Gabapentin doesn't cut use of morphine post-knee arthroplasty

Gabapentin doesn't cut use of morphine post-knee arthroplasty
(HealthDay)—The addition of gabapentin to patient-controlled analgesia (PCA) protocol does not reduce morphine consumption, pain, or opioid-related side effects in patients undergoing total knee arthroplasty, according to a study published in the Nov. 20 issue of The Journal of Bone & Joint Surgery.

In an effort to examine whether gabapentin reduces morphine consumption, James E. Paul, M.D., from McMaster University in Hamilton, Canada, and colleagues conducted a randomized trial involving 101 patients (mean age, 63 years; 63 percent women) who were receiving total knee arthroplasty. All participants received acetaminophen and intravenous ketorolac two hours before surgery, and after surgery they received PCA morphine for three days, and acetaminophen and ketorolac. In addition, participants were randomized to receive pre- and postoperative gabapentin (52 patients) or placebo (49 patients).

The researchers found that there was no between-group difference in cumulative morphine consumption at 72 hours (66.3 mg in the gabapentin group versus 72.5 mg the placebo group). There was also no difference between the groups in scores at rest, with movement, or with weight bearing. In both groups, the incidence of nausea, vomiting, pruritus, dizziness or light-headedness, and visual disturbances was similar. The groups did not differ in the knee range-of-motion at discharge.

"In patients having , the addition of to the PCA did not reduce morphine consumption, pain, or opioid-related side effects," the authors write.


Explore further

Multimodal analgesia lessens post-op morphine needs

More information: Abstract
Full Text (subscription or payment may be required)

Copyright © 2013 HealthDay. All rights reserved.

Citation: Gabapentin doesn't cut use of morphine post-knee arthroplasty (2013, November 27) retrieved 25 June 2019 from https://medicalxpress.com/news/2013-11-gabapentin-doesnt-morphine-post-knee-arthroplasty.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
 shares

Feedback to editors

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more