Latest research shows two items are key to decrease symptoms and prolong survival for LMC patients

April 22, 2013, International Association for the Study of Lung Cancer

Lung cancer is one of the most common primary cancers that cause leptomeningeal carcinomatosis (LMC), when cancer spreads to the membranes surrounding the spinal cord and brain. Cases of LMC have increased because of the improved survival of lung cancer patients with the help of new advances in treatment. This is the type of cancer diagnosis facingValerie Harper, who played Rhonda on "The Mary Tyler Moore Show."

Now research published in the International Association for the Study of Lung Cancer's Journal of Thoracic Oncology (JTO) shows the effectiveness of intraventricular chemotherapy (chemotherapy injected directly into the ventricles of the brain) in terms of symptom response rate and overall survival in patients with LMC from non-small cell lung cancer (NSCLC).

Researchers from the National Cancer Center in Goyang, Korea did a on 105 patients with NSCLC who had undergone intraventricular chemotherapy. They conclude that intraventricular chemotherapy for patients with LMC from NSCLC could palliate associated symptoms and prolong patients' survival.

"Among the 54 patients with increased ICP at the entry of the treatment," the study says, "20 patients achieved normal ICP (< 15 cm H2O) after the intraventricular chemotherapy, excluding three patients who underwent a ventriculo-peritoneal shunt. However, 15 of 51 patients with normal ICP at the start of treatment showed increased ICP during the course of the therapy and remained uncontrolled. Thus, the total increased ICP control rate of intraventricular therapy was 20 of 69 (29 percent)."

As a result, the researchers conclude that, "Careful selection of patients for intraventricular chemotherapy is recommended, with aggressive ICP control, and concurrent systemic chemotherapy."

Explore further: EURTAC Phase III study: Erlotinib nearly doubles progression-free survival vs. chemotherapy

Related Stories

EURTAC Phase III study: Erlotinib nearly doubles progression-free survival vs. chemotherapy

July 5, 2011
In the first phase III study to include Western lung cancer patients, first-line treatment with erlotinib (Tarceva) nearly doubled progression-free survival compared with chemotherapy, according to research presented at the ...

High EGFR expression a predictor for improved survival with cetuximab plus chemotherapy

July 5, 2011
High epidermal growth factor receptor (EGFR) expression was a good predictor of which lung cancer patients would survive longer when cetuximab (Erbitux) was added to first-line chemotherapy, according to research presented ...

Brain radiation after lung cancer treatment reduces risk of cancer spreading

September 6, 2012
Stage III non-small cell lung cancer (NSCLC) patients treated with surgery and/or radiation therapy have a significantly reduced risk of developing brain metastases if they also receive prophylactic cranial irradiation (PCI); ...

Chemotherapy effective for patients with resected SCLC or large-cell neuroendocrine carcinoma

June 15, 2012
Research presented in the July 2012 issue of the International Association for the Study of Lung Cancer's (IASLC) Journal of Thoracic Oncology, concluded that patients with limited large cell neuroendocrine tumors or with ...

Recommended for you

Single blood test screens for eight cancer types

January 18, 2018
Johns Hopkins Kimmel Cancer Center researchers developed a single blood test that screens for eight common cancer types and helps identify the location of the cancer.

Researchers find a way to 'starve' cancer

January 18, 2018
Researchers at Vanderbilt University Medical Center (VUMC) have demonstrated for the first time that it is possible to starve a tumor and stop its growth with a newly discovered small compound that blocks uptake of the vital ...

How cancer metastasis happens: Researchers reveal a key mechanism

January 18, 2018
Cancer metastasis, the migration of cells from a primary tumor to form distant tumors in the body, can be triggered by a chronic leakage of DNA within tumor cells, according to a team led by Weill Cornell Medicine and Memorial ...

Modular gene enhancer promotes leukemia and regulates effectiveness of chemotherapy

January 18, 2018
Every day, billions of new blood cells are generated in the bone marrow. The gene Myc is known to play an important role in this process, and is also known to play a role in cancer. Scientists from the German Cancer Research ...

These foods may up your odds for colon cancer

January 18, 2018
(HealthDay)—Chowing down on red meat, white bread and sugar-laden drinks might increase your long-term risk of colon cancer, a new study suggests.

The pill lowers ovarian cancer risk, even for smokers

January 18, 2018
(HealthDay)—It's known that use of the birth control pill is tied to lower odds for ovarian cancer, but new research shows the benefit extends to smokers or women who are obese.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.