Walking may help protect kidney patients against heart disease and infections

April 3, 2014, American Society of Nephrology

Just a modest amount of exercise may help reduce kidney disease patients' risks of developing heart disease and infections, according to a study appearing in an upcoming issue of the Journal of the American Society of Nephrology (JASN).

Heart disease and infection are major complications and the leading causes of death in patients with chronic . It is now well established that immune system dysfunction is involved in both of these pathological processes. Specifically, impaired predisposes to infection, while persistent immune activation leads to a state of chronic inflammation that can damage the insides of blood vessels and increase risk. Physical exercise may confer benefits by exerting anti-inflammatory effects and enhancing immunity, but such effects have been largely unexplored in kidney disease.

João Viana, PhD, Nicolette Bishop, PhD (Loughborough University, in the UK), and Alice Smith, PhD (University of Leicester) and their colleagues designed a study to explore the impact of exercise on a range of immune and inflammatory parameters in patients with .

In an acute exercise study conducted in 15 patients, 30 minutes of walking improved the responsiveness of immune cells called neutrophils to a bacterial challenge in the post-exercise period. It also induced a systemic anti-inflammatory environment in the body.

In a regular exercise study, six months of regular walking (30 minutes/day, five times/week) reduced immune cell activation and markers of systemic inflammation in 20 patients compared with another 20 patients who did not increase their usual activity levels over the same period of time.

"Thus, exercise exerts anti-inflammatory effects in patients with kidney disease and may in this way reduce their high risk for heart disease," said Dr. Viana. "Our study also found no evidence that this level of exercise might be harmful to the immune system in people with kidney disease."

Explore further: Autoimmune drug may help prevent kidney disease caused by diabetes

More information: The article, entitled "Evidence for Anti-Inflammatory Effects of Exercise in CKD," will appear online at jasn.asnjournals.org/ on April 3, 2014.

Related Stories

Autoimmune drug may help prevent kidney disease caused by diabetes

March 27, 2014
A drug currently used to treat autoimmune disease may also help prevent the kidney-damaging effects of diabetes, according to a study appearing in an upcoming issue of the Journal of the American Society of Nephrology (JASN). ...

Physical activity may slow kidney function decline in patients with kidney disease

December 12, 2013
Increased physical activity may slow kidney function decline in patients with kidney disease, according to a study appearing in an upcoming issue of the Journal of the American Society of Nephrology (JASN). The findings suggest ...

Kidney patients may gain from less salt

January 31, 2014
(Medical Xpress)—Reducing salt consumption may help prolong the lives of patients with chronic kidney disease, a study from The University of Queensland study has found

Statins could ease coughing in lung disease patients, study finds

March 24, 2014
Common cholesterol-lowering drugs could provide relief to patients suffering from a chronic lung disease, a study has shown.

Daily walk of just 3 km can reduce risk of hospitalization for respiratory problems

February 18, 2014
New research in Respirology shows that suffers of Chronic obstructive pulmonary disease (COPD) can reduce their risk of being hospitalized with severe attacks, by maintaining an exercise regime of walking between three to ...

Exercise effective and safe in patients with moderate kidney disease

August 22, 2013
A structured exercise and lifestyle program can improve fitness, body composition, and heart function in patients with kidney disease, according to a study appearing in an upcoming issue of the Clinical Journal of the American ...

Recommended for you

Blood signature could improve early tuberculosis diagnosis

June 19, 2018
A gene signature in the bloodstream could reveal whether someone is going to develop active tuberculosis (TB) disease months before symptoms begin. Such a signature has now been developed by a team led by the Francis Crick ...

Scientists uncover a factor important for Zika virus host species restriction

June 19, 2018
Princeton University researchers Qiang Ding, Alexander Ploss, and colleagues have identified one of the mechanisms by which Zika virus (ZIKV) circumvents immune control to replicate in human cells. The paper detailing this ...

Toothpaste and hand wash may contribute to antibiotic resistance

June 19, 2018
A common ingredient in toothpaste and hand wash could be contributing to antibiotic resistance, according to University of Queensland research.

Combining different malaria vaccines could reduce cases by 91 percent

June 19, 2018
Using two experimental anti-malarial vaccines, which work in different ways, can greatly reduce the number of malaria infections in animal studies.

Children's immune system could hold the key to preventing sepsis

June 19, 2018
Children's immune systems could hold the key to preventing life-threatening infections and sepsis, a new study has revealed.

Beware of getting a tattoo if your immune system isn't up to scratch, doctors warn

June 18, 2018
Getting a tattoo may have some unexpected complications if your immune system isn't up to scratch, warn doctors in the journal BMJ Case Reports.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.