New test predicts individual's risk of a second kidney stone

August 7, 2014, American Society of Nephrology

A new tool that takes multiple factors into account can accurately predict how likely a patient who experienced a painful kidney stone will develop another one in the future. The tool, which is described in an upcoming issue of the Journal of the American Society of Nephrology (JASN), could help patients and their doctors determine whether preventive measures are needed.

Kidney stones are common and affect approximately 6% to 9% of the population. The greatest concern of who have experienced a kidney stone is whether this excruciating painful event will ever happen again. Certain dietary recommendations and medications can help prevent another kidney stone from forming, but these can be burdensome, expensive, or cause side effects. "If we knew which patients were at high risk for another symptomatic kidney stone, then we could better advise patients on whether to follow stone prevention diets or take medications," said Andrew Rule, MD (Mayo Clinic). "At the same time, patients who are at low risk of having another kidney stone may not need restrictive diets and medications."

Dr. Rule and his colleagues conducted a study to help them develop a prediction tool that could be used by patients and their to determine the risk of having a second symptomatic kidney stone after the first. The team reviewed the medical records of all adult first-time symptomatic stone formers residing in Olmsted County, Minnesota, from 1984 to 2003. Of the 2239 individuals identified, 707 experienced a recurrence through 2012.

From the information they gathered, the researchers developed the Recurrence of Kidney Stone (ROKS) nomogram that uses 11 questions about the patient to accurately calculate the probability of having another symptomatic kidney stone at 2, 5, or 10 years after the first stone. Characteristics that predict a higher risk include younger age, male gender, white race, family history of kidney stones, blood seen in the urine, stone made of uric acid (rather than calcium), obstructing stone in the kidney pelvis, any additional non-obstructing stone, and any past painful event attributed to a even though a stone was not seen.

In an accompanying editorial, Brian Eisner, MD (Massachusetts General Hospital and Harvard Medical School) and David Goldfarb, MD (York Harbor VA Healthcare System and NYU School of Medicine) noted that for the nomogram to demonstrate value, it now should be tested prospectively in additional populations of stone formers. "Whether additional variables can be added to increase the usefulness of this tool will be of interest in the ," they added.

Explore further: Guidelines issued for medical management of kidney stones

More information: The article, entitled "The ROKS Nomogram for Predicting a Second Symptomatic Stone Episode," will appear online at jasn.asnjournals.org/ on August 7, 2014.

The editorial, entitled, "A Nomogram for the Prediction of Kidney Stone Recurrence," will appear online at jasn.asnjournals.org/ on August, 7, 2014.

Related Stories

Guidelines issued for medical management of kidney stones

July 30, 2014
(HealthDay)—Guideline statements have been developed for the diagnosis, prevention, and follow-up of patients with kidney stones, and published in the August issue of The Journal of Urology.

Will a warmer climate mean more kidney stones?

July 10, 2014
(HealthDay)—Add another possible woe to the growing list of consequences of climate change: Kidney stones.

More effective kidney stone treatment, from the macroscopic to the nanoscale

April 17, 2014
Researchers in France have hit on a novel method to help kidney stone sufferers ensure they receive the correct and most effective treatment possible.

Macrophage-derived mediators may have potential as biomarkers for urinary stone risk

October 1, 2013
Arnhem, 30 September 2013- A balance between the activation of the inflammatory macrophages and suppression of the anti-inflammatory macrophages in the kidney may play a pivotal role in kidney stone formation. These macrophage-derived ...

History of kidney stones may indicate risk for stroke and heart attack

March 3, 2014
(Medical Xpress)—A new study from University of Alberta researchers suggests that patients, particularly women, with a history of kidney stones may be at a higher risk for stroke and heart attack.

Diet and physical activity may affect one's risk of developing kidney stones

December 12, 2013
Even small amounts of physical activity may decrease the risk of developing kidney stones, according to a study appearing in an upcoming issue of the Journal of the American Society of Nephrology (JASN). The study also found ...

Recommended for you

Deadly Rift Valley fever: New insight, and hope for the future

July 19, 2018
Health control measures alone could be ineffective in the long term fight against the deadly Rift Valley fever which affects both humans and animals, a new study in the journal PNAS reports.

Yeast species used in food industry causes disease in humans

July 19, 2018
A major cause of drug-resistant clinical yeast infections is the same species previously regarded as non-pathogenic and commonly used in the biotechnology and food industries. The study, published on July 19th in the open-access ...

New guidelines to diagnose, manage rare endocrine disorders

July 19, 2018
International guidelines have been published for the first time to help doctors around the globe diagnose and manage patients with a very rare set of endocrine diseases known as pseudohypoparathyroidism and its related disorders, ...

Overuse of antibiotics not what the doctor ordered

July 19, 2018
With increased use of antibiotics worldwide linked to growing antibiotic resistance, a world-first study co-authored by a QUT researcher has highlighted the growing impact of non-prescription supply of antibiotics in community ...

Alcohol-related cirrhosis deaths skyrocket in young adults

July 18, 2018
Deaths from cirrhosis rose in all but one state between 1999-2016, with increases seen most often among young adults, a new study shows.

Childhood abuse linked to greater risk of endometriosis, study finds

July 17, 2018
Endometriosis, a painful condition that affects one in 10 reproductive-age women in the U.S., has been linked to childhood physical and sexual abuse, according to findings published today in the journal Human Reproduction.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.