Novel chewing gum formulation helps prevent motion sickness

October 17, 2012

A new prototype for medicated chewing gum has been developed for motion sickness that may offer many advantages over conventional oral solid dosage forms. About 33 percent of people are susceptible to motion sickness in mild circumstances and 66 percent are affected in more severe conditions. This research is being presented at the 2012 American Association of Pharmaceutical Scientists (AAPS) Annual Meeting and Exposition in Chicago, Ill., Oct. 14 – 18, an international event anticipating more than 8,000 attendees.

Lead researcher Mohsen Sadatrezaei of RoshaDarou Co. and a team of researchers consisting of Niloufar Pouyan, Zoherh JafariAzar and Alireza Ghaffari from the Islamic Azad University School of (Tehran, Iran), have developed a medicated gum that will improve patient compliance and faster absorption through the cheek, which will alleviate sooner. A sensory panel was used to test faster absorption through the buccal cavity, which will result in earlier onset of action against motion sickness. Panelists also ranked the gum on bitterness and easiness to chew.

"The main challenge in delivering drugs through chewing gum is masking the bitter taste of its active ingredient," said Sadatrezaei. "We have formulated dimenhydrinate as chewing gum with acceptable taste and sensory attributes. Dimenhydrinate is among the best for treatment of motion sickness, providing a comfortable and acceptable drug delivery."

The final formulation has great potential for dimenhydrinate chewing gum commercialization. Moreover, the outcome of the study can be used as a platform to incorporate other active ingredients with objectionable taste into .

Explore further: Spin-out company gets approval for new nicotine gum

Related Stories

Spin-out company gets approval for new nicotine gum

July 14, 2011
A new generation of nicotine gum, developed by the University of Bristol spin-out company Revolymer® Ltd, has been given approval for sale in Canada. The gum uses new technology to mask the nicotine taste.

Recommended for you

Cancer drugs' high prices not justified by cost of development, study contends

September 12, 2017
(HealthDay)— Excusing the sky-high price tags of many new cancer treatments, pharmaceutical companies often blame high research and development (R&D) costs.

Non-psychotropic cannabinoids show promise for pain relief

September 4, 2017
Some cancers love bone. They thrive in its nutrient-rich environment while gnawing away at the very substrate that sustains them, all the while releasing inflammatory substances that cause pain—pain so severe that opioids ...

Fentanyl drives rise in opioid-linked deaths in U.S.

August 31, 2017
(HealthDay)—Fentanyl, a synthetic narcotic, is a key player in America's continuing epidemic of opioid-related overdose deaths, two new studies report.

Eating triggers endorphin release in the brain

August 28, 2017
Finnish researchers have revealed how eating stimulates brain's endogenous opioid system to signal pleasure and satiety.

Cholesterol-lowering drugs may fight infectious disease

August 21, 2017
That statin you've been taking to lower your risk of heart attack or stroke may one day pull double duty, providing protection against a whole host of infectious diseases, including typhoid fever, chlamydia, and malaria.

Data revealed under FOI shows benefits of multiple sclerosis drug currently blocked by regulators

August 17, 2017
A drug that is blocked by the EU regulatory system has now been found to improve the quality of life of people with multiple sclerosis (MS), according to a study by Queen Mary University of London (QMUL).

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.