Emerging HIV epidemics among people who inject drugs in the Middle East and North Africa

June 19, 2014, Weill Cornell Medical College

HIV epidemics are emerging among people who inject drugs in several countries in the Middle East and North Africa. Though HIV infection levels were historically very low in the Middle East and North Africa, substantial levels of HIV transmission and emerging HIV epidemics have been documented among people who inject drugs in at least one-third of the countries of this region, according to findings published today in PLOS Medicine.

The HIV epidemics among people who inject drugs (PWID) are recent overall, starting largely around 2003 and continuing to grow in most countries. However, they vary across the region. In countries such as Afghanistan, Bahrain, Egypt, Iran, Morocco, Oman, and Pakistan, on average between 10 and 15 percent of PWID are HIV-positive. The HIV epidemics in these countries appear to be growing; in Pakistan, for example, the fraction of PWID who are HIV-infected increased from 11 percent in 2005 to 25 percent in 2011. In Iran, the HIV epidemic among PWID has stabilized at about 15 percent. There are, however, other countries where limited HIV transmission was found among PWID, such as in Jordan, Lebanon, Palestine and Syria.

"Not only have we found a pattern of new HIV epidemics among PWID in the region, but we found also indications that there could be hidden HIV epidemics among this marginalized population in several countries with still-limited data," said Ghina Mumtaz, lead author of the study and senior epidemiologist at the Infectious Disease Epidemiology Group at Weill Cornell Medical College-Qatar. "For example in Libya, the first study among people who inject drugs was conducted only recently and unveiled alarmingly high levels of HIV infection, suggesting that the virus has been propagating, unnoticed, among this population for at least a decade. Eighty-seven percent of PWID in Tripoli, the capital of Libya, were infected with HIV, one of the highest levels reported among PWID globally."

The study estimated that there are about 626,000 people who inject drugs in the Middle East and North Africa. This translates into 24 people who inject drugs for every 1,000 adults in this part of the world. These individuals are typically involved in several types of behavior that expose them to HIV infection, such as sharing of needles or syringes, a behavior reported by 18 to 28 percent of injecting users during their last injection across these countries.

"The levels of HIV infection among people who inject drugs tell only half of the story. We also see high levels of risky practices that will likely expose this population to further HIV transmission in the coming years," said Dr. Laith Abu-Raddad, principal investigator of the study and associate professor of public health in the Infectious Disease Epidemiology Group at Weill Cornell Medical College-Qatar. "We found that nearly half of people who inject drugs are infected with hepatitis C virus, another infection of concern that is also transmitted though sharing of needles and syringes."

"Since the HIV epidemics among people who inject drugs in the Middle East and North Africa are still overall in an early phase, there is a window of opportunity to prevent these epidemics from further growth. This will also limit the potential for HIV transmission to be bridged to other population groups," Mumtaz said.

Although the region overall lags behind in responding to the emerging HIV epidemics among PWID, several countries have made significant progress in building and expanding harm-reduction programs and integrating them within the socio-cultural fabric of the region. These programs refer to policies and strategies aimed at reducing the harmful consequences of injecting drug use, including needle- and syringe-exchange programs and opioid-substitution therapies.

"It is of priority that countries in the region expand HIV surveillance systems among PWID to detect and monitor these budding and growing HIV epidemics. About half of the of the region still lack sufficient data to assess the levels of HIV infection among this population, and we continue to discover these several years after their onset. We need to be ahead of the epidemic to prevent a public health burden that this region is largely not prepared to handle," Dr. Abu-Raddad said.

Explore further: Cutting HIV in drug users can benefit others' AIDS mortality

More information: www.plosmedicine.org/article/i … journal.pmed.1001663

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