n-3 PUFA may reduce markers of kidney disease in T2DM

February 8, 2013
n-3 PUFA may reduce markers of kidney disease in T2DM
In patients with type 2 diabetes and evidence of kidney injury, supplementation with n-3 long-chain polyunsaturated fatty acids does not reduce urine albumin excretion but is associated with a reduction in certain markers of kidney injury, according to research published online Dec. 28 in Diabetes Care.

(HealthDay)—In patients with type 2 diabetes and evidence of kidney injury, supplementation with n-3 long-chain polyunsaturated fatty acids (PUFA) does not reduce urine albumin excretion but is associated with a reduction in certain markers of kidney injury, according to research published online Dec. 28 in Diabetes Care.

To examine the effect of n-3 PUFA supplementation on urine albumin excretion and markers of kidney injury, Edgar R. Miller III, M.D., Ph.D., of the Johns Hopkins School of Medicine in Baltimore, and colleagues conducted a randomized, placebo-controlled, two-period crossover trial involving 29 participants with type 2 diabetes and evidence of kidney disease who were given 4 g/day of n-3 PUFA supplements for six weeks.

The researchers found that n-3 PUFA supplementation resulted in non-significant reductions in urine albumin excretion compared with placebo, and correlated with significant reductions in urine neutrophil gelatinase-associated lipocalin (NGAL) excretion. There was no significant effect for n-3 PUFA on of or estimated . In the subgroup of participants taking medications that block the renin-angiotensin-aldosterone system, significant decreases were observed in 24-hour urinary albumin excretion, NGAL, liver fatty acid-binding protein, and N-acetyl β-D-glucosaminidase.

"n-3 PUFA failed to reduce the primary outcome of urine albumin excretion," the authors write. "However, there was a consistent trend of benefit for all urine biomarkers and a significant reduction in NGAL."

Lovaza (n-3 PUFA) and placebo used in the study were provided by GlaxoSmithKline.

Explore further: Fatty acids don't reduce atrial fibrillation recurrence

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Fatty acids don't reduce atrial fibrillation recurrence

December 21, 2012
(HealthDay)—Polyunsaturated fatty acids (n-3 PUFA) do not reduce the recurrence of atrial fibrillation (AF), according to a study published online Dec. 19 in the Journal of the American College of Cardiology.

Urinary protein excretion—even in the normal range—raises diabetics' heart risks

August 30, 2012
In individuals with type 2 diabetes, any degree of measurable urinary protein excretion—even in what is considered the normal range—increases their risk of experiencing heart problems, according to a study appearing in ...

Warning signs predict kidney injury after surgery

August 12, 2011
Acute kidney injury (AKI) is a common – but preventable -- complication after surgery that can lead to other complications or even death. The use and development of biomarkers will help physicians diagnose and treat ...

Recommended for you

Scientists discover a new way to treat type 2 diabetes

July 21, 2017
Medication currently being used to treat obesity is also proving to have significant health benefits for patients with type 2 diabetes. A new study published today in Molecular Metabolism explains how this therapeutic benefit ...

Alzheimer's drug cuts hallmark inflammation related to metabolic syndrome by 25 percent

July 20, 2017
An existing Alzheimer's medication slashes inflammation and insulin resistance in patients with metabolic syndrome, a potential therapeutic intervention for a highly dangerous condition affecting 30 percent of adults in the ...

Diabetes or its precursor affects 100 million Americans

July 19, 2017
Almost one-third of the US population—100 million people—either has diabetes or its precursor condition, known as pre-diabetes, said a government report Tuesday.

One virus may protect against type 1 diabetes, others may increase risk

July 11, 2017
Doctors can't predict who will develop type 1 diabetes, a chronic autoimmune disease in which the immune system destroys the cells needed to control blood-sugar levels, requiring daily insulin injections and continual monitoring.

Diabetes complications are a risk factor for repeat hospitalizations, study shows

July 7, 2017
For patients with diabetes, one reason for hospitalization and unplanned hospital readmission is severe dysglycemia (uncontrolled hyperglycemia - high blood sugar, or hypoglycemia - low blood sugar), says new research published ...

Researchers identify promising target to protect bone in patients with diabetes

July 7, 2017
Utilizing metabolomics research techniques, NYU Dentistry researchers investigated the underlying biochemical activity and signaling within the bone marrow of hyperglycemic mice with hopes of reducing fracture risks of diabetics

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.