DDW: Endoscopic L-menthol spray ups colon polyp detection

May 6, 2014
DDW: endoscopic L-menthol spray ups colon polyp detection

(HealthDay)—For patients undergoing colonoscopy, L-menthol sprayed directly onto the colonic mucosa improves the adenoma detection rate, according to a study presented at the annual Digestive Disease Week, held from May 3 to 6 in Chicago.

Noting that L-menthol has suppressed gastric peristalsis in , Ken Inoue, M.D., from the Kyoto Prefectural University of Medicine in Japan, and colleagues examined its efficacy by endoscopic spray in . Two hundred twenty-six patients were randomized to receive 320 mg L-menthol (118 patients) or placebo (108 patients), which was directly sprayed on the cecum. If and when intestinal peristalsis occurred, L-menthol was sprayed again in the L-menthol group.

The researchers found that in the L-menthol group the adenoma detection rate was significantly higher than in the placebo group (60.2 versus 42.6; P = 0.0083). In the L-menthol group, a significantly higher proportion of patients had no peristalsis after treatment, compared with the placebo group (71.2 versus 30.9 percent; P < 0.0001). The peristaltic scores were significantly lower for L-menthol-treated than before treatment (P < 0.0001 after treatment). In the , the scores were not significantly different before and after treatment. No adverse effects were observed in either group.

"The results suggest that the suppression of colonic peristalsis by L-menthol sprayed directly onto the colonic mucosa improves the adenoma detection rate," the authors write.

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