Does high uric acid predispose diabetic patients to kidney disease?

January 15, 2014, University of Colorado Denver

Kidney disease poses one of the greatest burdens for people living with type 1 diabetes. A study newly awarded by the National Institutes of Health (NIH) will look at whether lowering uric acid levels can prevent people with type 1 diabetes from needing hemodialysis or kidney transplant.

David Maahs, MD, associate professor at the University of Colorado School of Medicine, Barbara Davis Center for Childhood Diabetes has been awarded a 5 year grant for $2.4 million dollars to evaluate the benefit of a drug called allopurinol, an FDA approved drug to lower uric acid. The money is part of a larger $24.3 million grant to the Joslin Diabetes Center.

"We are doing the study to see if we can slow down the decline of kidney function by decreasing uric acid. There are data showing moderately high serum uric acid levels increase progression to diabetic ," said Maahs. "If this is successful it could result in another method to prevent kidney disease in people with type 1 diabetes."

Ten to 15 percent of patients with type 1 diabetes develop advanced stage kidney disease. Uric acid is produced from the natural breakdown of your body's cells and from the foods you eat. Most uric acid is removed from the body in urine but if too much is produced, the level in the blood will increase. If increases then so does the risk for kidney disease.

Currently, the only ways to prevent is tight control of blood sugar and blood pressure. If allopurinol can halt the loss of in people with type 1 diabetes, it could be an additional safe and inexpensive way to prevent or delay kidney failure.

Explore further: Abnormal levels of uric acid in teens linked to high blood pressure

Related Stories

Abnormal levels of uric acid in teens linked to high blood pressure

May 1, 2012
Teens with high levels of uric acid appear to be at increased risk for high blood pressure, according to results of research from scientists at the Johns Hopkins Children's Center.

Vitamin C does not lower uric acid levels in gout patients

May 16, 2013
Despite previous studies touting its benefit in moderating gout risk, new research reveals that vitamin C, also known ascorbic acid, does not reduce uric acid (urate) levels to a clinically significant degree in patients ...

Recommended for you

Team provides insight into glucagon's role in diabetic heart disease

February 21, 2018
A UT Southwestern study reveals the hormone glucagon's importance to the development of insulin resistance and cardiac dysfunction during Type 2 diabetes, presenting opportunities to develop new therapies for diabetic diseases ...

Physical exercise reduces risk of developing diabetes: study

February 20, 2018
Exercising more reduces the risk of diabetes and could see seven million fewer diabetic patients across mainland China, Hong Kong and Taiwan, according to new research.

Researchers discover link between gut and type 1 diabetes

February 19, 2018
Scientists have found that targeting micro-organisms in the gut, known as microbiota, could have the potential to help prevent type 1 diabetes.

Researchers find existing drug effective at preventing onset of type 1 diabetes

February 15, 2018
A drug commonly used to control high blood pressure may also help prevent the onset of type 1 diabetes in up to 60 percent of those at risk for the disease, according to researchers at the University of Colorado Anschutz ...

Chemist designs diabetic treatment minus harmful side effects

February 9, 2018
A chemist in the College of Arts and Sciences (A&S) has figured out how to control glucose levels in the bloodstream without the usual side effects of nausea, vomiting or malaise.

Peptide improves glucose and insulin sensitivity, lowers weight in mice

February 8, 2018
Treating obese mice with catestatin (CST), a peptide naturally occurring in the body, showed significant improvement in glucose and insulin tolerance and reduced body weight, report University of California San Diego School ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.