Neurocognitive deficits seen within days of T1DM diagnosis

July 8, 2014
Neurocognitive deficits seen within days of T1DM diagnosis

(HealthDay)—Deficits in neurocognitive functioning are evident within days of a type 1 diabetes diagnosis in children and are associated with glycemic control over one year postdiagnosis, according to a study published online June 26 in Diabetes Care.

David D. Schwartz, from the Baylor College of Medicine in Houston, and colleagues conducted neuropsychological testing among 147 children/adolescents (aged 5 to 18 years) during their inpatient hospitalization for new-onset . Comparisons were made to normative data, and they examined associations between neurocognitive performance at diagnosis and one year postdiagnosis.

The researchers found that on most cognitive measures, children with type 1 diabetes performed significantly below expectations (P values < 0.0001). Specifically, large decrements were seen in psychomotor speed, visuomotor integration, and phonemic fluency, compared to the normative mean. All tasks except digit span showed a high incidence of impairment (scores less than second percentile). When controlling for race/ethnicity, sex, and reading ability there was a significant association between dominant-hand psychomotor speed and (hemoglobin A1c ≥9.5 percent [80 mmol/mol]; P = 0.032) one year postdiagnosis. There was a 0.77 percent increase in mean hemoglobin A1c in association with impaired psychomotor speed.

"Psychomotor impairment may be an early marker for a broader neurobehavioral vulnerability that has implications for long-term diabetes management," the authors write.

Explore further: Routine blood glucose measurements can accurately estimate hemoglobin A1c in diabetes

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Bariatric surgery in T1DM teens doesn't aid glycemic control

September 27, 2013

(HealthDay)—Despite significant weight loss, improvements in cardiovascular risk factors, and quality of life, bariatric surgery does not necessarily lead to improved glycemic control in adolescents with type 1 diabetes ...

Study assesses glucose monitoring trends in tweens

April 12, 2012

(HealthDay) -- During the transition to adolescence, children with type 1 diabetes monitor their blood glucose less frequently, resulting in significant increases in HbA1c levels, according to research published online April ...

Chronic hyperglycemia tied to worse surgical outcomes

March 16, 2014

(HealthDay)—Chronic hyperglycemia (A1C >8 percent) is associated with poor surgical outcomes, as measured by an increased hospital length of stay (LOS), according to a study published in the March issue of Diabetes Care.

Gene profile correlates with glycemia in type 1 diabetes

March 16, 2012

(HealthDay) -- A gene expression profile in peripheral blood correlates with glycemic control in the first year for patients recently diagnosed with type 1 diabetes, according to a study published online March 8 in Diabetes.

Recommended for you

Post-biotics may help shield obese from diabetes

April 20, 2017

You've heard of pre-biotics and pro-biotics, but now you'll be hearing a lot more about post-biotics. Researchers at McMaster University have begun to identify how post-biotics, or the by-products of bacteria, lower blood ...

Diabetes continues its relentless rise

April 13, 2017

(HealthDay)—Two new studies on diabetes deliver good and bad news, but the overall message is that the blood sugar disease remains a formidable public health burden.

Researchers unravel how stevia controls blood sugar levels

April 11, 2017

What makes stevia taste so extremely sweet? And how does the sweetener keep our blood sugar level under control? Researchers at KU Leuven (University of Leuven, Belgium) have discovered that stevia stimulates a protein that ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.