Teriparatide ups bone union for women with osteoporosis

November 3, 2012
Teriparatide ups bone union for women with osteoporosis
Injections of teriparatide are more effective than oral bisphosphonate for bone union after instrumented lumbar posterolateral fusion in women with postmenopausal osteoporosis, according to a study published in the Nov. 1 issue of Spine.

(HealthDay)—Injections of teriparatide are more effective than oral bisphosphonate for bone union after instrumented lumbar posterolateral fusion in women with postmenopausal osteoporosis, according to a study published in the Nov. 1 issue of Spine.

Seiji Ohtori, M.D., Ph.D., from Chiba University in Japan, and colleagues examined the clinical efficacy of teriparatide for bone union in 57 women with osteoporosis diagnosed with degenerative spondylolisthesis who underwent decompression and one- or two-level instrumented posterolateral fusion with a local . Patients were divided into a teriparatide treatment group (29 patients receiving daily subcutaneous injection of 20 µg teriparatide) or group (28 women receiving weekly oral administration of 17.5 mg of risedronate).

The researchers found that pain scores improved after surgery but that there were no significant between-group differences. In the teriparatide group, the rate of bone union was 82 percent, compared with 68 percent in the bisphosphonate group, and the average duration of bone union was eight and 10 months, respectively. Both the rate of bone union and average duration of bone union were significantly superior in the teriparatide group versus the bisphosphonate group.

"The teriparatide-treated patients showed superior results in the rate of bone union and average duration of bone union compared with the bisphosphonate-treated patients," the authors write. "We think that can enhance in patients with osteoporosis."

Explore further: Instrumented spinal fusion method impacts infection rate

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Instrumented spinal fusion method impacts infection rate

May 21, 2012
(HealthDay) -- For patients who undergo instrumented spinal fusion, the rates of infection are higher among those who receive posterior lumbar interbody fusion compared with those who receive posterior or posterolateral fusion, ...

Low vitamin D levels are related to decreased response to osteoporosis medicine

June 6, 2011
Women with low bone density are seven times more likely to benefit from a bisphosphonate drug when their vitamin D blood levels are above recent recommendations from the Institute of Medicine (IOM) as adequate for bone health. ...

Yearly zoledronic acid at lower-than-standard doses increases bone density

June 6, 2011
A lower dose of zoledronic acid than currently recommended for prevention of bone fractures due to osteoporosis decreases bone resorption and increases bone density, and may be effective in reducing the risk of osteoporotic ...

Recommended for you

Don't hold your nose and close your mouth when you sneeze, doctors warn

January 15, 2018
Pinching your nose while clamping your mouth shut to contain a forceful sneeze isn't a good idea, warn doctors in the journal BMJ Case Reports.

New antifungal provides hope in fight against superbugs

January 12, 2018
Microscopic yeast have been wreaking havoc in hospitals around the world—creeping into catheters, ventilator tubes, and IV lines—and causing deadly invasive infection. One culprit species, Candida auris, is resistant ...

Dengue takes low and slow approach to replication

January 11, 2018
A new study reveals how dengue virus manages to reproduce itself in an infected person without triggering the body's normal defenses. Duke researchers report that dengue pulls off this hoax by co-opting a specialized structure ...

Different strains of same bacteria trigger widely varying immune responses

January 11, 2018
Genetic differences between different strains of the same pathogenic bacterial species appear to result in widely varying immune system responses, according to new research published in PLOS Pathogens.

Human protein may aid neuron invasion by virus that causes hand, foot, and mouth disease

January 11, 2018
A human protein known as prohibitin may play a significant role in infection of the nervous system by EV71, one of several viruses that can cause hand, foot, and mouth disease. Issac Too of the National University of Singapore ...

Untangling how Epstein-Barr virus infects cells

January 11, 2018
A team led by scientists at Northwestern Medicine has discovered a new epithelial receptor for Epstein-Barr virus, according to a study published recently in Nature Microbiology.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.