Proton pump inhibitor use not linked to cardiac arrhythmia

Proton pump inhibitor use not linked to cardiac arrhythmia
In critically ill patients, proton pump inhibitor use is not associated with cardiac arrhythmia, according to a study published online Feb. 6 in the Journal of Clinical Pharmacology.

(HealthDay)—In critically ill patients, proton pump inhibitor (PPI) use is not associated with cardiac arrhythmia, according to a study published online Feb. 6 in the Journal of Clinical Pharmacology.

Kenneth P. Chen, M.D., from the Beth Israel Deaconess Medical Center in Boston, and colleagues examined whether PPI exposure correlated with admission electrocardiogram readings of a in a study involving more than 8,000 .

Within the cohort there were 25.4 percent PPI users and 6 percent taking a histamine 2 antagonist. Of the patients, 14.0 percent had a cardiac arrhythmia. The researchers found that the risk of arrhythmia in association with PPI use was 1.15 (95 percent confidence interval, 1.00 to 1.32; P = 0.04) in unadjusted analyses and 0.91 (95 percent confidence interval, 0.77 to 1.06; P = 0.22) in adjusted analyses. PPI use was not associated with increased risk of cardiac arrhythmia among diuretic users (2,476 patients).

"In summary, in a large cohort of critically ill patients, PPI exposure is not associated with an increased risk of cardiac arrhythmia," the authors write.


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Citation: Proton pump inhibitor use not linked to cardiac arrhythmia (2015, February 24) retrieved 16 April 2021 from https://medicalxpress.com/news/2015-02-proton-inhibitor-linked-cardiac-arrhythmia.html
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