New method improves ability to continuously measure glucose in diabetic patients

May 8, 2013, Asociacion RUVID

Researchers at the Universitat Politècnica de València and the Universitat de Girona have developed a new method for continuous glucose monitoring in patients with type 1 diabetes. It is based on a new calibration algorithm which is adapted to existing treatment devices and increases the accuracy in estimating blood glucose and helps regulate a controlled and automatic insulin release. The system has been patented by the two Spanish universities.

"Our method is a step towards the development of an "" for an automatic and helps improve the quality of life of patients with ," says Valencian researcher Jorge Bondia.

Currently, explains Jorge Bondia, the patient is subjected to intensive insulin therapy, either by multiple daily injections or continuous infusion using . However, intensive insulin therapy increases the episodes of hypoglycemia, which can have serious consequences such as diabetic coma. Thus, blood glucose monitoring is an essential element in the treatment and control of diabetic patients.

This type of monitoring is based on the measurement of glucose concentration in interstitial fluid. "To carry out these studies, calibration algorithms are fundamental for the correct estimation of blood glucose. Current algorithms are based on linear regression techniques where the dynamic information between different biological compartments is ignored and this may cause high estimation errors. It is precisely the magnitude of the error that caused the continuous glucose monitoring to be considered today as a tool to complement and not replace capillary measurement," adds Jorge Bondia.

The method developed by the Spanish labs reduces these estimation errors. It consists of an algorithm based on a set of trained estimators using data from a representative population of patients. "Our goal with this project is to help continuous glucose monitoring to cease to be complementary to capillary measurement," says the researcher. The team has validated this new technology in clinical studies.

Explore further: Dual-hormone artificial pancreas is a step closer for patients with Type 1 diabetes

More information: Rico, B. et al. Adaptive calibration algorithm for plasma glucose estimation in continuous glucose monitoring. Biomedical and Health Informatics. DOI: 10.1109/JBHI.2013.2253325

Related Stories

Dual-hormone artificial pancreas is a step closer for patients with Type 1 diabetes

January 28, 2013
For patients with type 1 diabetes, a dual-hormone artificial pancreas system (also known as a closed-loop delivery system) improved the control of glucose levels and reduced the risk of hypoglycemia compared with conventional ...

Experts find continuous glucose monitoring beneficial in maintaining target blood glucose levels

October 11, 2011
Patients with diabetes face daily challenges in managing their blood glucose levels, and it has been postulated that patients could benefit from a system providing continuous real-time glucose readings. Today, The Endocrine ...

Automatic suspension of insulin delivery via insulin pumps reduces hypoglycemia

February 9, 2012
An automated on/off feature built into insulin pump systems can suspend insulin delivery when it detects low blood glucose levels (via continuous glucose monitoring), significantly reducing the severity and duration of hypoglycemia ...

Recommended for you

Physical exercise reduces risk of developing diabetes: study

February 20, 2018
Exercising more reduces the risk of diabetes and could see seven million fewer diabetic patients across mainland China, Hong Kong and Taiwan, according to new research.

Researchers find existing drug effective at preventing onset of type 1 diabetes

February 15, 2018
A drug commonly used to control high blood pressure may also help prevent the onset of type 1 diabetes in up to 60 percent of those at risk for the disease, according to researchers at the University of Colorado Anschutz ...

Chemist designs diabetic treatment minus harmful side effects

February 9, 2018
A chemist in the College of Arts and Sciences (A&S) has figured out how to control glucose levels in the bloodstream without the usual side effects of nausea, vomiting or malaise.

Peptide improves glucose and insulin sensitivity, lowers weight in mice

February 8, 2018
Treating obese mice with catestatin (CST), a peptide naturally occurring in the body, showed significant improvement in glucose and insulin tolerance and reduced body weight, report University of California San Diego School ...

Study reports use of nutritional ketosis with mobile app intervention could reverse Type 2 diabetes

February 7, 2018
A newly published study has shown that an individualized approach to nutritional ketosis (utilizing fat rather than glucose to fuel the body), combined with remote monitoring via a mobile application, could sustainably and ...

Simple molecule could prevent, alleviate pre-diabetes

February 7, 2018
Restoring levels of coenzyme Q10 (CoQ), a key molecule in energy production in cells, could overcome insulin resistance or pre-diabetes—a precursor to type 2 diabetes and cardiovascular disease.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.