Test helps predict which children with kidney disease will respond to standard therapy

July 24, 2014

A genetic screening test may help predict which patients with one of the most common childhood kidney diseases will respond to standard therapies. The test is described in a study appearing in an upcoming issue of the Journal of the American Society of Nephrology. Using this test could help guide clinicians as they counsel and treat patients.

Sporadic nephrotic syndrome is one of the most common kidney diseases in children, and it can have a genetic cause. Paola Romagnani, MD, PhD, Sabrina Giglio, MD, PhD (University of Florence and Meyer Children's Hospital, in Florence, Italy), and their colleagues designed an innovative diagnostic approach that allows for a fast analysis of all genes involved in the disease. Using this method, the team analyzed 46 different genes at the same time in 69 children with the disease, and they found that genetic mutations in the kidney's filtration barrier were frequently linked with a lack of response to immunosuppressive treatments in patients. The genetic test was even more predictive than a kidney biopsy for identifying children who would not benefit from .

"Thus, this type of genetic analysis can improve the clinical approach to children with nephrotic syndrome by promoting better for the risk of recurrence of the disease in the family, and a better management of treatment and clinical follow up," said Professor Romagnani.

The application of this new diagnostic approach also improved the speed of clinical diagnoses of the disease and reduced costs. "With a single test, we can help build a truly personalized therapy," said Professor Giglio.

Explore further: Autoimmune drug may help prevent kidney disease caused by diabetes

Related Stories

Autoimmune drug may help prevent kidney disease caused by diabetes

March 27, 2014
A drug currently used to treat autoimmune disease may also help prevent the kidney-damaging effects of diabetes, according to a study appearing in an upcoming issue of the Journal of the American Society of Nephrology (JASN). ...

Immune drug doesn't help kids with hard-to-treat kidney disorder

May 10, 2012
The drug rituximab, an antibody that targets the immune system and is often used to treat immune disorders such as lymphoma and arthritis, has recently emerged as a potential treatment for a childhood kidney disorder known ...

Gene mutations predict early, severe form of kidney disease

October 24, 2011
The most common kidney disease passed down through families, autosomal dominant polycystic kidney disease (ADPKD) affects one in 400 to 1,000 individuals and is characterized by cysts on the kidneys. The condition slowly ...

Extending steroid treatment does not benefit children with hard-to-treat kidney disease

December 20, 2012
Extending steroid treatment for the most common form of kidney disease in children provides no benefit for preventing relapses or side effects, according to a study appearing in an upcoming issue of the Journal of the American ...

Simple urine test detects common causes of kidney dysfunction after transplantation

March 6, 2014
A new noninvasive urine test can distinguish among different causes of acute kidney dysfunction after transplantation. The test, which is described in a study appearing in an upcoming issue of the Journal of the American ...

Recommended for you

Finish your antibiotics course? Maybe not, experts say

July 27, 2017
British disease experts on Thursday suggested doing away with the "incorrect" advice to always finish a course of antibiotics, saying the approach was fuelling the spread of drug resistance.

Co-infection with two common gut pathogens worsens malnutrition in mice

July 27, 2017
Two gut pathogens commonly found in malnourished children combine to worsen malnutrition and impair growth in laboratory mice, according to new research published in PLOS Pathogens.

Phase 3 trial confirms superiority of tocilizumab to steroids for giant cell arteritis

July 26, 2017
A phase 3 clinical trial has confirmed that regular treatment with tocilizumab, an inhibitor of interleukin-6, successfully reduced both symptoms of and the need for high-dose steroid treatment for giant cell arteritis, the ...

A large-scale 'germ trap' solution for hospitals

July 26, 2017
When an infectious airborne illness strikes, some hospitals use negative pressure rooms to isolate and treat patients. These rooms use ventilation controls to keep germ-filled air contained rather than letting it circulate ...

Researchers report new system to study chronic hepatitis B

July 25, 2017
Scientists from Princeton University's Department of Molecular Biology have successfully tested a cell-culture system that will allow researchers to perform laboratory-based studies of long-term hepatitis B virus (HBV) infections. ...

Male hepatitis B patients suffer worse liver ailments, regardless of lifestyle

July 25, 2017
Why men with hepatitis B remain more than twice as likely to develop severe liver disease than women remains a mystery, even after a study led by a recent Drexel University graduate took lifestyle choices and environments ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.