Creatinine excretion rate linked to higher mortality in T2DM

February 12, 2013
Creatinine excretion rate linked to higher mortality in T2DM
In patients with type 2 diabetes and nephropathy, a lower creatinine excretion rate is associated with higher all-cause mortality, according to research published online Jan. 8 in Diabetes Care.

(HealthDay)—In patients with type 2 diabetes and nephropathy, a lower creatinine excretion rate (CER) is associated with higher all-cause mortality, according to research published online Jan. 8 in Diabetes Care.

In an effort to examine whether CER is associated with outcome in diabetes, Steef J. Sinkeler, M.D., of the University of Groningen in the Netherlands, and colleagues used data from two trials involving 1,872 patients with and nephropathy and 24-hour urinary creatinine excretion data.

After a median follow-up period of 36 months, the researchers note that 300 patients had died. Factors that were positively and independently associated with CER were body surface area, hemoglobin, black race, and , while female gender and age were inverse independent determinants of CER. The risk of all-cause mortality increased as CER decreased in a Kaplan-Meier analysis of sex-stratified tertiles of the CER. In multivariate analysis, lower CER correlated independently with an elevated risk of all-cause mortality (hazard ratio, 0.39). These results were similar after adjustment for potential collection errors.

"In conclusion, the CER, which serves as a surrogate marker for muscle mass, was inversely associated with all-cause mortality in diabetic patients with nephropathy, thus indicating that the CER can be used as a risk marker in this population," the authors write. "It would be of interest to see whether halting the loss of muscle mass seen in diabetes by physical activity may improve outcomes."

The trials were sponsored by Merck, , and Sanofi-Aventis. One author disclosed financial ties to Merck.

Explore further: ASMBS: bariatric surgery helps resolve diabetic nephropathy

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

ASMBS: bariatric surgery helps resolve diabetic nephropathy

June 20, 2012
(HealthDay) -- For patients with diabetes who undergo bariatric surgery there is a significant long-term improvement in diabetic nephropathy, according to a study presented at the annual meeting of the American Society for ...

Low HDL cholesterol ups risk of diabetic nephropathy

August 22, 2012
(HealthDay) -- High-density lipoprotein cholesterol (HDL-C) is an independent risk factor for the development of diabetic nephropathy, but not retinopathy, in patients with type 2 diabetes, according to research published ...

Combo of diabetes, depression increases post-MI mortality

February 27, 2012
(HealthDay) -- Having both diabetes and depression significantly increases the risk of dying in the years following a heart attack, beyond the increased risk from either condition alone, according to a study published in ...

Recommended for you

Women who have gestational diabetes in pregnancy are at higher risk of future health issues

January 16, 2018
Women who have gestational diabetes mellitus (GDM) during pregnancy have a higher than usual risk of developing type 2 diabetes, hypertension, and ischemic heart disease in the future, according to new research led by the ...

Diabetes gene found that causes low and high blood sugar levels in the same family

January 15, 2018
A study of families with rare blood sugar conditions has revealed a new gene thought to be critical in the regulation of insulin, the key hormone in diabetes.

Discovery could lead to new therapies for diabetics

January 12, 2018
New research by MDI Biological Laboratory scientist Sandra Rieger, Ph.D., and her team has demonstrated that an enzyme she had previously identified as playing a role in peripheral neuropathy induced by cancer chemotherapy ...

Enzyme shown to regulate inflammation and metabolism in fat tissue

January 11, 2018
The human body has two primary kinds of fat—white fat, which stores excess calories and is associated with obesity, and brown fat, which burns calories in order to produce heat and has garnered interest as a potential means ...

Big strides made in diabetes care

January 5, 2018
(HealthDay)—This past year was a busy, productive one for diabetes research and care.

Gene therapy restores normal blood glucose levels in mice with type 1 diabetes

January 4, 2018
Type 1 diabetes is a chronic disease in which the immune system attacks and destroys insulin-producing beta cells in the pancreas, resulting in high blood levels of glucose. A study published January 4th in Cell Stem Cell ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.