How can vaccination be improved to eradicate avian influenza H5N1 in Indonesia?

January 13, 2014 by Jh (Annet) Blanken, Wageningen University
How can vaccination be improved to eradicate avian influenza H5N1 in Indonesia?

To answer this question, Okti Nadia Poetri researched the effect of vaccination to stop the spread of avian influenza in Indonesia. On January 21 Poetri will defence her thesis of this research.Highly pathogenic avian influenza (HPAI) also known as 'bird flu', is considered to be a major threat to both poultry farming and to public health. In Thailand and in Europe HPAI H5N1 is eradicated, mainly because of stamping out and practicing stringent biosafety measures. When HPAI H5N1 occurred in Indonesia in 2004 farmers were not prepared to adhere to stamping out among others because of the lack of a compensation regime, causing the virus to spread further. Not only poultry is frequently infected with avian influenza in Indonesia, so far no other country has had as many cases of human infections with bird flu.

The current way to control in Indonesia is by the vaccination of poultry kept in large commercial poultry farms. Poetri studied vaccination effectiveness as well as the cause of outbreaks of avian influenza in populations of vaccinated chickens.

Poetri describes how by performing serology in the laboratory test it can be predicted whether a specific vaccine strain can offer protection against a circulating virus. This would in turn reduce animal experiments necessary to assess vaccine efficacy. Her research may eventually contribute to an improvement of the current vaccination strategy.

Guus Koch, PhD, CVI, supported Poetri as co-supervisor in her research. Ivo Claassen, PhD, CVI, worked several years in Indonesia supporting the Indonesian-Netherlands Partnership on the Prevention and Control of Highly Avian Influenza and met Poetri who got involved in the research on effectiveness of the vaccination for HPAI H5N1.

Explore further: FDA approves H5N1 avian influenza vaccine

Related Stories

FDA approves H5N1 avian influenza vaccine

November 26, 2013
(HealthDay)—The U.S. Food and Drug Administration has approved the first adjuvanted vaccine for the prevention of H5N1 influenza in adults at greater-than-average risk of exposure.

Culling more effective than vaccinating

August 8, 2011
In economic and epidemiological terms, the practice of culling on farms within a radius of 1 to 3 km of infected farms is the best method of combating Highly Pathogenic Avian Influenza (HPAI). Vaccinating chickens within ...

Indonesia says it has found more virulent bird flu strain

December 11, 2012
Indonesia has identified the bird flu virus that killed hundreds of thousands of ducks in recent weeks as a more virulent type which is new to the country, according to a letter seen Tuesday.

Toddler is Cambodia's 6th bird flu death of year

February 13, 2013
(AP)—A 3-year-old Cambodian girl has become the sixth person to die from bird flu in the country this year.

Bird flu claims sixth victim this year in Indonesia

March 27, 2012
A 17-year old construction worker has died of bird flu on Indonesia's Lombok island, the sixth death from the virulent disease this year, a health ministry official said Tuesday.

Recommended for you

New study offers insights on genetic indicators of COPD risk

January 16, 2018
Researchers have discovered that genetic variations in the anatomy of the lungs could serve as indicators to help identify people who have low, but stable, lung function early in life, and those who are particularly at risk ...

Previous influenza virus exposures enhance susceptibility in another influenza pandemic

January 16, 2018
While past exposure to influenza A viruses often builds immunity to similar, and sometimes different, strains of the virus, Canadian researchers are calling for more attention to exceptions to that rule.

Don't hold your nose and close your mouth when you sneeze, doctors warn

January 15, 2018
Pinching your nose while clamping your mouth shut to contain a forceful sneeze isn't a good idea, warn doctors in the journal BMJ Case Reports.

New antifungal provides hope in fight against superbugs

January 12, 2018
Microscopic yeast have been wreaking havoc in hospitals around the world—creeping into catheters, ventilator tubes, and IV lines—and causing deadly invasive infection. One culprit species, Candida auris, is resistant ...

Dengue takes low and slow approach to replication

January 11, 2018
A new study reveals how dengue virus manages to reproduce itself in an infected person without triggering the body's normal defenses. Duke researchers report that dengue pulls off this hoax by co-opting a specialized structure ...

Different strains of same bacteria trigger widely varying immune responses

January 11, 2018
Genetic differences between different strains of the same pathogenic bacterial species appear to result in widely varying immune system responses, according to new research published in PLOS Pathogens.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.