Filaggrin mutations up risk of irritant contact dermatitis

October 14, 2012
Filaggrin mutations up risk of irritant contact dermatitis
Both atopic dermatitis and loss-of-function mutations in the filaggrin gene are independently associated with an increased risk of developing chronic irritant contact dermatitis, with people having both mutations at about a five-fold higher risk, according to research published online Oct. 5 in the British Journal of Dermatology.

(HealthDay)—Both atopic dermatitis (AD) and loss-of-function mutations in the filaggrin gene (FLG) are independently associated with an increased risk of developing chronic irritant contact dermatitis (ICD), with people having both mutations at about a five-fold higher risk, according to research published online Oct. 5 in the British Journal of Dermatology.

Noting that loss-of-function mutations in FLG increase the risk for AD, Maaike J. Visser, M.D., of the Coronel Institute for Occupational Health in Amsterdam, and colleagues conducted a study involving 634 subjects with chronic ICD and 393 controls to investigate the relative contribution and interaction of FLG mutations and AD in ICD.

The researchers found that 15.9 percent of ICD patients and 8.3 percent of control patients had an FLG mutation, with a crude odds ratio of 2.09 for the combined carrier allele. After correcting for AD, the adjusted odds ratio for FLG mutations was 1.62, and individuals with AD had an odds ratio of 2.89 for developing ICD. Concomitant presence of both AD and FLG mutations resulted in a 4.7-fold increased risk of ICD.

"In summary, our results indicate that both FLG loss-of-function mutations and AD significantly increase the risk for ICD, with respective odds ratios of 1.61 and 2.89," the authors write. "Individuals with both FLG and AD have an approximately four- to five-fold increased risk to develop ICD."

Explore further: ICD-9 codes underestimate statin-linked rhabdomyolysis

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

ICD-9 codes underestimate statin-linked rhabdomyolysis

April 18, 2012
(HealthDay) -- Use of diagnostic codes, such as International Classification of Diseases -- Ninth Revision (ICD-9) codes, may result in misclassification of rare, adverse drug reactions (ADRs), including the risk of rhabdomyolysis ...

Less Alzheimer's pathology with angiotensin receptor blocker use

September 12, 2012
(HealthDay)—In autopsy findings, patients treated with angiotensin receptor blockers (ARBs) show less Alzheimer's disease (AD)-related pathology, according to a study published online Sept. 10 in the Archives of Neurology.

Heart medication converts cancer cells into vaccine

July 23, 2012
(HealthDay) -- A class of heart medications, cardiac glycosides, can induce immunogenic cell death (ICD), whereby dying cancer cells are converted into a vaccine that stimulates antitumor response, according to a study published ...

Recommended for you

Alcohol consumption and metabolic factors act together to increase the risk of severe liver disease

November 22, 2017
A new study provides insights into the interaction between alcohol consumption and metabolic factors in predicting severe liver disease in the general population. The findings, which are published in Hepatology, indicate ...

Gastric acid suppressant lansoprazole may target tuberculosis

November 21, 2017
A cheap and widely used drug, used to treat conditions such as heartburn, gastritis and ulcers, could work against the bacteria that cause tuberculosis (TB), according to new research from UCL and the London School of Hygiene ...

Improving prediction accuracy of Crohn's disease based on repeated fecal sampling

November 21, 2017
Researchers at the University of California San Diego Center for Microbiome Innovation (CMI) have found that sampling the gut microbiome over time can provide insights that are not available with a single time point. The ...

Anti-malaria drug shows promise as Zika virus treatment

November 17, 2017
A new collaborative study led by researchers at Sanford Burnham Prebys Medical Discovery Institute (SBP) and UC San Diego School of Medicine has found that a medication used to prevent and treat malaria may also be effective ...

Decrease in sunshine, increase in Rickets

November 17, 2017
A University of Toronto student and professor have teamed up to discover that Britain's increasing cloudiness during the summer could be an important reason for the mysterious increase in Rickets among British children over ...

Scientists identify biomarkers that indicate likelihood of survival in infected patients

November 17, 2017
Scientists have identified a set of biomarkers that indicate which patients infected with the Ebola virus are most at risk of dying from the disease.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.