FDA approves lung preservation machine (Update)

August 12, 2014

Federal health regulators have approved a novel device that can preserve donated lungs outside the body for possible transplantation into critically ill patients.

The Food and Drug Administration said Tuesday that the approval of the XVIVO Perfusion System could lead to more successful transplants of lungs for people with cystic fibrosis and other deadly respiratory diseases.

The device consists of a bubble-like chamber where the lungs are stored and connected to a series of pumps and filters that provide oxygen and a sterile cleansing solution. Lungs can be kept in the machine for four hours as doctors evaluate their suitability for transplant.

Only about one in five lungs currently donated meet the medical criteria for transplantation. By giving doctors more time to examine the organs, FDA officials say more lungs may ultimately be transplanted.

In 2012, 1,754 lung transplants were performed in the U.S. with 1,616 patients still on the national waiting list. Lung transplantation is often the only treatment for patients with end-stage lung diseases, including chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis.

The device is made by Englewood, Colorado-based XVIVO Perfusion Inc.

The FDA approved the new device based on two studies of patients who received non-ideal lungs preserved with the XVIVO Perfusion System or ideal lungs preserved with conventional cold storage techniques. The studies showed that patients from both groups had similar survival rates up to a year after undergoing transplant.

Explore further: Stem cell therapy may help recondition lungs previously rejected for transplant

Related Stories

Stem cell therapy may help recondition lungs previously rejected for transplant

July 10, 2014
Nearly 1,650 people in the U.S. are awaiting lung transplants. Unfortunately, both domestically and abroad, the demand for donor lungs far outpaces the supply. The limited availability of donor lungs can lead to long delays ...

Children win broader access to donor lungs

June 23, 2014
A national transplant board has permanently adopted a rule that gives children a better shot at donor lungs.

Many more lungs suitable for transplantation

June 30, 2011
Four patients now have new lungs thanks to a purpose-built machine used for the first time worldwide by Sahlgrenska University Hospital. Acquired for research at the Sahlgrenska Academy, University of Gothenburg, Sweden, ...

First US patient receives specially processed donor lungs at the University of Maryland

September 8, 2011
Surgeons at the University of Maryland Medical Center have transplanted the first lungs treated in the United States with an experimental repair process before transplantation. The procedure is part of a five-center national ...

World first: Lungs awaiting transplant preserved 11 hours outside body

October 16, 2013
The multidisciplinary transplant team at University Hospitals Leuven successfully preserved a set of donor lungs for over eleven hours with the help of a machine, the longest period ever reported. The lengthy preservation ...

First patient in US implanted with Hemolung before lifesaving double lung transplant

July 2, 2014
Suffering from cystic fibrosis and rejecting the transplanted lungs he had gotten just two years ago, Jon Sacker, 33, came to UPMC from his hometown in Moore, Oklahoma, as a last resort. But when his carbon dioxide levels ...

Recommended for you

Exploring the potential of human echolocation

June 25, 2017
People who are visually impaired will often use a cane to feel out their surroundings. With training and practice, people can learn to use the pitch, loudness and timbre of echoes from the cane or other sounds to navigate ...

Team eradicates hepatitis C in 10 patients following lifesaving transplants from infected donors

April 30, 2017
Ten patients at Penn Medicine have been cured of the Hepatitis C virus (HCV) following lifesaving kidney transplants from deceased donors who were infected with the disease. The findings point to new strategies for increasing ...

'bench to bedside to bench': Scientists call for closer basic-clinical collaborations

March 24, 2017
In the era of genome sequencing, it's time to update the old "bench-to-bedside" shorthand for how basic research discoveries inform clinical practice, researchers from The Jackson Laboratory (JAX), National Human Genome Research ...

The ethics of tracking athletes' biometric data

January 18, 2017
(Medical Xpress)—Whether it is a FitBit or a heart rate monitor, biometric technologies have become household devices. Professional sports leagues use some of the most technologically advanced biodata tracking systems to ...

Financial ties between researchers and drug industry linked to positive trial results

January 18, 2017
Financial ties between researchers and companies that make the drugs they are studying are independently associated with positive trial results, suggesting bias in the evidence base, concludes a study published by The BMJ ...

Best of Last Year – The top Medical Xpress articles of 2016

December 23, 2016
(Medical Xpress)—It was a big year for research involving overall health issues, starting with a team led by researchers at the UNC School of Medicine and the National Institutes of Health who unearthed more evidence that ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.