New study evaluates noninvasive technology to determine heart disease

August 29, 2012

A study published in the most recent issue of the Journal of the American Medical Association (JAMA) presented encouraging news regarding physicians' ability to determine blood flow and associated coronary artery disease (CAD) using noninvasive CT scanning technology. Data from the Determination of Fractional Flow Reserve by Anatomic Computed Tomographic Angiography (DeFACTO) study were presented on August 26 at the European Society of Cardiology Congress in Munich, Germany. John R. Lesser, MD, a Cardiologist and senior researcher at the Minneapolis Heart Institute Foundation, served as a principal investigator for the DeFACTO study and Minneapolis Heart Institute Foundation Cardiologist and senior researcher Robert Schwartz, MD directed the Integration Core Lab coordinating data from 17 sites worldwide.

"The study showed improved diagnostic accuracy with CT scanning when we also use a new technique called fractional flow reserve that identifies the rate of and possible blockages in the arteries that may interfere with flow," said Robert Schwartz, MD.

Fractional (FFR) has been identified as a procedure that may help to reduce unnecessary angiography and stenting when used. It requires a minimally invasive procedure. FFR with CT scanning requires no invasive procedure and has the potential to deliver equally useful data.

The objective of the DeFACTO study was to assess the diagnostic performance of CT with and without FFR for diagnosis of significant coronary stenosis. In its conclusion, the use of noninvasive FFRCT among patients with CAD was associated with improved diagnostic accuracy and discrimination.

"DeFACTO is worthy of note because, while it did not achieve it's endpoint, it definitely showed improved diagnostic accuracy using FFRCT vs. CT alone," stated Schwartz. "We are always looking to use the least invasive procedures to get the best results and DeFACTO indicates that we may soon have another useful tool in evaluating and treating heart disease."

In an editorial in JAMA, Manesh R. Patel, MD, Duke Clinical Research Institute, Duke University Medical Center, wrote, "The current report describes an important noninvasive technology that may improve existing care and has the potential to outperform established noninvasive technologies."

DeFACTO is a multi-center diagnostic performance study involving 252 stable patients with suspected or known CAD from 17 centers in 5 countries who underwent CT, invasive coronary angiography (ICA), FFR, and FFRCT between October 2010 and October 2011. The primary study outcome assessed whether FFRCT plus CT could improve the per-patient diagnostic accuracy. Among study participants and compared with obstructive CAD diagnosed by CT alone, FFRCT was associated with improved and discrimination.

Explore further: Non-invasive fractional flow reserve in the identification of flow-restricting arterial blockage

More information: The article in JAMA can be found here: jama.jamanetwork.com/article.a … px?articleid=1352969

Related Stories

Non-invasive fractional flow reserve in the identification of flow-restricting arterial blockage

August 27, 2012
Data presented today from the prospective Determination of Fractional Flow Reserve by Anatomic Computed Tomographic Angiography (DeFACTO) study show that, when compared to standard coronary angiography (CT), the non-invasive ...

Diagnostic test shows potential to noninvasively identify significant coronary artery disease

August 26, 2012
Among patients with suspected or known coronary artery disease, use of a method that applies computational fluid dynamics to derive certain data from computed tomographic (CT) angiography demonstrated improved diagnostic ...

CT angiography and perfusion to assess coronary artery disease: The CORE320 study

August 28, 2012
A non-invasive imaging strategy which integrates non-invasive CT angiography (CTA) and CT myocardial perfusion imaging (CTP) has robust diagnostic accuracy for identifying patients with flow-limiting coronary artery disease ...

PCI guided by fractional flow reserve versus medical therapy alone in stable coronary disease

August 28, 2012
Patients with stable coronary artery disease (CAD) had a lower need for urgent revascularisation when receiving fractional flow reserve (FFR)-guided PCI plus the best available medical therapy (MT) than when receiving MT ...

Recommended for you

Some cancer therapies may provide a new way to treat high blood pressure

November 20, 2017
Drugs designed to halt cancer growth may offer a new way to control high blood pressure (hypertension), say Georgetown University Medical Center investigators. The finding could offer a real advance in hypertension treatment ...

Could this protein protect people against coronary artery disease?

November 17, 2017
The buildup of plaque in the heart's arteries is an unfortunate part of aging. But by studying the genetic makeup of people who maintain clear arteries into old age, researchers led by UNC's Jonathan Schisler, PhD, have identified ...

Raising 'good' cholesterol fails to protect against heart disease

November 16, 2017
Raising so-called 'good' cholesterol by blocking a key protein involved in its metabolism does not protect against heart disease or stroke, according to a large genetic study of 150,000 Chinese adults published in the journal ...

Popular e-cigarette liquid flavorings may change, damage heart muscle cells

November 16, 2017
Chemicals used to make some popular e-cigarette liquid flavorings—including cinnamon, clove, citrus and floral—may cause changes or damage to heart muscle cells, new research indicates.

New model estimates odds of events that trigger sudden cardiac death

November 16, 2017
A new computational model of heart tissue allows researchers to estimate the probability of rare heartbeat irregularities that can cause sudden cardiac death. The model, developed by Mark Walker and colleagues from Johns ...

Possible use for botulinum toxin to treat atrial fibrillation

November 16, 2017
From temporarily softening wrinkles to easing migraines, botulinum toxin has become a versatile medical remedy because of its ability to block nerve signals that can become bothersome or risky.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.