Pre-load stress echo benefits heart failure prediction

June 20, 2014
Pre-load stress echo benefits heart failure prediction

(HealthDay)—Pre-load stress echocardiography using leg-positive pressure (LPP) provides additional prognostic information beyond that provided by conventional Doppler echocardiography at rest in cases of mild heart failure, according to a study published online June 18 in JACC: Cardiovascular Imaging.

Hirotsugu Yamada, M.D., Ph.D., from Tokushima University Hospital in Japan, and colleagues performed transthoracic echocardiography with LPP in 202 with chronic cardiac disease. Patients were categorized based on left ventricular (LV) diastolic dysfunction using transmitral flow velocity as: restrictive or pseudonormal (PN) at , impaired relaxation (IR) at rest and during LPP (stable IR), and IR at rest and PN during LPP (unstable IR).

The researchers found that LPP increased LV end-diastolic pressure from 15.8 to 20.5 mm Hg in the unstable IR group and from 10.5 to 14.7 mm Hg in the stable IR group (both P < 0.001). Over an average of 548 days of follow-up, five patients had cardiac death, 37 had acute heart failure, four had an acute myocardial infarction, and seven had a stroke. In unstable IR the all-cause cardiac event rate was higher than in stable IR (P < 0.001), and was similar in the PN
group (P = 0.81). Similarly, in the unstable IR group event-free survival was significantly lower versus in stable IR (P = 0.003). Unstable IR was an independent predictor of all-cause cardiac events (hazard ratio: 8.0; P < 0.001).

"Pre-load stress echocardiography using LPP provides additional prognostic information in mild beyond that provided by conventional Doppler echocardiography at rest," the authors write.

Explore further: Liver insulin resistance correlates with cardiac risk

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Liver insulin resistance correlates with cardiac risk

April 16, 2012
(HealthDay) -- Liver insulin resistance (IR) may be a significant indicator of cardiovascular disease (CVD) risk among men, and correlates more closely with risk factors than whole-body insulin sensitivity, according to a ...

Activated carotid bodies key in metabolic disruption

April 17, 2013
(HealthDay)—Activation of carotid bodies (CB) by insulin may account for increased sympathoadrenal activity that results in insulin resistance (IR) and arterial hypertension, according to an experimental study published ...

Insulin resistance increases risk of colorectal adenomas

March 27, 2012
(HealthDay) -- Insulin resistance (IR) and central obesity, as measured by waist to hip ratio (WHR), are associated with a significantly increased risk of colorectal adenomas, especially in men, according to a study published ...

Study examines multivessel mortality rates

December 29, 2011
(Medical Xpress) -- A new study led by University at Albany School of Public Health Distinguished Professor Emeritus Edward L. Hannan finds a link between higher mortality rates and incomplete revascularization procedures ...

Recommended for you

A nanoparticle inhalant for treating heart disease

January 18, 2018
A team of researchers from Italy and Germany has developed a nanoparticle inhalant for treating people suffering from heart disease. In their paper published in the journal Science Translational Medicine, the group describes ...

Starting periods before age of 12 linked to heightened risk of heart disease and stroke

January 15, 2018
Starting periods early—before the age of 12—is linked to a heightened risk of heart disease and stroke in later life, suggests an analysis of data from the UK Biobank study, published online in the journal Heart.

'Decorated' stem cells could offer targeted heart repair

January 10, 2018
Although cardiac stem cell therapy is a promising treatment for heart attack patients, directing the cells to the site of an injury - and getting them to stay there - remains challenging. In a new pilot study using an animal ...

Two simple tests could help to pinpoint cause of stroke

January 10, 2018
Detecting the cause of the deadliest form of stroke could be improved by a simple blood test added alongside a routine brain scan, research suggests.

Exercise is good for the heart, high blood pressure is bad—researchers find out why

January 10, 2018
When the heart is put under stress during exercise, it is considered healthy. Yet stress due to high blood pressure is bad for the heart. Why? And is this always the case? Researchers of the German Centre for Cardiovascular ...

Heart-muscle patches made with human cells improve heart attack recovery

January 10, 2018
Large, human cardiac-muscle patches created in the lab have been tested, for the first time, on large animals in a heart attack model. This clinically relevant approach showed that the patches significantly improved recovery ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.