AANS: Stem cells may aid stroke patients

April 10, 2014
AANS: stem cells may aid stroke patients

(HealthDay)—Intraparenchymal transplantation of human modified bone marrow-derived stromal cells in chronic stroke patients is safe, feasible, and results in improved neurologic function, according to a study presented at the annual meeting of the American Association of Neurological Surgeons, held from April 5 to 9 in San Francisco.

Gary K. Steinberg, M.D., Ph.D., from Stanford University in California, and colleagues conducted a two-center open-label safety, dose escalation feasibility study in the first North American trial of intraparenchymal transplantation of bone marrow-derived cell therapy (six each with 2.5M, 5M and I0M cells) for chronic (18 individuals; 18 to 75 years old; six to 60 months post subcortical middle cerebral artery ).

The researchers found that over the course of follow-up (more than six months in 16 patients and more than 12 months in 12 patients) there were three serious adverse events (SAEs) related to the surgery, but not to the cells (seizure, subdural hematoma, pneumonia), and two SAEs unrelated to either surgery or cells (, delayed new ). There were no changes in cytokine levels, human leukocyte antigen antibody levels, and peripheral blood mononuclear cell function. Assessment scales (National Institutes of Health Stroke Scale, European Stroke Scale, Fugl-Meyer) all showed a significant benefit in neurologic outcomes. Within 24 hours of surgery, two patients showed remarkable improvement in their motor function, effects which have been sustained during follow-up (20 months and five months).

"Although this was primarily a safety study, we found a significant recovery of neurologic function in patients overall at six months that is sustained at one year," Steinberg said in a statement.

Several authors disclosed financial ties to the medical device and regenerative medicine industries.

Explore further: Stem cells show promise for stroke recovery

More information: Press Release
More Information

Related Stories

Stem cells show promise for stroke recovery

April 7, 2014
(HealthDay)—In an early test, researchers report they've safely injected stem cells into the brains of 18 patients who had suffered strokes. And two of the patients showed significant improvement.

Therapy using stem cells, bone marrow cells, appears safe for patients with ischemic cardiomyopathy

November 18, 2013
Alan W. Heldman, M.D., of the University of Miami Miller School of Medicine, and colleagues conducted a study to examine the safety of transendocardial stem cell injection (TESI) with autologous mesenchymal stem cells and ...

New human trial shows stem cells are effective for failing hearts

March 31, 2014
Patients with severe ischemic heart disease and heart failure can benefit from a new treatment in which stem cells found in bone marrow are injected directly into the heart muscle, according to research presented at the American ...

Safety results of intra-arterial stem cell clinical trial for stroke presented

October 11, 2012
Early results of a Phase II intra-arterial stem cell trial for ischemic stroke showed no adverse events associated with the first 10 patients, allowing investigators to expand the study to a targeted total of 100 patients.

Bone marrow stem cells show promise in stroke treatment

April 9, 2014
Stem cells culled from bone marrow may prove beneficial in stroke recovery, scientists at UC Irvine's Sue & Bill Gross Stem Cell Research Center have learned.

Stem cells aid recovery from stroke

January 27, 2013
Stem cells from bone marrow or fat improve recovery after stroke in rats, finds a study published in BioMed Central's open access journal Stem Cell Research & Therapy. Treatment with stem cells improved the amount of brain ...

Recommended for you

Therapeutic antibodies protected nerve–muscle connections in a mouse model of Lou Gehrig's disease

February 20, 2018
Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, causes lethal respiratory paralysis within several years of diagnosis. There are no effective treatments to slow or halt this devastating disease. Mouse ...

Brain liquefaction after stroke is toxic to surviving brain: study

February 20, 2018
Scientists have known for years that the brain liquefies after a stroke. If cut off from blood and oxygen for a long enough period, a portion of the brain will die, slowly morphing from a hard, rubbery substance into liquid ...

Brain immune system is key to recovery from motor neuron degeneration

February 20, 2018
The selective demise of motor neurons is the hallmark of Lou Gehrig's disease, also known as amyotrophic lateral sclerosis (ALS). Yet neurologists have suspected there are other types of brain cells involved in the progression ...

Brain aging may begin earlier than expected

February 20, 2018
Physicists have devised a new method of investigating brain function, opening a new frontier in the diagnoses of neurodegenerative and ageing related diseases.

Every experience that the brain perceives is unique

February 20, 2018
Neuronal activity in the prefrontal cortex represents every experience as "novel." The neurons adapt their activity accordingly, even if the new experience is very similar to a previous one. That is the main finding of a ...

Electrical implant reduces 'invisible' symptoms of man's spinal cord injury

February 19, 2018
An experimental treatment that sends electrical currents through the spinal cord has improved "invisible" yet debilitating side effects for a B.C. man with a spinal cord injury.

1 comment

Adjust slider to filter visible comments by rank

Display comments: newest first

Sinister1812
not rated yet Apr 11, 2014
Well derr. They've been saying that for 20 years now!!

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.