In mild strokes, ultra-early treatment may eliminate risk of disability

August 22, 2013, American Heart Association

In the case of mild or moderate strokes, getting treatment ultra-fast – within 90 minutes of experiencing symptoms – greatly reduces the risk of suffering disability, according to a new study reported in the American Heart Association's journal Stoke.

The American Heart Association/American Stroke Association recommends getting to a hospital within three hours of the onset of . According to guidelines, clot-busting drugs may be given to treat stroke up to 4.5 hours after the onset of symptoms.

The study found that survivors with mild to moderate strokes who were given the clot-busting drugs in the first 90 minutes of the recommended had little or no disability three months later compared to those who were treated between 90 and 270 minutes.

"Ultra-early treatment increases the likelihood of excellent outcome in patients with moderately severe symptoms, and in secondary analysis also in those with mild symptoms," said Daniel Strbian, M.D., Ph.D., from the Department of Neurology at Helsinki University Central Hospital in Helsinki, Finland. "All measures must be taken to reduce onset-to-treatment time as much as possible."

The study included more than 6,800 at 10 in Europe over 14 years. They were treated intravenously with Alteplase, a clot-busting drug that is given through an IV in the vein. Patients were separated into three groups based on stroke severity – minor (NIH stroke score 0-6), mild/moderate (NIH score 7-12), or moderate/severe (NIH score higher than 12). Those with mild to moderate stroke seemed to benefit most from the ultra-early care. Early treatment also helped those with minor strokes, but the likelihood of disability is already very low in these patients.

Those with severe stroke did not benefit as much from the ultra-early treatment because they had severe .

"We need more research to offer something more for people with severe strokes," Strbian said.

Explore further: Delay in seeking stroke care costs women best treatment

Related Stories

Delay in seeking stroke care costs women best treatment

July 25, 2013
Women with clot-caused strokes are less likely than men to arrive at the hospital in time to receive the best treatment, according to a European study reported in the American Heart Association journal Stroke.

Your eyes may hold clues to stroke risk

August 12, 2013
Your eyes may be a window to your stroke risk. In a study reported in the American Heart Association journal Hypertension, researchers said retinal imaging may someday help assess if you're more likely to develop a stroke—the ...

'Mini' stroke can cause major disability, may warrant clot-busters

September 13, 2012
A transient ischemic attack, TIA or a "mini stroke," can lead to serious disability, but is frequently deemed by doctors too mild to treat, according to a study in the American Heart Association journal Stroke.

Certified stroke centers more likely to give clot-busting drugs

March 26, 2013
Stroke patients are three times more likely to receive clot-busting medication if treated at a certified stroke center, according to a study in the Journal of the American Heart Association.

Adding endovascular therapy to tPA didn't improve recovery after stroke

February 8, 2013
Adding endovascular therapy to clot-busting therapy for stroke did not significantly improve stroke recovery at three months, according to a study presented in a special symposium at the American Stroke Association's International ...

Clot-busting drugs appear safe for treating 'wake-up' stroke patients

February 1, 2012
Clot-busting drugs may be safe for patients who wake up experiencing stroke symptoms, according to preliminary research presented at the American Stroke Association's International Stroke Conference 2012.

Recommended for you

A nanoparticle inhalant for treating heart disease

January 18, 2018
A team of researchers from Italy and Germany has developed a nanoparticle inhalant for treating people suffering from heart disease. In their paper published in the journal Science Translational Medicine, the group describes ...

Starting periods before age of 12 linked to heightened risk of heart disease and stroke

January 15, 2018
Starting periods early—before the age of 12—is linked to a heightened risk of heart disease and stroke in later life, suggests an analysis of data from the UK Biobank study, published online in the journal Heart.

'Decorated' stem cells could offer targeted heart repair

January 10, 2018
Although cardiac stem cell therapy is a promising treatment for heart attack patients, directing the cells to the site of an injury - and getting them to stay there - remains challenging. In a new pilot study using an animal ...

Two simple tests could help to pinpoint cause of stroke

January 10, 2018
Detecting the cause of the deadliest form of stroke could be improved by a simple blood test added alongside a routine brain scan, research suggests.

Exercise is good for the heart, high blood pressure is bad—researchers find out why

January 10, 2018
When the heart is put under stress during exercise, it is considered healthy. Yet stress due to high blood pressure is bad for the heart. Why? And is this always the case? Researchers of the German Centre for Cardiovascular ...

Heart-muscle patches made with human cells improve heart attack recovery

January 10, 2018
Large, human cardiac-muscle patches created in the lab have been tested, for the first time, on large animals in a heart attack model. This clinically relevant approach showed that the patches significantly improved recovery ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.