Harvest toolkit offers innovative data discovery resource for biomedical researchers

October 17, 2013
Harvest users can query sets of data such as blood test results to easily display results by a variety of criteria, e.g., to create subgroups by gender or by those within a specific range of platelet counts or leukocyte counts. Credit: The Children's Hospital of Philadelphia

Biomedical researchers often confront large quantities of information that may be amassed in many forms: vital signs, blood cell counts, lengthy DNA sequences, bar graphs, MRIs, patient demographics, and so much more. How do researchers assemble, access and analyze all that data without having to become specialized database technicians themselves?

A team of informatics experts and at The Children's Hospital of Philadelphia (CHOP) offers a new software toolkit to help researchers wrangle . Their open-source, highly interactive framework called Harvest is designed to let users to navigate quickly among different types and levels of data.

"We want to help researchers explore their data, not their database," said Byron Ruth, lead developer of Harvest at CHOP's Center for Biomedical Informatics (CBMi). Ruth is one of the co-authors of a paper introducing CBMi's Harvest framework, appearing online Oct. 16 in the Journal of the American Medical Informatics Association.

Co-author Michael J. Italia added, "Research institutions typically work through their information technology staff to provide a single data warehouse that may be too general-purpose for all its projects, or develop one-off solutions on a case-by-case basis for each project."

"Our approach in Harvest is different," said Italia, the CBMi's manager of Applications Research. "We decided to focus on end-users, generalizing the toolkit for application to any biomedical study with multiple collaborators, but also allowing individual software developers and data managers to customize the software for specific projects."

Harvest, said Italia, "isn't just shrink-wrapped, ready-to-go software." He estimates that Harvest typically provides 80 percent of the work, leaving it to any institution's to adapt the framework to a project's needs, in collaboration with each project's principal investigator. Harvest is open-source, so users are free to see bug reports, check software patches, and share fixes and customizations with a wider community of users.

A key feature of Harvest is the ability to maneuver smoothly among various levels of data, from individual patient records to aggregated reports of all patients in a database, and to subpopulations in between. Users can construct queries to slice and dice data—grouping subjects, for instance, by age or ethnicity, calling up individual blood test results or MRIs, or including or excluding specific diagnoses.

One advantage of Harvest is that it provides transparency and visibility to data in a manner that is familiar to a researcher who is invested in a particular disease or project. "Harvest adopts convenient and clear interfaces to view and explore data that are increasingly used in other industries, such as social media," said senior author and CBMi director Peter S. White, Ph.D. "We have found that this often helps users to quickly familiarize themselves with data they are seeing, which increases the likelihood that they will trust the resource, and even be incentivized to contribute to the project as it develops."

The Harvest developers say their tool reflects the growing complexity of research in the Big Data era of and genomic technology. In the 1980s and 1990s, much federal research followed a hypothesis-driven model, focusing on predefined measurements within a patient population. Many current databases collect vast amounts of many data types with fewer preconceived notions of what is significant. "Harvest allows users to formulate and refine questions and even explore a different view of data that wasn't apparent or important to them a few minutes before," said Italia.

The CBMi team originally designed Harvest to manage data from AudGenDB, an audiology database funded by the National Institute on Deafness and Other Communications Disorders.

In the current paper, the study team evaluated Harvest by running it through its paces with data from two other collections: CardioDB, which stores clinical data from 47,000 of CHOP's pediatric cardiology patients, and OpenMRS, a public dataset holding lab results, infection status and other clinical results from electronic health records.

CBMi is now applying Harvest to more collections, including the Longitudinal Pediatric Data Resource, a long-term informatics system being created to store clinical data derived from thousands of children with conditions detected in national newborn screening programs. "Although these collections contain very different types of data, the Harvest toolkit is flexible enough to adapt to these different scenarios, while at the same time maintaining a consistent set of basic components," added Ruth.

Harvest has been focused primarily on the end-user up to this point. Future work includes a bigger focus on software developers and applications support personnel who are responsible for setting up and maintaining Harvest applications. "However, as we think about the life cycle of a Harvest application, we want it to be as easy as possible for administrators and developers to get Harvest into the hands of researchers," Italia said.

Explore further: Early-warning system to prevent fishery collapse discovered

More information: "Harvest: An Open Platform for Developing Web-Based Biomedical Data Discovery and Reporting Applications," Journal of the American Medical Informatics Association, published online Oct. 16, 2013. jamia.bmj.com/content/early/20 … /amiajnl-2013-001825

Related Stories

Early-warning system to prevent fishery collapse discovered

September 16, 2013
Threats from overfishing can be detected early enough to save fisheries— and livelihoods —with minimal adjustments in harvesting practices, a new study by researchers in the University of Minnesota's College of Biological ...

Recommended for you

Post-stroke patients reach terra firma with new exosuit technology

July 26, 2017
Upright walking on two legs is a defining trait in humans, enabling them to move very efficiently throughout their environment. This can all change in the blink of an eye when a stroke occurs. In about 80% of patients post-stroke, ...

Molecular hitchhiker on human protein signals tumors to self-destruct

July 24, 2017
Powerful molecules can hitch rides on a plentiful human protein and signal tumors to self-destruct, a team of Vanderbilt University engineers found.

Researchers develop new method to generate human antibodies

July 24, 2017
An international team of scientists has developed a method to rapidly produce specific human antibodies in the laboratory. The technique, which will be described in a paper to be published July 24 in The Journal of Experimental ...

New vaccine production could improve flu shot accuracy

July 24, 2017
A new way of producing the seasonal flu vaccine could speed up the process and provide better protection against infection.

A sodium surprise: Engineers find unexpected result during cardiac research

July 20, 2017
Irregular heartbeat—or arrhythmia—can have sudden and often fatal consequences. A biomedical engineering team at Washington University in St. Louis examining molecular behavior in cardiac tissue recently made a surprising ...

Want to win at sports? Take a cue from these mighty mice

July 20, 2017
As student athletes hit training fields this summer to gain the competitive edge, a new study shows how the experiences of a tiny mouse can put them on the path to winning.


Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.