Life saving surgical technique to be pioneered in Yorkshire

October 23, 2012

A surgical technique which could save the lives of 3,000 colon cancer patients every year will be taught to Yorkshire's surgeons this week in a bid to improve outcomes.

Researchers at the Leeds Institute of Molecular Medicine, part of the University of Leeds' School of Medicine, have spent the past 15 years studying photographic records of bowel removed in the city and around the world in order to compare different types of surgery and how they relate to curing patients.

Initial research into tumours located in the rectum, undertaken by Professor Phil Quirke, led to two training programmes for rectal involving 200 English NHS hospitals. Following further research into tumours located in the colon by Dr Nick West and Professor Quirke, the team will now trial a new training programme in Yorkshire – the first of its kind in the county. If the course, funded by Yorkshire Cancer Research, is successful, it could be rolled out across the UK.

There are 25,000 cases of colon cancer diagnosed in the country each year, and while survival rates for both colon and rectal cancer are slowly improving, colon cancer now has the worst prognosis and the programme aims to change this. New studies by Dr Eva Morris, also from the University of Leeds, have shown a wide variation not only in cure rates but also in death rates after surgery, and her findings will be presented during the two-day course.

Professor Quirke said: "There is wide variation in outcomes for patients with colon cancer across the UK and beyond. Previous studies have shown that by standardising surgery and removing much more tissue surrounding the tumour and ensuring that the specimen removed is more intact, the chance of survival can be increased by 15%.

"Yorkshire currently sits in the middle of the field for outcomes in colon cancer. We would like to improve our position so that we become one of the best in England. We are bringing global leaders in the area to Leeds to share their experiences with surgeons and pathologists and see if we can benefit from their work."

The course will include a presentation by Professor Werner Hohenberger, who is based in Erlangen, Germany, where survival rates are 20% higher than in the UK. Following studies on surgical specimens from Leeds, Dr West compared them to samples from Erlangen, Japan and Denmark and discovered major differences between surgeons and centres.

A training programme based on Hohenberger's technique was recently implemented in Denmark, which has the highest mortality rate for the disease in Western Europe. Based on Dr West's findings, the Danish health authorities carried out a complete retraining of all teams involved in bowel cancer treatment, and although it will be another three years before the impact on five year survival rates is known, the programme proved that clinical practice could be altered through training.

Surgeons from Hillerod Hospital in Denmark and Karolinska University Hospital in Stockholm, who have adopted the technique, will also present as part of the course.

Professor Quirke added: "If we can convince Yorkshire's surgeons to focus on and pioneer these techniques, we will then be able to go to the English NHS with conclusive data from both Denmark and Yorkshire and show them that surgical education could have a major impact on in this country and beyond. If every surgeon in the UK took up this technique, we estimate that 3,000 lives could be saved every year. We wish to ensure that the latest techniques are brought Yorkshire to the benefit Yorkshire patients and ultimately patients elsewhere and thanks to Yorkshire Cancer Research we are able to do so."

Explore further: New study moves researchers closer to lung cancer blood test

Related Stories

New study moves researchers closer to lung cancer blood test

October 15, 2012
Early signs of lung cancer could be diagnosed using a simple blood test following a new discovery by scientists at the University of York.

Elderly breast cancer patients less likely to get surgery

June 17, 2011
(PhysOrg.com) -- University of Manchester researchers, working with colleagues in York, Leeds and Hull, looked at the records of more than 23,000 women with breast cancer diagnosed in the West Midlands, Yorkshire and North ...

Recommended for you

Study prompts new ideas on cancers' origins

December 16, 2017
Rapidly dividing, yet aberrant stem cells are a major source of cancer. But a new study suggests that mature cells also play a key role in initiating cancer—a finding that could upend the way scientists think about the ...

What does hair loss have to teach us about cancer metastasis?

December 15, 2017
Understanding how cancer cells are able to metastasize—migrate from the primary tumor to distant sites in the body—and developing therapies to inhibit this process are the focus of many laboratories around the country. ...

Cancer immunotherapy may work better in patients with specific genes

December 15, 2017
Cancer cells arise when DNA is mutated, and these cells should be recognized as "foreign" by the immune system. However, cancer cells have found ways to evade detection by the immune system.

Scientists pinpoint gene to blame for poorer survival rate in early-onset breast cancer patients

December 15, 2017
A new study led by scientists at the University of Southampton has found that inherited variation in a particular gene may be to blame for the lower survival rate of patients diagnosed with early-onset breast cancer.

Scientists unlock structure of mTOR, a key cancer cell signaling protein

December 14, 2017
Researchers in the Sloan Kettering Institute have solved the structure of an important signaling molecule in cancer cells. They used a new technology called cryo-EM to visualize the structure in three dimensions. The detailed ...

'Bet hedging' explains the efficacy of many combination cancer therapies

December 14, 2017
The efficacy of many FDA-approved cancer drug combinations is not due to synergistic interactions between drugs, but rather to a form of "bet hedging," according to a new study published by Harvard Medical School researchers ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.