Transplant effective in treating those with severe Crohn's disease, study shows

December 18, 2012

(Medical Xpress)—Patients suffering from severe Crohn's disease who were no longer able to tolerate intravenous feedings were able to return to a normal oral diet and saw no clinical recurrences of the disease after undergoing intestinal or multivisceral transplants, according to a study of cases performed at UPMC over more than 20 years.

The study is the largest of its kind examining the efficacy of transplant in patients with end-stage Crohn's disease. It was presented at the 2012 Advances in Inflammatory Bowel Diseases, the clinical and research conference of the Crohn's and Colitis Foundation, in Hollywood, Fla., on Dec. 15.

"Intestinal transplantation was developed here at UPMC, and, as in this specialized surgery, we have a wealth of data that other centers don't," said Guilherme Costa, M.D., interim director, UPMC Intestinal Rehabilitation and Transplantation Center, who presented the study. "What that data show us is that intestinal and multivisceral transplant works to save the lives of those patients suffering from the most severe symptoms of Crohn's disease."

Crohn's is a chronic bowel disease that can cause inflammation, ulcers and bleeding in the . Patients suffering from a severe form of the disease often have irreversible intestinal failure and sometimes need to receive nutrition through a tube inserted into a vein, known as total perenteral nutrition (TPN). Patients unable to tolerate TPN are often referred for an intestinal transplant.

In the study, UPMC researchers looked at 309 who received intestinal and multivisceral transplants between 1990 and June 2012. Of these, 57 had Crohn's disease with irreversible , and all had failed TPN therapy with multiple line infections. Twenty-one percent, or 12, of these patients also required a because they suffered from end-stage liver failure; 43 had just an intestinal transplant; and two patients had a modified multivisceral graft that included the stomach, duodenum, pancreas and intestine.

The study found the patient survival rate was 90 percent at one year, 74 percent at three years, 56 percent at five years, and 43 percent at 10 years. Inclusion of the donor liver was associated with better long-term survival outcome with a 10-year survival rate of 57 percent. All survivors achieved full nutritional autonomy, enjoying an unrestricted oral diet after transplant.

"The success we've seen in our patients is an indicator that offers real hope to Crohn's patients who have been debilitated by this disease," Dr. Costa said.

Explore further: Clinical trial seeks to cure advanced Crohn's disease using bone marrow transplant

Related Stories

Clinical trial seeks to cure advanced Crohn's disease using bone marrow transplant

July 23, 2012
Researchers at Fred Hutchinson Cancer Research Center have opened a clinical trial to test the theory that giving a patient a new immune system can cure severe cases of Crohn's disease, a chronic inflammatory condition of ...

Study finds potential new drug therapy for Crohn's disease

October 17, 2012
Ustekinumab, an antibody proven to treat the skin condition psoriasis, has now shown positive results in decreasing the debilitating effects of Crohn's Disease, according to researchers at the University of California San ...

Imaging technology might help doctors determine best treatment for Crohn's disease patients

October 14, 2011
It's difficult for doctors to tell whether a patient with Crohn's disease has intestinal fibrosis, which requires surgery, or inflammation, which can be treated with medicine. A new imaging method might make that task easier, ...

Specific bacterial species may initiate, maintain Crohn's

October 22, 2012
Patients newly diagnosed with pediatric Crohn's disease had significantly different levels of certain types of bacteria in their intestinal tracts than age-matched controls, according to a paper in the October Journal of ...

Recommended for you

A large-scale 'germ trap' solution for hospitals

July 26, 2017
When an infectious airborne illness strikes, some hospitals use negative pressure rooms to isolate and treat patients. These rooms use ventilation controls to keep germ-filled air contained rather than letting it circulate ...

Male hepatitis B patients suffer worse liver ailments, regardless of lifestyle

July 25, 2017
Why men with hepatitis B remain more than twice as likely to develop severe liver disease than women remains a mystery, even after a study led by a recent Drexel University graduate took lifestyle choices and environments ...

Researchers report new system to study chronic hepatitis B

July 25, 2017
Scientists from Princeton University's Department of Molecular Biology have successfully tested a cell-culture system that will allow researchers to perform laboratory-based studies of long-term hepatitis B virus (HBV) infections. ...

Mind-body therapies immediately reduce unmanageable pain in hospital patients

July 25, 2017
Mindfulness training and hypnotic suggestion significantly reduced acute pain experienced by hospital patients, according to a new study published in the Journal of General Internal Medicine.

Research examines lung cell turnover as risk factor and target for treatment of influenza pneumonia

July 24, 2017
Influenza is a recurring global health threat that, according to the World Health Organization, is responsible for as many as 500,000 deaths every year, most due to influenza pneumonia, or viral pneumonia. Infection with ...

Scientists propose novel therapy to lessen risk of obesity-linked disease

July 24, 2017
With obesity related illnesses a global pandemic, researchers propose in the Journal of Clinical Investigation using a blood thinner to target molecular drivers of chronic metabolic inflammation in people eating high-fat ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.