Nerve root sedimentation sign for spinal stenosis assessed

December 8, 2013
Nerve root sedimentation sign for spinal stenosis assessed

(HealthDay)—The nerve root sedimentation sign (SedSign), seen on magnetic resonance images, can differentiate lumbar spinal stenosis (LSS) from asymptomatic controls, according to a study published in the Nov. 15 issue of Spine.

Christy C. Tomkins-Lane, Ph.D., from Mount Royal University in Calgary, Canada, and colleagues examined the sensitivity and specificity of the SedSign in a retrospective study involving three blinded raters who independently reviewed from 67 subjects with clinically diagnosed LSS confirmed on imaging by a spine specialist; 31 people with low back pain (LBP) but no LSS; four people with severe vascular claudication; and 46 asymptomatic participants.

The researchers found that inter-rater reliability ranged from 0.62 to 0.69 and intrarater reliability for the sign ranged from κ = 0.87 to 0.97. Sensitivity and specificity ranged from 42 to 66 percent and 49 to 78 percent, respectively. Inclusion of images with only a smallest cross-sectional area of the dural sac <80 mm² improved sensitivity to a range of 60 to 96 percent. SedSign could differentiate between LSS and asymptomatic controls (P = 0.004) but was not able to differentiate between LSS and LBP or between LSS and vascular claudication.

"The sign seems most sensitive in defining severe LSS cases and yet may not add any specific diagnostic information beyond the traditional history, physical examination and imaging studies that are standard in LSS diagnosis," the authors write.

Relevant financial activities outside the submitted work included expert testimony and payment for lectures.

Explore further: Diabetes, hypertension prevalent with spinal stenosis

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Diabetes, hypertension prevalent with spinal stenosis

May 7, 2013
(HealthDay)—Nonelderly, older adults with lumbar spinal stenosis (LSS) have a higher prevalence of diabetes and hypertension than those without stenosis, according to a study published in the April 20 issue of Spine.

Fusion rate up for lumbar spinal stenosis, 2004 to 2009

June 13, 2013
(HealthDay)—For patients hospitalized for lumbar spinal stenosis (LSS), the rate of fusions significantly increased and the rate of decompressions significantly decreased from 2004 to 2009 in the United States, according ...

Lumbar spinal stenosis lowers health-related QoL

April 7, 2012
(HealthDay) -- Patients diagnosed with lumbar spinal stenosis (LSS) have a substantial burden of illness and reduced health-related quality of life (HRQL) compared to the general population, and their HRQL is compounded by ...

EP studies helpful in lumbar spinal stenosis prognosis

December 28, 2012
(HealthDay)—Electrophysiological abnormalities have been identified that are of some prognostic value in determining deteriorating clinical status over the long term for patients with mild-to-moderate lumbar spinal stenosis ...

Pain, disability don't predict function in spinal stenosis

July 16, 2012
(HealthDay) -- For patients with lumbar spinal stenosis (LSS), subjective measures of pain and disability have limited ability to predict real-life ambulatory performance, according to a study published in the July 1 issue ...

Lifestyle activities impact development of spinal stenosis

May 16, 2013
(HealthDay)—Increased loading of the lumbar spine, arising from lifestyle activities (such as lifting heavy objects, more frequent pregnancy, and higher body mass index), could contribute to the degenerative process and ...

Recommended for you

Don't hold your nose and close your mouth when you sneeze, doctors warn

January 15, 2018
Pinching your nose while clamping your mouth shut to contain a forceful sneeze isn't a good idea, warn doctors in the journal BMJ Case Reports.

New antifungal provides hope in fight against superbugs

January 12, 2018
Microscopic yeast have been wreaking havoc in hospitals around the world—creeping into catheters, ventilator tubes, and IV lines—and causing deadly invasive infection. One culprit species, Candida auris, is resistant ...

Dengue takes low and slow approach to replication

January 11, 2018
A new study reveals how dengue virus manages to reproduce itself in an infected person without triggering the body's normal defenses. Duke researchers report that dengue pulls off this hoax by co-opting a specialized structure ...

Different strains of same bacteria trigger widely varying immune responses

January 11, 2018
Genetic differences between different strains of the same pathogenic bacterial species appear to result in widely varying immune system responses, according to new research published in PLOS Pathogens.

Human protein may aid neuron invasion by virus that causes hand, foot, and mouth disease

January 11, 2018
A human protein known as prohibitin may play a significant role in infection of the nervous system by EV71, one of several viruses that can cause hand, foot, and mouth disease. Issac Too of the National University of Singapore ...

Untangling how Epstein-Barr virus infects cells

January 11, 2018
A team led by scientists at Northwestern Medicine has discovered a new epithelial receptor for Epstein-Barr virus, according to a study published recently in Nature Microbiology.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.