Bone morphogenetic protein can replace autogenous bone

May 23, 2014
Bone morphogenetic protein can replace autogenous bone

(HealthDay)—Bone morphogenetic protein (BMP) is a good alternative to autogenous bone graft in certain cases of lumbar arthrodesis for degenerative disc disease (DDD), according to research published in the May issue of the Journal of Spinal Disorders & Techniques.

Andriy Noshchenko, Ph.D., from the University of Colorado in Aurora, and colleagues conducted a systematic literature review to identify studies comparing the perioperative and long-term postoperative effectiveness of BMP versus iliac crest autologous bone graft (ICBG) for lumbar arthrodesis in adults with DDD.

The researchers identified eight randomized controlled clinical trials (1,138 participants). The BMP and ICBG groups had similar pooled two-year postoperative clinical outcomes. There was increased pain and complications at the donor site (P < 0.01) associated with ICBG. With BMP, the pooled average operative time was 21 minutes less than with ICBG (P < 0.001). In the BMP group, the pooled rate of additional surgical treatment was two times less than in the ICBG groups (P = 0.006). Additionally, at 24-month follow-up, the pooled risk of nonunion was two times less in the BMP versus in the ICBG groups (P = 0.037), although this effect may have been biased.

"BMP, in particular recombinant human BMP-2, is a good alternative to autogenous , especially in cases when harvesting of autologous bone is contraindicated or undesirable, operation time is limited, and there are no contraindications for BMP use," the authors write. "However, the current study did not reveal evidence robust enough to develop strong medical recommendations concerning BMP use for lumbar arthrodesis in ."

Explore further: Spinal fusion material, BMP, increases risk of benign tumors, not cancer

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Spinal fusion material, BMP, increases risk of benign tumors, not cancer

September 6, 2013
Using a certain bone grafting material for spinal fusion, one of the most common procedures for people with painful vertebral deteriorations, does not appear to result in higher rates of cancer, according to researchers at ...

Gene therapy as a new option for bone defects

December 7, 2012
(Medical Xpress)—Gene therapy involving modified stem cells obtained from fatty tissue and bone marrow could represent a new option for the treatment of severe orthopaedic injuries to the extremities. This treatment has ...

Bone growth factor may increase benign tumors but not malignant cancer

September 6, 2013
Patients undergoing spinal fusion surgery with bone morphogenetic protein (BMP) appear to be at increased risk of benign tumors—but not cancers, reports a study in the September issue of Neurosurgery, official journal of ...

Researchers explore function of cancer-causing gene

March 26, 2014
Developmental biologists at the University of Georgia are discovering new roles for a specific gene known as Max's Giant Associated protein, or MGA. A little studied protein, MGA appears to control a number of developmental ...

Arthrodesis ups complications, costs for spondylolisthesis

December 10, 2013
(HealthDay)—For patients with lumbar spondylolisthesis, decompressive laminectomy and spinal arthrodesis is associated with lower reoperation rates, but with higher complication rates and higher overall costs than laminectomy ...

Recommended for you

A sodium surprise: Engineers find unexpected result during cardiac research

July 20, 2017
Irregular heartbeat—or arrhythmia—can have sudden and often fatal consequences. A biomedical engineering team at Washington University in St. Louis examining molecular behavior in cardiac tissue recently made a surprising ...

Want to win at sports? Take a cue from these mighty mice

July 20, 2017
As student athletes hit training fields this summer to gain the competitive edge, a new study shows how the experiences of a tiny mouse can put them on the path to winning.

Engineered liver tissue expands after transplant

July 19, 2017
Many diseases, including cirrhosis and hepatitis, can lead to liver failure. More than 17,000 Americans suffering from these diseases are now waiting for liver transplants, but significantly fewer livers are available.

Lunatic Fringe gene plays key role in the renewable brain

July 19, 2017
The discovery that the brain can generate new cells - about 700 new neurons each day - has triggered investigations to uncover how this process is regulated. Researchers at Baylor College of Medicine and Jan and Dan Duncan ...

'Smart' robot technology could give stroke rehab a boost

July 19, 2017
Scientists say they have developed a "smart" robotic harness that might make it easier for people to learn to walk again after a stroke or spinal cord injury.

New animal models for hepatitis C could pave the way for a vaccine

July 19, 2017
They say that an ounce of prevention is worth a pound of cure. In the case of hepatitis C—a disease that affects nearly 71 million people worldwide, causing cirrhosis and liver cancer if left untreated—it might be worth ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.