Skin cancer incidence up after pancreas transplantation

September 21, 2012
Skin cancer incidence up after pancreas transplantation
Nonmelanoma skin cancers commonly occur after pancreas transplantation, particularly in those who have a history of skin cancer, according to a study published in the October issue of the Journal of the American Academy of Dermatology.

(HealthDay)—Nonmelanoma skin cancers (NMSCs) commonly occur after pancreas transplantation (PT), particularly in those who have a history of skin cancer, according to a study published in the October issue of the Journal of the American Academy of Dermatology.

Joshua P. Spanogle, M.D., of the Mayo Clinic in Rochester, Minn., and colleagues conducted a retrospective study involving 216 patients who had received allogeneic PT. Recipients were assessed at two, five, and 10 years after transplantation to evaluate the incidence, , and risk factors for skin cancer.

The researchers found that the cumulative incidence of any skin cancer was 4.7 percent at two years post-transplantation; 12.7 percent at five years; and 19.6 percent at 10 years. The cumulative incidence of squamous cell carcinoma was 2.8, 10.3, and 16.7 percent, respectively, and the cumulative incidence of basal cell carcinoma was 2.4, 7.8, and 17.4 percent, respectively. At two years, the cumulative incidence of developing a second or was 56 and 36 percent, respectively. The only predictors of skin cancer were patient age and a history of skin cancer prior to transplant.

"In light of the substantively increased risk both for primary skin cancers and for subsequent NMSCs in the PT population, preventive and mitigating measures are crucial," the authors write. "Frequent evaluation of PT recipients by a health care professional trained in evaluating skin pathology is important in lessening the effect of NMSC, which is more easily treated in the early course of the disease."

Explore further: Increased tanning bed use increases risk for deadly skin cancers

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Increased tanning bed use increases risk for deadly skin cancers

October 24, 2011
Researchers confirmed an association between tanning bed use and an increased risk for three common skin cancers — basal cell carcinoma, squamous cell carcinoma and melanoma, according to results presented at the 10th ...

Immunosuppressant switch cuts skin cancer post-transplant

July 26, 2012
(HealthDay) -- In kidney-transplant patients with at least one cutaneous squamous-cell carcinoma, switching immunosuppressants (from calcineurin inhibitors to sirolimus) is associated with increased skin cancer-free survival ...

More accurate method required for tracking skin cancer cases: study

April 5, 2012
Henry Ford Hospital dermatology researchers are urging caution about using claims data for identifying nonmelanoma skin cancer, suggesting that the commonly used method, which previously had not been validated, may be unreliable.

Study suggests link between smoking, increased risk of cutaneous squamous cell carcinoma

June 18, 2012
Smoking appears to be associated with an increased risk of cutaneous squamous cell carcinoma skin cancer, according to a report of a meta-analysis and review of available medical literature published Online First by Archives ...

Recommended for you

T-cells engineered to outsmart tumors induce clinical responses in relapsed Hodgkin lymphoma

January 16, 2018
WASHINGTON-(Jan. 16, 2018)-Tumors have come up with ingenious strategies that enable them to evade detection and destruction by the immune system. So, a research team that includes Children's National Health System clinician-researchers ...

Researchers identify new treatment target for melanoma

January 16, 2018
Researchers in the Perelman School of Medicine at the University of Pennsylvania have identified a new therapeutic target for the treatment of melanoma. For decades, research has associated female sex and a history of previous ...

More evidence of link between severe gum disease and cancer risk

January 16, 2018
Data collected during a long-term health study provides additional evidence for a link between increased risk of cancer in individuals with advanced gum disease, according to a new collaborative study led by epidemiologists ...

Researchers develop a remote-controlled cancer immunotherapy system

January 15, 2018
A team of researchers has developed an ultrasound-based system that can non-invasively and remotely control genetic processes in live immune T cells so that they recognize and kill cancer cells.

Dietary fat, changes in fat metabolism may promote prostate cancer metastasis

January 15, 2018
Prostate tumors tend to be what scientists call "indolent" - so slow-growing and self-contained that many affected men die with prostate cancer, not of it. But for the percentage of men whose prostate tumors metastasize, ...

Pancreatic tumors may require a one-two-three punch

January 15, 2018
One of the many difficult things about pancreatic cancer is that tumors are resistant to most treatments because of their unique density and cell composition. However, in a new Wilmot Cancer Institute study, scientists discovered ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.