Accelerated cognitive decline seen with T2DM in middle age

January 21, 2013
Accelerated cognitive decline seen with T2DM in middle age
Middle-aged patients with type 2 diabetes show accelerated cognitive decline in information processing speed and executive function, according to a study published online Dec. 28 in Diabetes Care.

(HealthDay)—Middle-aged patients with type 2 diabetes show accelerated cognitive decline in information processing speed and executive function, according to a study published online Dec. 28 in Diabetes Care.

To examine the effects of baseline and incident diabetes on cognitive function, Peggy J.J. Spauwen, from Maastricht University in the Netherlands, and colleagues conducted cognitive testing on 1,290 individuals (40 years or older) participating in the Maastricht Aging Study. Testing was performed at baseline and at six and 12 years.

At baseline, 68 participants had type 2 diabetes, while 54 and 57 had incident diabetes at the six- and 12-year follow-up, respectively. Over the 12-year follow-up, the researchers identified significantly larger decline in information-processing speed, executive function, and delayed word recall among those with diabetes at baseline, compared with control subjects. There was no significant difference noted in the decline for immediate word recall. Participants with incident diabetes showed subtle early decrease in information-processing speed only, compared to the controls; however, in other cognitive domains there was no larger decline observed.

"It seems that disease-exposure time plays an important role in the development of . This might provide a window of opportunity for prevention and early treatment of diabetes-related cognitive deficits," the authors write. "For this, it is important to assess at an early stage of the disease and on a regular basis."

Explore further: Diabetes, poor glucose control associated with greater cognitive decline in older adults

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Diabetes, poor glucose control associated with greater cognitive decline in older adults

June 18, 2012
Among well-functioning older adults without dementia, diabetes mellitus (DM) and poor glucose control among those with DM are associated with worse cognitive function and greater cognitive decline, according to a report published ...

Irregular heartbeat strong predictor of decline in people at risk of heart disease

February 27, 2012
An irregular heartbeat -- atrial fibrillation -- is a strong predictor of cognitive decline and the loss of independence in daily activities in older people at risk of cardiovascular disease, according to a study in CMAJ ...

Mindfulness-based cognitive therapy beneficial in diabetes

December 11, 2012
(HealthDay)—For patients with diabetes and low levels of emotional well-being, mindfulness-based cognitive therapy (MBCT) improves emotional distress and health-related quality of life, according to a study published online ...

Recommended for you

Genetic discovery may help better identify children at risk for type 1 diabetes

January 17, 2018
Six novel chromosomal regions identified by scientists leading a large, prospective study of children at risk for type 1 diabetes will enable the discovery of more genes that cause the disease and more targets for treating ...

Thirty-year study shows women who breastfeed for six months or more reduce their diabetes risk

January 16, 2018
In a long-term national study, breastfeeding for six months or longer cuts the risk of developing type 2 diabetes nearly in half for women throughout their childbearing years, according to new Kaiser Permanente research published ...

Women who have gestational diabetes in pregnancy are at higher risk of future health issues

January 16, 2018
Women who have gestational diabetes mellitus (GDM) during pregnancy have a higher than usual risk of developing type 2 diabetes, hypertension, and ischemic heart disease in the future, according to new research led by the ...

Diabetes gene found that causes low and high blood sugar levels in the same family

January 15, 2018
A study of families with rare blood sugar conditions has revealed a new gene thought to be critical in the regulation of insulin, the key hormone in diabetes.

Discovery could lead to new therapies for diabetics

January 12, 2018
New research by MDI Biological Laboratory scientist Sandra Rieger, Ph.D., and her team has demonstrated that an enzyme she had previously identified as playing a role in peripheral neuropathy induced by cancer chemotherapy ...

Enzyme shown to regulate inflammation and metabolism in fat tissue

January 11, 2018
The human body has two primary kinds of fat—white fat, which stores excess calories and is associated with obesity, and brown fat, which burns calories in order to produce heat and has garnered interest as a potential means ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.