New research explores how smoking while pregnant leads to other diseases

May 5, 2014, University of Utah Health Sciences

While many parents-to-be are aware that the health of their baby starts before they've actually arrived into the world, recent research reveals that "harm" (i.e., tobacco smoke, dirty air, poor nutrition, even preeclampsia) may not present itself disease-wise until well into adulthood or when a second harmful "hit" triggers the individual's susceptibility.

The results were announced at the Pediatric Academic Societies conference in Vancouver, British Columbia in May by Lisa Joss-Moore, Ph.D., University of Utah Department of Pediatrics.

"We're focusing on how certain prenatal events can cause you to develop lung disease and metabolic syndromes such as obesity, hypertension, diabetes and fatty liver," explains Joss-Moore, whose research reveals new insights into the molecular and structural changes occurring and possible targeted intervention preventing later-in-life diseases.

Results from her studies involving revealed that rat pups exposed to tobacco smoke while in utero but not postnatally (equivalent age of infant/toddler stage) were at a higher risk of developing metabolic disease and a change in lung structure and function later in life (i.e., respiratory issues).

"People have known that smoking while pregnant is not necessarily good for the baby, but people still do it. There's this assumption that the baby is insulated from major harm, which isn't true," says Joss-Moore, whose research is part of a 20-year-old field known as The Developmental Origins of Health and Disease.

"The affects from the smoke may initially be subtle until there is a second hit," explains Joss- Moore. For example, if you are exposed to prenatally, your lungs may be structured differently but not present a problem. However, later in life you may be exposed to second-hand smoke or inversion pollution, triggering or a .

Joss-Moore's research team is focusing on anything that causes the fetus to not grow properly. This could be related to maternal malnutrition, obesity, maternal hypertension, among other things. "Understanding the molecular mechanisms that link early life events to disease later on, allows us to see what pathways are being impacted and need fixing. Then, we can provide intervention," explains Joss-Moore. She has discovered that one of the "broken" molecular pathways is responsive to fatty acids. The pathway is deficient in Omega 3 Fatty Acid, so when it is supplemented with Omega 3, it repairs itself and the lung structure lasts into adulthood, in rats. "With enough molecular information, we will eventually be able to move this knowledge forward into clinical trials."

Explore further: Maternal smoking disrupts retinoid pathways in the developing fetal lung

Related Stories

Maternal smoking disrupts retinoid pathways in the developing fetal lung

May 31, 2012
Maternal smoking can lead to lung disease in babies, including asthma. New research published in BioMed Central's open access journal Respiratory Research shows that maternal smoking-related defects within the alveoli inside ...

Preclinical study suggests E-cigarettes may promote lung cancer in high-risk individuals

January 9, 2014
Exposing human lung cells with genetic mutations associated with high risk for lung cancer to the chemicals in electronic-cigarette (e-cigarette) vapor enhanced the cells' cancerous behaviors, according to preliminary results ...

Children exposed to cigarette smoke have increased risk of COPD in adulthood

March 15, 2012
A new study published in the journal Respirology reveals that children who are exposed to passive smoke have almost double the risk of developing chronic obstructive pulmonary disease (COPD) in adulthood compared with non-exposed ...

Obesity combined with exposure to cigarette smoke may pose new health concerns

September 11, 2013
Millions of people who are obese and smoke tobacco may face additional health problems—including their responses to common prescription medicines—that extend beyond the well-known links with cancer, heart attacks and ...

Occasional marijuana use doesn't harm lungs, study finds

January 12, 2012
Smoking marijuana on an occasional basis does not appear to significantly damage the lungs, according to a new study.

Want a good night's sleep in the New Year? Quit smoking

January 2, 2014
As if cancer, heart disease and other diseases were not enough motivation to make quitting smoking your New Year's resolution, here's another wake-up call: New research published in the January 2014 issue of The FASEB Journal ...

Recommended for you

NeuroNext biomarker study explores natural history of infantile-onset SMA

January 9, 2018
Research led by The Ohio State University Wexner Medical Center to define the natural history of infantile-onset spinal muscular atrophy (SMA) has been "critical" to accelerate the development of effective therapies and hasten ...

No link between childhood lead levels, later criminality

December 27, 2017
(HealthDay)— Exposure to higher levels of lead during early childhood can affect neurological development—but does that mean affected kids are doomed to delinquency?

Early puberty in girls may take mental health toll

December 26, 2017
(HealthDay)—A girl who gets her first menstrual period early in life—possibly as young as 7—has a greater risk for developing depression and antisocial behaviors that last at least into her 20s, a new study suggests.

Technology not taking over children's lives despite screen-time increase

December 21, 2017
With children spending increasing amounts of time on screen-based devices, there is a common perception that technology is taking over their lives, to the detriment and exclusion of other activities. However, new Oxford University ...

Higher blood sugar in early pregnancy raises baby's heart-defect risk

December 15, 2017
Higher blood sugar early in pregnancy raises the baby's risk of a congenital heart defect, even among mothers who do not have diabetes, according to a study led by researchers at the Stanford University School of Medicine.

Injuries from window blinds send two children to the emergency department every day

December 11, 2017
Most homes have them. They help keep our rooms warm or cold and even add a pop of color to tie the décor together. But window blinds can cause serious injuries or even death to young children. A new study from the Center ...


Adjust slider to filter visible comments by rank

Display comments: newest first

1 / 5 (1) May 05, 2014
"The hospital are letting pregnant women smoke on there premisis? How shameful. Pregnant women who smoke during pregnancy should be charged with child abuse. I really hate seeing it."

In more rational times, before the anti-tobacco hysteria began in earnest, women who smoked continued to smoke and enjoy other normal pleasures of life without guilt during their pregnancies. Many even smoked during labour to help them relax and take the edge off their pain. If their doctors mentioned smoking at all, it would be to advise them to perhaps cut down if they were heavy smokers, something which most did intuitively because they didn't "feel" like smoking as much.
But pity the poor smoker today who becomes pregnant, because she will be told that if she continues to smoke at all (or have any alcohol or caffeine) during her pregnancy, she is putting her developing fetus at high risk of death or disability.

Nothing could be further from the truth.

Though there is considerable evidence showing that on average the babies of women who smoke during pregnancy weigh on average a few ounces less than babies of women who do not smoke and that the rate of low birthweight babies is somewhat higher for smokers, there is no credible evidence for the hyperbolic claims that the babies of smokers have a higher mobidity and mortality rate. Quite the contrary, the babies of women who smoke during pregnancy have a better survival rate ounce for ounce, a somewhat lower rate of congenital defects, a lower rate of Down's syndrome, a lower rate of infant respiratory distress syndrome and a somewhat lower rate of childhood cancer than do the babies of non-smokers.

Dr. Richard L. Naeye, a leading obstetrical researcher who studied more than 58,000 pregnancies, states unequivocally:

"We recently found no significant association between maternal smoking and either stillbirths or neonatal deaths when information about the underlying disorders, obtained from placental examinations, was incorporated into the analyses. Similar analyses found no correlation between maternal smoking and preterm birth. The most frequent initiating causes of preterm birth, stillbirth, and neonatal death are acute chorioamnionitis, disorders that produce chronic low blood flow from the uterus to the placenta, and major congenital malformations. There is no credible evidence that cigarette smoking has a role in the genesis of any of these disorders.""

not rated yet May 05, 2014
Study: Babies' low serotonin levels cause SIDS – USATODAY.comhttp://www.usatod...st_N.htmCached][/url] – Similar
You +1'd this publicly. Undo
Feb 2, 2010 – Sudden infant death syndrome researchers say low serotonin may be what prevents infants from waking up when they inhale too much carbon …


Researchers may have solved the mystery of what makes some babies vulnerable to sudden infant death syndrome, or SIDS, which kills more than 2,300 babies a year.
Infants who died of SIDS had low levels of serotonin, a brain chemical that helps the brainstem regulate breathing, temperature, sleeping, waking and other automatic functions, according to an autopsy study in today's Journal of the American Medical Association.

Serotonin normally helps babies respond to high carbon-dioxide levels during sleep by helping them wake up and shift their head position to get fresh air, says senior author Hannah Kinney of Harvard Medical School and Children's Hospital Boston.

1 / 5 (1) May 05, 2014
The Junk Science that just keeps on giving................

Perhaps youd like to explain how the baby boomers the longest lived generation survived being born to smoking mothers and smoking fathers!

As usual you cant all you do Is try and find some chemical deficiency or another so called linked to path that you can tie back to smoking or the mythical second hand smoke to a disease. Now its diseases of the future...........What prey tell does the JUNK SCIENCE CRYSTAL BALL CALL FOR IN THE FUTURE! The great OZ only knows!
1 / 5 (1) May 05, 2014
People have known that smoking while pregnant is not necessarily good for the baby, but people still do it. There's this assumption that the baby is insulated from major harm, which isn't true," says Joss-Moore, whose research is part of a 20-year-old field known as The Developmental Origins of Health and Disease.

So the theory that the placental barrier can not be crossed is all a myth all of a sudden ehh!

The idea that babies are born addicted to drugs is very short on facts or even theory!

Go and read the so called signs and symptons of so called addicted babies it is absolutely HILLARIOUS the claims!

Then the idiot health Nazis want to make it a crime against the mother for using drugs and claiming the bay is addicted to without any proof of harm to begin with except to claim the baby was born with low birth weight!


Mothers Whose Babies Are Born Addicted To Drugs Can Be Charged Under New Law

WREG · 5 days ago

The law will let prosecutors charge women who ... Last year, more than 850 babies in Tennessee were born addicted to drugs, because of their mother ...

(Memphis) Doctors at CHOICES for Reproductive Health call a new law unconstitutional, but Memphis area lawmakers are the ones who pushed for it in the first place.

The law will let prosecutors charge women who give birth to drug-addicted babies with a crime for hurting their kids.

District Attorney Amy Weirich said, "These would have to be illegal drugs – cocaine, marijuana, heroine – a day or two days before giving birth."

Last year, more than 850 babies in Tennessee were born addicted to drugs, because of their mother's habit.

But advocates for women say this law moves in the wrong direction.

Allison Glass of Healty and Free Tennessee said, "It's going to hurt babies, it's going to hurt mothers, it's going to tear families apart."

Glass agrees the state needs to do something about the number of drug addicted babies, but she says this isn't it.

She's afraid it will keep women from getting necessary prenatal care, and possibly lie to their doctors to avoid charges.

Glass added, "There is a real fear that it is going to lead women to have unwanted abortions because they're trying to avoid jail."

District Attorney Amy Weirich disagrees.

She says this law has been on the books before, and it works to keep women in treatment by giving them limited options.

"If they give birth and the baby test positive they're given a citation to show up in drug court and they're given the opportunity to work the drug treatment program."

And if they don't they go to jail.

Doctors hope this law will start getting national attention and possibly be brought to the attention of the Supreme Court.
1 / 5 (1) May 05, 2014

How is HIV transmitted to a baby?

The exact way that transmission (when the virus passes from one person to another) from mother to baby happens is still unknown.

Mother to baby transmission is known as vertical transmission. The majority of vertical transmissions happen near the time of, or during, labour and delivery (when the baby is being born). Vertical transmission can also occur through breastfeeding.

Certain risk factors seem to make transmission much more likely. The biggest of these is the mother's viral load, which means the amount of virus in your blood.

As with treatment for anyone with HIV, one important goal is to reach an undetectable viral load. Viral load tests measure the amount of virus in your blood. The measurements are in copies per millilitre (copies/ mL). Undetectable viral load is currently considered to be below 50 copies/mL. When we talk about an undetectable viral load in this guide, that is what we mean. If a mother's viral load is undetectable when her baby is born, the risk of vertical transmission is almost zero.

This is particularly important at the time of delivery. Other risk factors include premature birth and lack of prenatal HIV care.

Practically all risk factors point to one thing: looking after mother's health.

Some key points to remember:
•The mother's health directly relates to the HIV status of the baby.
•Whether the baby's father is HIV positive will not affect whether the baby is born HIV positive.
•The HIV status of your new baby does not relate to the status of your other children.
1 / 5 (1) May 05, 2014

Creating public health epidemics and specialized depts. of junk science in universities to create the junk science for justification for criminal laws to force and coerce people to live as the public health Nazis COMMAND!

Its basicallt the new EUGENICS movement of the last century reborn again today across the globe likely led by the WORLD HEALTH ORGANIZATION! Along with all their Vector born trash science!
1 / 5 (1) May 05, 2014
The Alice in Wonderland World of Risk Factor Epidemiology | The Freedom2Choose Official Blog
From Wikipedia: "In epidemiology, a risk factor is a variable associated with an increased risk of disease or infection.

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.