Woman gets new heart, kidney despite the odds

August 10, 2012 By Amy Albin, University of California, Los Angeles
Osborne and her grandmother

At age 32, Brandie Osborne has beaten the odds.

The young woman from Compton, Calif., has dealt with health issues her entire life and has faced death more than once. But now, with a new donated heart and kidney, transplanted at Ronald Reagan UCLA Medical Center, she has been given a second chance to live and is ready to take on the world.

Osborne was born with a fairly common genetic condition known as Noonan syndrome, which is often associated with heart and lung problems. In Osborne's case, she developed hypertrophic cardiomyopathy, a thickening of the heart muscle, and pulmonary hypertension, which caused high blood pressure in her lungs. In 2009, her condition worsened and she was placed on the waiting list for a heart–lung transplant at a hospital in Northern California that was covered by her insurance.

While waiting, she suffered heart and lung failure and required a breathing tube. Then her kidneys failed and she needed dialysis. With so many medical complications, she was deemed an unacceptable candidate for transplantation surgery and was transferred back to UCLA to pursue end-of-life care.

Osborne spent the next six months in the intensive care unit at UCLA and slowly improved, ultimately learning to walk and function again. In March 2010, she was well enough to go home with the aid of several machines that helped her breathe and eat. Despite her chronic heart and kidney failure, her spirit endured and her health continued to improve with the love and support of family and friends.

Over the next two years, Osborne's extremely complicated medical issues kept her from being considered for a transplant again. However, her lung doctor, Dr. David Ross, a professor of pulmonology and medical director of the UCLA Lung Transplant Program, and her cardiologist, Dr. Daniel Cruz, a clinical instructor of cardiology at UCLA, championed a new idea: If they used medications to treat Osborne's pulmonary hypertension after a potential heart transplant, she would not require a lung transplant at the same time. In other words, the lung problems could be reversed with a healthy new heart and medications. Pursuing this strategy, they hoped, could get Osborne back on the transplant list for a heart, and possibly a kidney.

"Although it would be unchartered territory, after much intense discussion among the team and after explaining the high risks to Brandie and her family, it was decided to put her on the combined heart and kidney transplant list in June 2012," Ross said.

Thirty-six days later, Brandie learned that an organ donor had been found. She said her reaction was, "No way! Oh my God! Oh my God," followed by tears, then panic, then more tears and excitement.

Going into the first phase of the surgery — the heart transplant — Osborne had been told it was an extremely high-risk operation. One of the scariest parts, she said, was that she'd been told by the doctors that because of her anatomy, the surgeon might not be able to immediately close her chest wall after the new heart was transplanted. There was a likelihood she would have to remain in intensive care with her chest open and possibly use an oxygenation machine to support the new heart.

However, Dr. Richard Shemin, UCLA's chief of cardiothoracic surgery, successfully performed the delicate operation and managed to close Osborne's chest without complications. Less than 24 hours later, she returned to the UCLA operating room for the next phase, a kidney transplant from the same donor, which was performed by Dr. H. Albin Gritsch, an associate professor of urology.

When she woke up after the two high-risk surgeries, the first thing she said to her mother was, "I'm alive!"

Osborne is now going home from the hospital in just her "skin" — no tubes, no machines, no dialysis. She has just one small pump that administers her lung medications.

"Thanks to the family who made the decision to donate their loved one's organs, I am getting a second chance at life," she said. "I cannot thank my donor and my UCLA team enough for saving my life!"

And her list of things to do is quite long: swim, ride a bike, go for walks, play with her Shitzu puppy, travel to Hawaii, eat lots of pasta, and learn how to bake cupcakes and someday open a bakery.

Explore further: Patient's lifesaving donor heart arrives 'warm and beating' inside experimental device

More information: For more information on organ donation, please visit www.donatelife.net

Related Stories

Patient's lifesaving donor heart arrives 'warm and beating' inside experimental device

August 30, 2011
(Medical Xpress) -- When Rob Evans' new donor heart arrived at Ronald Reagan UCLA Medical Center, the organ wasn't frozen on ice inside a cooler, as is typical. Instead, it was delivered in an experimental device that kept ...

Lung transplant recipient defies all odds

July 6, 2012
Meara Schmidt, 28, almost died a few weeks ago. Lying in her hospital bed at UCLA, the seriously ill cystic fibrosis patient felt herself slipping away and her life flashing by. But then the image of her husband appeared, ...

'Hybrid' surgery saves UCLA patient from softball-sized aneurysm

April 13, 2012
Patricia Crawford had literally been tinged blue all her life because her heart couldn’t pump enough oxygenated blood through her body. And that was the least of her worries.

Home monitoring may help manage and reduce costs for heart failure

January 3, 2012
(Medical Xpress) -- Heart failure affects 5.8 million people in the U.S. alone and is responsible for nearly 1 million hospitalizations each year, most resulting from a build-up of body fluid in the lungs and other organs ...

UCLA docs guide mom with heart condition through birth, operate on newborn

February 14, 2012
Keyota Cole was born with a bad heart. The 33-year-old from of Bakersfield, Calif., suffers from a congenital heart disease called Ebstein's malformation of the tricuspid valve, and from abnormal pulmonary veins. She ...

St. Michael's North America first to use novel blood-cleaning procedure for kidney transplant

July 26, 2011
St. Michael's Hospital today became the first in North America to use a novel blood-cleaning procedure for a kidney patient that will allow him to receive a transplant from a donor with a different blood type.

Recommended for you

Best of Last Year—The top Medical Xpress articles of 2017

December 20, 2017
It was a good year for medical research as a team at the German center for Neurodegenerative Diseases, Magdeburg, found that dancing can reverse the signs of aging in the brain. Any exercise helps, the team found, but dancing ...

Pickled in 'cognac', Chopin's heart gives up its secrets

November 26, 2017
The heart of Frederic Chopin, among the world's most cherished musical virtuosos, may finally have given up the cause of his untimely death.

Sugar industry withheld evidence of sucrose's health effects nearly 50 years ago

November 21, 2017
A U.S. sugar industry trade group appears to have pulled the plug on a study that was producing animal evidence linking sucrose to disease nearly 50 years ago, researchers argue in a paper publishing on November 21 in the ...

Female researchers pay more attention to sex and gender in medicine

November 7, 2017
When women participate in a medical research paper, that research is more likely to take into account the differences between the way men and women react to diseases and treatments, according to a new study by Stanford researchers.

Drug therapy from lethal bacteria could reduce kidney transplant rejection

August 3, 2017
An experimental treatment derived from a potentially deadly microorganism may provide lifesaving help for kidney transplant patients, according to an international study led by investigators at Cedars-Sinai.

Exploring the potential of human echolocation

June 25, 2017
People who are visually impaired will often use a cane to feel out their surroundings. With training and practice, people can learn to use the pitch, loudness and timbre of echoes from the cane or other sounds to navigate ...


Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.