Adhering to lifestyle guidelines reduced mortality in elderly female cancer survivors

October 17, 2012

Achieving and maintaining a healthy body weight, staying physically active and maintaining a healthy diet improved survival after cancer diagnosis in an elderly female cancer survivor population, according to data presented at the 11th Annual AACR International Conference on Frontiers in Cancer Prevention Research, held here Oct. 16-19, 2012.

Researchers examined cancer survivors' adherence to the 2007 World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) guidelines for body weight, physical activity and diet.

"Elderly female who achieve and maintain an ideal body weight, stay physically active and eat a healthy diet have an almost 40 percent lower risk for death compared with women who do not follow these recommendations," said Maki Inoue-Choi, Ph.D., R.D., research associate in the Division of Epidemiology and Community Health in the School of Public Health at the University of Minnesota.

included 2,080 women from the Iowa Women's Health Study who had a confirmed cancer diagnosis between 1986 and 2002 and who completed a follow-up questionnaire in 2004. Women provided information on body weight, physical activity level, dietary intake and other demographic and .

Through annual linkage with the State of Health Registry of Iowa and the National Death Index, researchers identified 495 deaths from 2004 to 2009, including 197 from cancer and 153 from cardiovascular disease. Researchers adjusted for age, number of , general health, smoking, type and stage of cancer, current cancer treatment and subsequent . They found all-cause mortality was 37 percent lower for women with the highest (6 to 8) versus the lowest (0 to 4) adherence scores.

Reaching the WCRF/AICR physical activity recommendation was also associated with lower risk for death from any cause, from cardiovascular disease or from cancer after the researchers adjusted for dietary and body weight recommendation adherence scores and other covariates.

However, reaching the dietary recommendations was not associated with mortality following adjustment for body weight and physical activity recommendation adherence scores.

Explore further: Following cancer prevention guidelines lowers risk of death from cancer, heart disease, all causes

More information: A09 Adherence to the WCRF/AICR recommendations for cancer prevention is associated with all-cause and cancer mortality among elderly female cancer survivors. Maki Inoue-Choi, DeAnn Lazovich, Kim Robien. University of Minnesota, Minneapolis, MN.

Abstract
Background: Lifestyle recommendations to decrease risk of primary cancer such as eating a healthy diet, maintaining ideal body weight and staying physically active may also decrease risk of subsequent cancers and other chronic disease. The 2007 World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) body weight, physical activity and dietary guidelines encourage cancer survivors to follow its cancer prevention recommendations. However, the quantity and quality of research available to support evidence-based recommendations specific to cancer survivors are deemed to be insufficient.

Methods: A total of 2,080 participants in the Iowa Women's Health Study who had a confirmed cancer diagnosis between 1986 and 2002 and completed the follow-up questionnaire in 2004 were included in analysis. Dietary intake, body weight, and physical activity level, as well as other demographic and lifestyle factors were collected in the 2004 survey. An adherence score to the 2007 WCRF/AICR recommendations (range: 0) was calculated assigning one point each of eight recommendations. Vital status and cause of deaths were collected through annual linkage with the State of Health Registry of Iowa and the National Death Index. Multivariate hazard ratios (HR) and 95% confidence intervals (CI) of cancer, cardiovascular disease (CVD), and all-cause mortality were computed for quartiles of adherence scores by Cox regression proportional hazard regression models. Mortality was also compared by body weight, physical activity, or dietary recommendation adherence scores.

Results: From 2004 through 2009, 495 deaths were identified, including 197 due to cancer and 153 due to CVD. All-cause mortality was lower for women with the highest (6-8) versus lowest (0-4) adherence scores (HR=0.63, 95%CI=0.47-0.85) after adjusting for age, number of comorbid conditions, perceived general health, current smoking, type and stage of cancer, type of cancer treatment, current cancer treatment and subsequent cancer diagnosis. When stratifying by time since diagnosis or cancer type, this inverse association was confined to women who survived 5-10 y, survivors of breast cancer, and survivors in the "other cancers" category (cancers other than breast, colorectal and endometrial cancers). Similarly, cancer mortality was lower among women with the highest versus lowest adherence scores (HR=0.55, 95%CI=0.34-0.90), but only among survivors in the "other cancers" category. CVD mortality was not different by adherence scores. Meeting the physical activity recommendation was associated with lower risk of death from any cause (ptrend<0.0001), CVD (ptrend=0.045) and cancer (ptrend=0.01) after adjusting for dietary and body weight recommendation adherence scores and other covariates. Meeting the dietary recommendations was not associated with mortality after adjusting for physical activity recommendation adherence scores.

Conclusions: Adherence to lifestyle recommendations to prevent primary cancers may improve all-cause and cancer mortality among elderly female cancer survivors. Being physically active appears to have a strong and independent association with lower mortality among elderly cancer survivors.

Related Stories

Following cancer prevention guidelines lowers risk of death from cancer, heart disease, all causes

April 14, 2011
A study of more than 100,000 men and women over 14 years finds nonsmokers who followed recommendations for cancer prevention had a lower risk of death from cancer, cardiovascular disease, and all-causes. The study appears ...

Guidelines say diet, exercise, weight control improve odds after cancer diagnosis

April 26, 2012
New guidelines from the American Cancer Society say for many cancers, maintaining a healthy weight, getting adequate physical activity, and eating a healthy diet can reduce the chance of recurrence and increase the likelihood ...

Recommended for you

Drug suppresses spread of breast cancer caused by stem-like cells

December 12, 2017
Rare stem-like tumor cells play a critical role in the spread of breast cancer, but a vulnerability in the pathway that powers them offers a strategy to target these cells using existing drugs before metastatic disease occurs, ...

MRI scans predict patients' ability to fight the spread of cancer

December 12, 2017
A simple, non-invasive procedure that can indicate how long patients with cancer that has spread to the brain might survive and whether they are likely to respond to immunotherapy has been developed by researchers in Liverpool.

A new weapon against bone metastasis? Team develops antibody to fight cancer

December 11, 2017
In the ongoing battle between cancer and modern medicine, some therapeutic agents, while effective, can bring undesirable or even dangerous side effects. "Chemo saves lives and improves survival, but it could work much better ...

Insights on how SHARPIN promotes cancer progression

December 11, 2017
Researchers at Sanford Burnham Prebys Medical Discovery (SBP) and the Technion in Israel have found a new role for the SHARPIN protein. In addition to being one of three proteins in the linear ubiquitin chain assembly complex ...

Glioblastoma survival mechanism reveals new therapeutic target

December 11, 2017
A Northwestern Medicine study, published in the journal Cancer Cell, has provided new insights into a mechanism of tumor survival in glioblastoma and demonstrated that inhibiting the process could enhance the effects of radiation ...

Liver cancer: Lipid synthesis promotes tumor formation

December 11, 2017
Lipids comprise an optimal energy source and an important cell component. Researchers from the Biozentrum of the University of Basel and from the University of Geneva have now discovered that the protein mTOR stimulates the ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.