Feds seek ways to expand use of addiction drug (Update)

June 18, 2014 by Matthew Perrone

The government's top drug abuse experts are struggling to find ways to expand use of a medicine that is considered the best therapy for treating heroin and painkiller addiction.

Sen. Carl Levin of Michigan on Wednesday pressed officials from the White House, the National Institute of Drug Abuse and other agencies to increase access to buprenorphine, a medication which helps control drug cravings and withdrawal symptoms. It remains underused a decade after its launch.

First approved in 2002—under a law crafted by Levin, a Democrat, and Utah Republican Sen. Orrin Hatch—buprenorphine was hailed as a major advance over methadone, the decades-old standard for addiction treatment. Among other advantages, buprenorphine has a lower risk of overdose and milder side effects. It can be prescribed as a take-home medication in the privacy of a doctor's office, helping patients avoid the stigma of going to a methadone clinic.

But even amid a national epidemic of drug abuse and addiction, access to buprenorphine remains limited by federal restrictions, inconsistent insurance coverage and a lack of acceptance by physicians.

"As long as we have too few doctors certified to prescribe bupe, we will be missing a major weapon in the fight against the ravages of addiction," Levin told the forum, which also included patients and non-government medical experts.

Only 4 percent of the 625,000 U.S doctors who are eligible to prescribe buprenorphine have received certification to use the drug, which comes as a pill or a film that dissolves under the tongue. Certification requires an eight hour training course in addiction medicine.

Meanwhile an estimated 2.5 million Americans are addicted to prescription painkillers or heroin, known collectively as opioids, and less than half are receiving medical treatment.

"It's somewhat paradoxical that physicians will use opioids to create a problem, but there seems to be reluctance to help address the problem," said Dr. Westley Clark of the Center for Substance Abuse Treatment. Clark and other experts noted that there is still a stigma attached to treating opioid addiction and many physicians are uninterested in learning how to use drugs like buprenorphine.

Government officials agreed that more training is needed to familiarize both medical students and experienced physicians with science showing that addiction can be successfully treated with medication.

Even among doctors who are certified to prescribe buprenorphine, federal law caps the number of patients they can treat at 100.

Dr. Corey Waller, an addiction specialist from Grand Rapids, Michigan, said he has a constant waiting list of patients trying to get a prescription.

"It's the only medication that has a limit of treatment capability out of all the medicines in the U.S.," said Waller, who also spoke on behalf of the American Society of Addiction Medicine. The group has proposed raising the cap to as high as 500 patients for physicians who complete 40 hours of training.

But federal officials cautioned against raising the number, noting that buprenorphine itself can be abused.

Dr. Nora Volkow, director of the National Institute on Drug Abuse, noted that buprenorphine overdoses are routinely reported in Europe, where the drug is less restricted. Other officials warned that raising the prescribing limit might lead to buprenorphine pill mills, where rogue doctors prescribe drugs indiscriminately in exchange for money from addicts.

Methadone and buprenorphine are themselves opioids, part of that class of highly addictive drugs that mimic the effect of the opium poppy. When dosed carefully though, both drugs can reduce opioid withdrawal symptoms— including anxiety, sweating, nausea and vomiting—without producing the euphoric high seen with drugs like heroin.

Despite similarities between methadone and buprenorphine, doctors and recovering addicts agree buprenorphine has clear benefits. Patients report less fatigue and mental fogginess on the newer drug. Most significantly, buprenorphine can be prescribed in an extended take-home supply, freeing patients from making daily trips to methadone clinics.

"It's a drug that allows us to lead a normal life," said Dr. John Kitzmiller, a Michigan doctor who recovered from his own opioid addiction using buprenorphine. "You can't live a normal life on methadone."

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