Pre-load stress echo benefits heart failure prediction

June 20, 2014
Pre-load stress echo benefits heart failure prediction

(HealthDay)—Pre-load stress echocardiography using leg-positive pressure (LPP) provides additional prognostic information beyond that provided by conventional Doppler echocardiography at rest in cases of mild heart failure, according to a study published online June 18 in JACC: Cardiovascular Imaging.

Hirotsugu Yamada, M.D., Ph.D., from Tokushima University Hospital in Japan, and colleagues performed transthoracic echocardiography with LPP in 202 with chronic cardiac disease. Patients were categorized based on left ventricular (LV) diastolic dysfunction using transmitral flow velocity as: restrictive or pseudonormal (PN) at , impaired relaxation (IR) at rest and during LPP (stable IR), and IR at rest and PN during LPP (unstable IR).

The researchers found that LPP increased LV end-diastolic pressure from 15.8 to 20.5 mm Hg in the unstable IR group and from 10.5 to 14.7 mm Hg in the stable IR group (both P < 0.001). Over an average of 548 days of follow-up, five patients had cardiac death, 37 had acute heart failure, four had an acute myocardial infarction, and seven had a stroke. In unstable IR the all-cause cardiac event rate was higher than in stable IR (P < 0.001), and was similar in the PN
group (P = 0.81). Similarly, in the unstable IR group event-free survival was significantly lower versus in stable IR (P = 0.003). Unstable IR was an independent predictor of all-cause cardiac events (hazard ratio: 8.0; P < 0.001).

"Pre-load stress echocardiography using LPP provides additional prognostic information in mild beyond that provided by conventional Doppler echocardiography at rest," the authors write.

Explore further: Liver insulin resistance correlates with cardiac risk

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Liver insulin resistance correlates with cardiac risk

April 16, 2012

(HealthDay) -- Liver insulin resistance (IR) may be a significant indicator of cardiovascular disease (CVD) risk among men, and correlates more closely with risk factors than whole-body insulin sensitivity, according to a ...

Activated carotid bodies key in metabolic disruption

April 17, 2013

(HealthDay)—Activation of carotid bodies (CB) by insulin may account for increased sympathoadrenal activity that results in insulin resistance (IR) and arterial hypertension, according to an experimental study published ...

Insulin resistance increases risk of colorectal adenomas

March 27, 2012

(HealthDay) -- Insulin resistance (IR) and central obesity, as measured by waist to hip ratio (WHR), are associated with a significantly increased risk of colorectal adenomas, especially in men, according to a study published ...

Study examines multivessel mortality rates

December 29, 2011

(Medical Xpress) -- A new study led by University at Albany School of Public Health Distinguished Professor Emeritus Edward L. Hannan finds a link between higher mortality rates and incomplete revascularization procedures ...

Recommended for you

Macrophages shown to be essential to a healthy heart rhythm

April 20, 2017

A Massachusetts General Hospital (MGH)-led research team has identified a surprising new role for macrophages, the white blood cells primarily known for removing pathogens, cellular debris and other unwanted materials. In ...

3-D-printed patch can help mend a 'broken' heart

April 14, 2017

A team of biomedical engineering researchers, led by the University of Minnesota, has created a revolutionary 3D-bioprinted patch that can help heal scarred heart tissue after a heart attack. The discovery is a major step ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.