Very low carbohydrate diet beneficial for obese with T2DM
(HealthDay)—For obese adults with type 2 diabetes mellitus (T2DM), a very low carbohydrate diet is associated with greater improvements in glycemic control and cardiovascular risk markers than an energy-matched high unrefined carbohydrate diet, according to a study published online July 28 in Diabetes Care.
Jeannie Tay, from the Commonwealth Scientific and Industrial Research Organization in Adelaide, Australia, and colleagues compared the effects of a very low carbohydrate, high unsaturated/low saturated fat diet (LC) with a high-unrefined carbohydrate, low fat diet (HC) on glycemic control and cardiovascular disease risk factors. Participants included 115 obese adults with T2DM who were randomized to 24 weeks of a hypocaloric LC diet or an energy-matched HC diet, combined with structured exercise.
Ninety-three participants completed the 24-week program, with similar completion rates (LC, 79 percent; HC, 82 percent). The researchers found that weight loss was similar between the groups (LC: −12.0 ± 6.3 kg versus HC: −11.5 ± 5.5 kg; P ≥ 0.50), and blood pressure, fasting blood glucose, and low-density lipoprotein cholesterol all decreased, with no diet effect (P ≥ 0.10). Greater reductions were seen in triglycerides, antiglycemic medication effects score, and glycemic variability indices with LC (P ≤ 0.03). In participants with baseline values of hemoglobin A1c >7.8 percent and high-density lipoprotein cholesterol <1.29 mmol/L, LC induced greater reductions in hemoglobin A1c (P = 0.002) and greater increases in high-density lipoprotein cholesterol (P = 0.007).
"This suggests an LC diet with low saturated fat may be an effective dietary approach for T2DM management if effects are sustained beyond 24 weeks," the authors write.
Full Text (subscription or payment may be required)
Copyright © 2014 HealthDay. All rights reserved.