Large study explores combined influence of genetics and lifestyle in the development of Alzheimer's disease

April 3, 2014, Cardiff University

A global study involving more than one million people worldwide will explore the relationship between genetics and lifestyle in the development of Alzheimer's disease.

Led by scientists from Cardiff University, the £6M project will combine the power of multiple epidemiological studies from around the world to produce the most comprehensive understanding of the disease's risk to date.

Information gleaned from these studies about and lifestyle influences will provide scientists with the best evidence yet for creating a fuller picture of why the disease develops and the varying degrees of risk it poses to different individuals.

"For too long scientists studying Alzheimer's have been working in silos, engaged in a single-minded 'race' to try and beat the disease. That's simply not going to happen unless we pull together," said Principal Investigator Professor Julie Williams, Head of Neurodegeneration at Cardiff University School of Medicine's Medical Research Council (MRC) Centre on Neuropsychiatric Genetics and Genomics.

"The aim of our study is to harmonise the research of scientists studying the of Alzheimer's with the work of those studying the lifestyle influences, with the ultimate goal to creating more personalised treatments for the disease - and, better yet, treatments that offset it altogether. Put simply, this is a study large enough to get answers.

"The insights gleaned will pave the way for a new era of therapies for the disease. We predict that in future, based on this unrivalled data, GPs may be able run a simple test to analyse a patient's risk of developing Alzheimer's. A combination of gene therapy, drugs and lifestyle changes could then be prescribed to reduce that risk," she added.

Based on the genetic data of more than a million people aged 65+ - and some younger - from Europe, US, Australia and Asia, researchers will be able to paint a picture of the genetic architecture underpinning Alzheimer's. The size of the study is significant, as a larger sample of data allows for more accuracy and a stronger basis for analysis. New biomarker data gleaned from the study will help scientists understand what triggers the disease, enabling them to identify new genetic and , as well as the factors that mitigate risk, leading to a better management of the condition for future generations.

Susceptibility to Alzheimer's will be encoded using a polygenic risk score which will take into account an individual's genetic makeup, combined with information about their lifestyle and diet. This new information will improve scientific understanding of the pre-symptomatic phase of the disease opening up the possibility for early clinical trials on those who are asymptomatic, and search for a way not to merely treat the disease but to prevent its manifestation.

Researchers will also be able to distinguish those at a 'high-risk' status from those of a lower risk and will in the long-term provide an opportunity for early intervention, saving the brain before it reaches a state of irreversible damage. Previous studies conducted by Cardiff University have uncovered a total of 21 susceptibility genes linked to Alzheimer's. The findings revealed significant evidence that shows clusters of genes implicating potential biological pathways in the disease, including cholesterol transport and the immune system.

Dr Eric Karran, Director of Research at Alzheimer's Research UK, said:

"We are proud to be supporting this important research, which will bring together researchers from different disciplines across the globe. This type of collaboration is crucial for driving research forward: it's important to combine insights from different strands of research in order to gain a more complete understanding of Alzheimer's.

"Our risk of developing Alzheimer's is likely to be down to a complex mix of genetic and environmental factors, and the better we understand these factors the greater our chance of finding ways to intervene. With half a million people in the UK currently living with Alzheimer's, we urgently need to find treatments that can make a difference."

Explore further: New risk gene illuminates Alzheimer's disease

Related Stories

New risk gene illuminates Alzheimer's disease

February 25, 2014
A team of international scientists, including a researcher from Simon Fraser University, has isolated a gene thought to play a causal role in the development of Alzheimer's disease. The Proceedings of the National Academy ...

Researchers identify variation in gene PLD3 can increase risk of late-onset Alzheimer’s disease

December 24, 2013
(Medical Xpress)—A new study, part-funded by the Medical Research Council (MRC), the Wellcome Trust and Alzheimer's Research UK, has shown that a fault in a gene called phospholipase D3 (PLD3) can contribute to the overproduction ...

Tackling Alzheimer's

February 2, 2012
(Medical Xpress) -- Specific genes known to be one of the causes of a rare type of Alzheimer’s, which runs in families, are unlikely to contribute to the more common form of the disease, University scientists have uncovered.

A genetic answer to the Alzheimer's riddle?

August 14, 2013
What if we could pinpoint a hereditary cause for Alzheimer's, and intervene to reduce the risk of the disease? We may be closer to that goal, thanks to a team at the University of Kentucky. Researchers affiliated with the ...

Gene discovery offers new path for Alzheimer's research

July 9, 2013
A new gene variant has been linked to Alzheimer's disease, and this association is strongest among elderly blacks.

Alzheimer's risk gene may begin to affect brains as early as childhood

December 3, 2013
People who carry a high-risk gene for Alzheimer's disease show changes in their brains beginning in childhood, decades before the illness appears, new research from the Centre for Addiction and Mental Health (CAMH) suggests.

Recommended for you

Rocky start for Alzheimer's drug research in 2018

January 19, 2018
The year 2018, barely underway, has already dealt a series of disheartening blows to the quest for an Alzheimer's cure.

Alzheimer's disease: Neuronal loss very limited

January 17, 2018
Frequently encountered in the elderly, Alzheimer's is considered a neurodegenerative disease, which means that it is accompanied by a significant, progressive loss of neurons and their nerve endings, or synapses. A joint ...

Anxiety: An early indicator of Alzheimer's disease?

January 12, 2018
A new study suggests an association between elevated amyloid beta levels and the worsening of anxiety symptoms. The findings support the hypothesis that neuropsychiatric symptoms could represent the early manifestation of ...

One of the most promising drugs for Alzheimer's disease fails in clinical trials

January 11, 2018
To the roughly 400 clinical trials that have tested some experimental treatment for Alzheimer's disease and come up short, we can now add three more.

Different disease types associated with distinct amyloid-beta prion strains found in Alzheimer's patients

January 9, 2018
An international team of researchers has found different disease type associations with distinct amyloid-beta prion strains in the brains of dead Alzheimer's patients. In their paper published in Proceedings of the National ...

Advances in brain imaging settle debate over spread of key protein in Alzheimer's

January 5, 2018
Recent advances in brain imaging have enabled scientists to show for the first time that a key protein which causes nerve cell death spreads throughout the brain in Alzheimer's disease - and hence that blocking its spread ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.