Five CSF markers differentiate dementia, parkinsonism

August 28, 2012
Five CSF markers differentiate dementia, parkinsonism
Levels of five different cerebrospinal fluid biomarkers are able to improve differentiation between common dementia and parkinsonian disorders, according to a study published online Aug. 27 in the Archives of Neurology.

(HealthDay)—Levels of five different cerebrospinal fluid (CSF) biomarkers are able to improve differentiation between common dementia and parkinsonian disorders, according to a study published online Aug. 27 in the Archives of Neurology.

Sara Hall, M.D., from Lund University in Sweden, and colleagues assessed the ability of five CSF biomarkers to differentiate between 453 CSF samples from healthy controls and patients with Parkinson's disease (PD), PD with dementia (PDD), dementia with Lewy bodies (DLB), Alzheimer's disease (AD), progressive supranuclear palsy (PSP), multiple system atrophy (MSA), or corticobasal degeneration (CBD).

The researchers found that CSF levels of α-synuclein were increased in patients with AD and decreased in patients with PD, PDD, DLB, and MSA. Decreased levels of β-amyloid 1-42 were seen in DLB. In AD, β-amyloid 1-42 levels were further decreased and CSF levels of total tau and hyperphosphorylated tau were increased. These biomarkers were able to distinguish AD from DLB and PDD with an area under the curve of 0.90, with the main contribution from α-synuclein and total tau. In atypical parkinsonian disorders (PSP, MSA, and CBD), CSF levels of neurofilament light chain were increased, and that level alone could be used to differentiate PD from atypical parkinsonian disorders with an area under the curve of 0.93.

"Together with earlier published data, our results indicate that these five CSF might have clinical value in the differential diagnosis of and/or parkinsonism," Hall and colleagues conclude.

Explore further: Changes seen in cerebrospinal fluid levels before onset of Alzheimer dementia

More information: Abstract
Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Related Stories

Changes seen in cerebrospinal fluid levels before onset of Alzheimer dementia

January 2, 2012
Cerebrospinal fluid levels of Aβ42 appear to be decreased at least five to 10 years before some patients with mild cognitive impairment develop Alzheimer disease (AD) dementia whereas other spinal fluid levels seem to ...

Study examines immunotherapy and cerebrospinal fluid biomarkers in patients with Alzheimer's disease

April 2, 2012
Immunotherapy with the antibody bapineuzumab in patients with mild to moderate Alzheimer disease resulted in decreases in a cerebrospinal fluid biomarker, which may indicate downstream effects on the degenerative process, ...

Study examines relationship between two proteins associated with Alzheimer's disease

April 23, 2012
A study that examined the relationship between two cerebrospinal fluid proteins associated with Alzheimer disease in clinically and cognitively normal older patients suggests that amyloid-β (Αβ)-associated ...

Clinical trial examines antioxidant effects for Alzheimer's disease on cerebrospinal fluid biomarkers

March 19, 2012
An antioxidant combination of vitamin E, vitamin C and α-lipoic acid (E/C/ALA) was not associated with changes in some cerebrospinal fluid biomarkers related to Alzheimer disease in a randomized controlled trial, according ...

New findings, imaging may aid diagnosis of concomitant AD in patients with Parkinson's disease dementia

April 16, 2012
Dementia is a frequent complication of Parkinson's disease (PD), but it is clinically impossible to distinguish PD dementia (PDD), which develops from the progression of the Lewy body pathology that underlies PD, from PD ...

Range of diagnostic spinal fluid tests needed to differentiate concurrent brain diseases

April 20, 2012
Teasing out the exact type or types of dementia someone suffers from is no easy task; neurodegenerative brain diseases share common pathology and often co-occur. Researchers from the Perelman School of Medicine at the University ...

Recommended for you

'Selfish brain' wins out when competing with muscle power, study finds

October 20, 2017
Human brains are expensive - metabolically speaking. It takes lot of energy to run our sophisticated grey matter, and that comes at an evolutionary cost.

Brain training can improve our understanding of speech in noisy places

October 19, 2017
For many people with hearing challenges, trying to follow a conversation in a crowded restaurant or other noisy venue is a major struggle, even with hearing aids. Now researchers reporting in Current Biology on October 19th ...

Researchers find shifting relationship between flexibility, modularity in the brain

October 19, 2017
A new study by Rice University researchers takes a step toward what they see as key to the advance of neuroscience: a better understanding of the relationship between the brain's flexibility and its modularity.

Investigating the most common genetic contributor to Parkinson's disease

October 19, 2017
LRRK2 gene mutations are the most common genetic cause of Parkinson's disease (PD), but the normal physiological role of this gene in the brain remains unclear. In a paper published in Neuron, Brigham and Women's Hospital ...

Brain takes seconds to switch modes during tasks

October 19, 2017
The brain rapidly switches between operational modes in response to tasks and what is replayed can predict how well a task will be completed, according to a new UCL study in rats.

New procedure enables cultivation of human brain sections in the petri dish

October 19, 2017
Researchers at the University of Tübingen have become the first to keep human brain tissue alive outside the body for several weeks. The researchers, headed by Dr. Niklas Schwarz, Dr. Henner Koch and Dr. Thomas Wuttke at ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.