Does high uric acid predispose diabetic patients to kidney disease?

January 15, 2014, University of Colorado Denver

Kidney disease poses one of the greatest burdens for people living with type 1 diabetes. A study newly awarded by the National Institutes of Health (NIH) will look at whether lowering uric acid levels can prevent people with type 1 diabetes from needing hemodialysis or kidney transplant.

David Maahs, MD, associate professor at the University of Colorado School of Medicine, Barbara Davis Center for Childhood Diabetes has been awarded a 5 year grant for $2.4 million dollars to evaluate the benefit of a drug called allopurinol, an FDA approved drug to lower uric acid. The money is part of a larger $24.3 million grant to the Joslin Diabetes Center.

"We are doing the study to see if we can slow down the decline of kidney function by decreasing uric acid. There are data showing moderately high serum uric acid levels increase progression to diabetic ," said Maahs. "If this is successful it could result in another method to prevent kidney disease in people with type 1 diabetes."

Ten to 15 percent of patients with type 1 diabetes develop advanced stage kidney disease. Uric acid is produced from the natural breakdown of your body's cells and from the foods you eat. Most uric acid is removed from the body in urine but if too much is produced, the level in the blood will increase. If increases then so does the risk for kidney disease.

Currently, the only ways to prevent is tight control of blood sugar and blood pressure. If allopurinol can halt the loss of in people with type 1 diabetes, it could be an additional safe and inexpensive way to prevent or delay kidney failure.

Explore further: Abnormal levels of uric acid in teens linked to high blood pressure

Related Stories

Abnormal levels of uric acid in teens linked to high blood pressure

May 1, 2012
Teens with high levels of uric acid appear to be at increased risk for high blood pressure, according to results of research from scientists at the Johns Hopkins Children's Center.

Vitamin C does not lower uric acid levels in gout patients

May 16, 2013
Despite previous studies touting its benefit in moderating gout risk, new research reveals that vitamin C, also known ascorbic acid, does not reduce uric acid (urate) levels to a clinically significant degree in patients ...

Recommended for you

Genetic discovery may help better identify children at risk for type 1 diabetes

January 17, 2018
Six novel chromosomal regions identified by scientists leading a large, prospective study of children at risk for type 1 diabetes will enable the discovery of more genes that cause the disease and more targets for treating ...

Women who have gestational diabetes in pregnancy are at higher risk of future health issues

January 16, 2018
Women who have gestational diabetes mellitus (GDM) during pregnancy have a higher than usual risk of developing type 2 diabetes, hypertension, and ischemic heart disease in the future, according to new research led by the ...

Diabetes gene found that causes low and high blood sugar levels in the same family

January 15, 2018
A study of families with rare blood sugar conditions has revealed a new gene thought to be critical in the regulation of insulin, the key hormone in diabetes.

Discovery could lead to new therapies for diabetics

January 12, 2018
New research by MDI Biological Laboratory scientist Sandra Rieger, Ph.D., and her team has demonstrated that an enzyme she had previously identified as playing a role in peripheral neuropathy induced by cancer chemotherapy ...

Enzyme shown to regulate inflammation and metabolism in fat tissue

January 11, 2018
The human body has two primary kinds of fat—white fat, which stores excess calories and is associated with obesity, and brown fat, which burns calories in order to produce heat and has garnered interest as a potential means ...

Big strides made in diabetes care

January 5, 2018
(HealthDay)—This past year was a busy, productive one for diabetes research and care.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.