Skin cancer incidence up after pancreas transplantation

September 21, 2012
Skin cancer incidence up after pancreas transplantation
Nonmelanoma skin cancers commonly occur after pancreas transplantation, particularly in those who have a history of skin cancer, according to a study published in the October issue of the Journal of the American Academy of Dermatology.

(HealthDay)—Nonmelanoma skin cancers (NMSCs) commonly occur after pancreas transplantation (PT), particularly in those who have a history of skin cancer, according to a study published in the October issue of the Journal of the American Academy of Dermatology.

Joshua P. Spanogle, M.D., of the Mayo Clinic in Rochester, Minn., and colleagues conducted a retrospective study involving 216 patients who had received allogeneic PT. Recipients were assessed at two, five, and 10 years after transplantation to evaluate the incidence, , and risk factors for skin cancer.

The researchers found that the cumulative incidence of any skin cancer was 4.7 percent at two years post-transplantation; 12.7 percent at five years; and 19.6 percent at 10 years. The cumulative incidence of squamous cell carcinoma was 2.8, 10.3, and 16.7 percent, respectively, and the cumulative incidence of basal cell carcinoma was 2.4, 7.8, and 17.4 percent, respectively. At two years, the cumulative incidence of developing a second or was 56 and 36 percent, respectively. The only predictors of skin cancer were patient age and a history of skin cancer prior to transplant.

"In light of the substantively increased risk both for primary skin cancers and for subsequent NMSCs in the PT population, preventive and mitigating measures are crucial," the authors write. "Frequent evaluation of PT recipients by a health care professional trained in evaluating skin pathology is important in lessening the effect of NMSC, which is more easily treated in the early course of the disease."

Explore further: Increased tanning bed use increases risk for deadly skin cancers

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Increased tanning bed use increases risk for deadly skin cancers

October 24, 2011
Researchers confirmed an association between tanning bed use and an increased risk for three common skin cancers — basal cell carcinoma, squamous cell carcinoma and melanoma, according to results presented at the 10th ...

Immunosuppressant switch cuts skin cancer post-transplant

July 26, 2012
(HealthDay) -- In kidney-transplant patients with at least one cutaneous squamous-cell carcinoma, switching immunosuppressants (from calcineurin inhibitors to sirolimus) is associated with increased skin cancer-free survival ...

More accurate method required for tracking skin cancer cases: study

April 5, 2012
Henry Ford Hospital dermatology researchers are urging caution about using claims data for identifying nonmelanoma skin cancer, suggesting that the commonly used method, which previously had not been validated, may be unreliable.

Study suggests link between smoking, increased risk of cutaneous squamous cell carcinoma

June 18, 2012
Smoking appears to be associated with an increased risk of cutaneous squamous cell carcinoma skin cancer, according to a report of a meta-analysis and review of available medical literature published Online First by Archives ...

Recommended for you

Physical activity could combat fatigue, cognitive decline in cancer survivors

July 25, 2017
A new study indicates that cancer patients and survivors have a ready weapon against fatigue and "chemo brain": a brisk walk.

Breaking the genetic resistance of lung cancer and melanoma

July 25, 2017
Researchers from Monash University and the Memorial Sloan Kettering Cancer Center (MSKCC, New York) have discovered why some cancers – particularly lung cancer and melanoma – are able to quickly develop deadly resistance ...

Anti-cancer chemotherapeutic agent inhibits glioblastoma growth and radiation resistance

July 24, 2017
Glioblastoma is a primary brain tumor with dismal survival rates, even after treatment with surgery, chemotherapy and radiation. A small subpopulation of tumor cells—glioma stem cells—is responsible for glioblastoma's ...

New therapeutic approach for difficult-to-treat subtype of ovarian cancer identified

July 24, 2017
A potential new therapeutic strategy for a difficult-to-treat form of ovarian cancer has been discovered by Wistar scientists. The findings were published online in Nature Cell Biology.

Immune cells the missing ingredient in new bladder cancer treatment

July 24, 2017
New research offers a possible explanation for why a new type of cancer treatment hasn't been working as expected against bladder cancer.

No dye: Cancer patients' gray hair darkened on immune drugs

July 21, 2017
Cancer patients' gray hair unexpectedly turned youthfully dark while taking novel drugs, and it has doctors scratching their heads.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.