
(HealthDay)—Parents who struggle to get their children to follow a healthy diet may want to make dinnertime a pleasant experience, new research suggests.

Children born prematurely have greater risk of cognitive difficulties later in life

October 11, 2017
Babies born preterm have a greater risk of developing cognitive, motor and behavioural difficulties and these problems persist throughout school years, finds a new study led by Queen Mary University of London (QMUL).

Helping preemies avoid unnecessary antibiotics

October 5, 2017
(HealthDay)—Researchers say they have identified three criteria that suggest an extremely premature infant has a low risk of developing sepsis, which might allow doctors to spare these babies early exposure to antibiotics.

Got a picky eater? How 'nature and nurture' may be influencing eating behavior in young children

October 3, 2017
For most preschool-age children, picky eating is just a normal part of growing up. But for others, behaviors such as insisting on only eating their favorite food item—think chicken nuggets at every meal—or refusing to ...

Anxious moms may give clues about how anxiety develops

September 27, 2017
Moms may be notorious worriers, but babies of anxious mothers may also spend more time focusing on threats in their environment, according to a team of researchers.


Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.