Researchers examine intersection of aging, chronic disease

May 15, 2014

A new collection of articles appearing in The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences examine how the basic biology of aging drives chronic disease. Together, they highlight the value of the emerging field of geroscience, which uses an integrated approach to the study of diseases and disability associated with growing older.

Geroscience seeks to bridge the divide between studies of aging and studies of chronic disease, with the hope of understanding their complex relationship and pointing the way to novel interventions for disease, frailty, and disability.

The included articles were inspired by the inaugural summit convened by the National Institutes of Health's Trans-NIH Geroscience Interest Group. Under the continued theme of "Advances in Geroscience: Impact on Healthspan and Chronic Disease," these pieces focus on seven mechanisms that intersect aging and chronic disease pathways: inflammation, adaptation to stress, epigenetics, metabolism, macromolecular damage, proteostasis, and stem cells and regeneration.

"Although we can reasonably expect to live longer today than past generations did,the age-related disease burden we will have to confront has not changed," state the authors of the lead article. "With the proportion of older people among the global population being now higher than at any time in history and still expanding, maintain health into old has become a new and urgent frontier for modern medicine."

Each entry in the article collection uses the foundational concepts of geroscience to understand basic cellular and molecular underpinnings of aging as a principal risk factor for a variety of ; explore common mechanisms governing relationships between aging and chronic diseases; and identify new pathways for research collaboration.

Explore further: Chronic inflammation linked to less likelihood of healthy aging

Related Stories

Chronic inflammation linked to less likelihood of healthy aging

September 16, 2013
Chronic exposure to high levels of interleukin-6 was associated with a significantly lower likelihood of healthy aging, according to a study in CMAJ (Canadian Medical Association Journal).

Controlling the triggers of age-related inflammation could extend 'healthspan'

October 21, 2013
Inflammation is the common denominator of many chronic age-related diseases such as arthritis, gout, Alzheimer's, and diabetes. But according to a Yale School of Medicine study, even in the absence of a disease, inflammation ...

Supplement added to a standard diet improves health and prolongs life in mice

February 27, 2014
Activating a protein called sirtuin 1 extends lifespan, delays the onset of age-related metabolic diseases, and improves general health in mice. The findings, which appear online February 27 in the Cell Press journal Cell ...

Defining the new normal in aging

February 27, 2013
Diana McIntyre approaches her 80th birthday later this year with the same energy and zest for life of friends decades her junior. Aside from back surgery years ago, she's never been sick and, through a busy volunteer schedule, ...

Researchers study stem-cell therapy for feline kidney disease

January 9, 2014
Chronic kidney disease in older cats is the focus of a fifth clinical trial under way at Colorado State University's James L. Voss Veterinary Teaching Hospital, where veterinarians are exploring novel stem-cell therapy that ...

Recommended for you

Blowing smoke? E-cigarettes might help smokers quit

July 26, 2017
People who used e-cigarettes were more likely to kick the habit than those who didn't, a new study found.

Brain disease seen in most football players in large report

July 25, 2017
Research on 202 former football players found evidence of a brain disease linked to repeated head blows in nearly all of them, from athletes in the National Football League, college and even high school.

Safety of medical devices not often evaluated by sex, age, or race

July 25, 2017
Researchers at Yale and the University of California-San Francisco have found that few medical devices are analyzed to consider the influence of their users' sex, age, or race on safety and effectiveness.

Why you should consider more than looks when choosing a fitness tracker

July 25, 2017
A UNSW study of five popular physical activity monitors, including Fitbit and Jawbone models, has found their accuracy differs with the speed of activity, and where they are worn.

Dog walking could be key to ensuring activity in later life

July 24, 2017
A new study has shown that regularly walking a dog boosts levels of physical activity in older people, especially during the winter.

Study finds 275,000 calls to poison control centers for dietary supplement exposures from 2000 through 2012

July 24, 2017
U.S. Poison Control Centers receive a call every 24 minutes, on average, regarding dietary supplement exposures, according to a new study from the Center for Injury Research and Policy and the Central Ohio Poison Center, ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.