Disease severity factors ID'd for human rhinovirus

Disease severity factors ID'd for human rhinovirus

(HealthDay)—Human rhinovirus (HRV) infection is a common pathogen seen in young children with respiratory infection symptoms, with severe disease caused mainly by presence of respiratory syncytial virus (RSV) in coinfections, prematurity, congenital heart disease, and noninfectious respiratory disease, according to a study published online Jan. 13 in Pediatrics.

Lourenço Faria Costa, Ph.D., from the Instituto de Ciências Biomédicas in Uberlvândia, Brazil, and colleagues retrospectively evaluated HRV infection using nasopharyngeal aspirates from 434 children aged up to 5 years. The children presented with a broad range of respiratory infection symptoms. The authors assessed the presence of HRV and eight other , as well as host risk factors.

The researchers detected HRV in 41.7 percent of samples, in 107 samples as the only agent and in 74 samples as coinfections, mainly with RSV (43.2 percent). Moderate-to-severe symptoms were seen with 28.9 and 51.3 percent of the single and coinfections, respectively (P = 0.004). Coinfections were associated with lower respiratory tract symptoms and with some disease severity parameters, such as hospitalization. RSV was the most important virus associated with severe disease in coinfections. Comorbidities associated with disease severity included prematurity, cardiomyopathies, and noninfectious respiratory diseases (P = 0.007).

"Our study showed that HRV was a common pathogen of respiratory disease in children and was also involved in severe cases, causing symptoms of the ," the authors write.


Explore further

Molecular dissection of respiratory syncytial virus infection

More information: Abstract
Full Text (subscription or payment may be required)
Journal information: Pediatrics

Copyright © 2014 HealthDay. All rights reserved.

Citation: Disease severity factors ID'd for human rhinovirus (2014, January 13) retrieved 19 August 2019 from https://medicalxpress.com/news/2014-01-disease-severity-factors-idd-human.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
 shares

Feedback to editors

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more