Women have greater atheroma regression with statins

Women have greater atheroma regression with statins

(HealthDay)—For patients with coronary atheroma, high-intensity statin treatment is associated with greater regression in women than men, according to a study published online Sept. 17 in JACC: Cardiovascular Imaging.

Rishi Puri, M.B.B.S., from the Cleveland Clinic in Ohio, and colleagues examined sex-related differences in coronary atheroma regression after high-intensity statin . Participants (765 and 274 women) were treated with rosuvastatin 40 mg or atorvastatin 80 mg for 24 months.

The researchers found that women were older and more likely to have hypertension; diabetes; and higher low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and C-reactive protein (CRP) levels than men. Compared with men, at follow-up had higher HDL-C (P < 0.001) and CRP (P < 0.001) but similar LDL-C (P = 0.46) levels. Women had lower baseline percent atheroma volume (PAV) and total atheroma volume (TAV) than men, but after treatment they demonstrated greater PAV regression (P = 0.03) and TAV regression (P = 0.11). Female sex was independently associated with PAV regression on multivariate analysis (P = 0.01), and there was a sex-treatment interaction (P = 0.036). Women achieved greater PAV and TAV regression than men among those with on-treatment LDL-C levels <70 mg/dl, while there was no difference by sex for those with LDL-C levels ≥70 mg/dl.

"Women with coronary disease demonstrate greater coronary atheroma regression than men when empirically prescribed guideline-driven potent statin therapy," the authors write.
Several authors disclosed financial ties to pharmaceutical and biotechnology companies, including AstraZeneca, which sponsored the study.


Explore further

Study finds no benefit over placebo in ASSURE trial

More information: Abstract
Full Text (subscription or payment may be required)

Copyright © 2014 HealthDay. All rights reserved.

Citation: Women have greater atheroma regression with statins (2014, October 8) retrieved 24 July 2019 from https://medicalxpress.com/news/2014-10-women-greater-atheroma-regression-statins.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
 shares

Feedback to editors

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more